CA2285350A1 - Traitement de la fibrose pulmonaire - Google Patents
Traitement de la fibrose pulmonaire Download PDFInfo
- Publication number
- CA2285350A1 CA2285350A1 CA002285350A CA2285350A CA2285350A1 CA 2285350 A1 CA2285350 A1 CA 2285350A1 CA 002285350 A CA002285350 A CA 002285350A CA 2285350 A CA2285350 A CA 2285350A CA 2285350 A1 CA2285350 A1 CA 2285350A1
- Authority
- CA
- Canada
- Prior art keywords
- halofuginone
- group
- pulmonary fibrosis
- compound
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000005069 pulmonary fibrosis Diseases 0.000 title claims abstract description 48
- 238000011282 treatment Methods 0.000 title claims description 26
- LVASCWIMLIKXLA-LSDHHAIUSA-N halofuginone Chemical compound O[C@@H]1CCCN[C@H]1CC(=O)CN1C(=O)C2=CC(Cl)=C(Br)C=C2N=C1 LVASCWIMLIKXLA-LSDHHAIUSA-N 0.000 claims abstract description 79
- 229950010152 halofuginone Drugs 0.000 claims abstract description 79
- 238000000034 method Methods 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 20
- 239000003937 drug carrier Substances 0.000 claims abstract description 12
- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- 239000000443 aerosol Substances 0.000 claims abstract description 7
- 150000001875 compounds Chemical class 0.000 claims description 31
- 125000003545 alkoxy group Chemical group 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 125000005605 benzo group Chemical group 0.000 claims description 8
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 150000002367 halogens Chemical class 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 150000002431 hydrogen Chemical class 0.000 claims description 7
- -1 hydroxy, acetoxy Chemical group 0.000 claims description 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 abstract description 10
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- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 description 1
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- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
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- AGSPXMVUFBBBMO-UHFFFAOYSA-O beta-ammoniopropionitrile Chemical compound [NH3+]CCC#N AGSPXMVUFBBBMO-UHFFFAOYSA-O 0.000 description 1
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- QCUFYOBGGZSFHY-UHFFFAOYSA-N depsidomycin Chemical compound O=C1C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(NC=O)C(C)CC)C(C)OC(=O)C2CCCNN2C(=O)C(CC(C)C)NC(=O)C2CCCNN21 QCUFYOBGGZSFHY-UHFFFAOYSA-N 0.000 description 1
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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- QVCMHGGNRFRMAD-XFGHUUIASA-N monocrotaline Chemical compound C1OC(=O)[C@](C)(O)[C@@](O)(C)[C@@H](C)C(=O)O[C@@H]2CCN3[C@@H]2C1=CC3 QVCMHGGNRFRMAD-XFGHUUIASA-N 0.000 description 1
- QVCMHGGNRFRMAD-UHFFFAOYSA-N monocrotaline Natural products C1OC(=O)C(C)(O)C(O)(C)C(C)C(=O)OC2CCN3C2C1=CC3 QVCMHGGNRFRMAD-UHFFFAOYSA-N 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
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- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention concerne une composition permettant de traiter la fibrose pulmonaire, ainsi qu'une méthode permettant d'utiliser et de fabriquer ladite composition. Cette dernière contient un dérivé de la quinazolinone, de préférence l'halofuginone. La voie d'administration préférée est l'inhalation, de préférence avec un support pharmaceutiquement acceptable se présentant sous forme d'aérosol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IL1997/000115 WO1998043642A1 (fr) | 1997-03-31 | 1997-03-31 | Traitement de la fibrose pulmonaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2285350A1 true CA2285350A1 (fr) | 1998-10-08 |
Family
ID=11061990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002285350A Abandoned CA2285350A1 (fr) | 1997-03-31 | 1997-03-31 | Traitement de la fibrose pulmonaire |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0991411A4 (fr) |
| JP (1) | JP2001518062A (fr) |
| AU (1) | AU737094B2 (fr) |
| CA (1) | CA2285350A1 (fr) |
| WO (1) | WO1998043642A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4808997A (en) | 1996-09-30 | 1998-04-24 | Brigham And Women's Hospital | Methods and compounds for treatment of abnormal uterine bleeding |
| IL148246A0 (en) * | 1999-09-09 | 2002-09-12 | Hadasit Med Res Service | Promotion of wound healing |
| ES2447834T3 (es) | 2007-01-21 | 2014-03-13 | Agricultural Research Organization | Composición y método para tratar o prevenir la fibrosis del músculo esquelético |
| AU2013270622B2 (en) * | 2007-01-21 | 2016-05-19 | Agricultural Research Organization | Composition and method for treating or preventing skeletal muscle fibrosis |
| US10155742B2 (en) | 2012-01-13 | 2018-12-18 | President And Fellows Of Harvard College | Halofuginol derivatives and their use in cosmetic and pharmaceutical compositions |
| EP3801525A4 (fr) | 2018-06-08 | 2022-03-23 | The General Hospital Corporation | Inhibiteurs de la prolyl-arnt-synthétase |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2113229C (fr) * | 1994-01-11 | 1999-04-20 | Mark Pines | Compositions anti-fibreuses contenant de la quinazolinone et methodes d'utilisation correspondantes |
| US6028075A (en) * | 1997-02-11 | 2000-02-22 | Pines; Mark | Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies |
-
1997
- 1997-03-31 AU AU20420/97A patent/AU737094B2/en not_active Ceased
- 1997-03-31 WO PCT/IL1997/000115 patent/WO1998043642A1/fr not_active Ceased
- 1997-03-31 EP EP97908480A patent/EP0991411A4/fr not_active Ceased
- 1997-03-31 JP JP52550097A patent/JP2001518062A/ja not_active Ceased
- 1997-03-31 CA CA002285350A patent/CA2285350A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001518062A (ja) | 2001-10-09 |
| EP0991411A1 (fr) | 2000-04-12 |
| AU2042097A (en) | 1998-10-22 |
| EP0991411A4 (fr) | 2000-05-31 |
| AU737094B2 (en) | 2001-08-09 |
| WO1998043642A1 (fr) | 1998-10-08 |
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