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CA2279492A1 - Tolerance immunologique aux epitopes du hiv - Google Patents

Tolerance immunologique aux epitopes du hiv Download PDF

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Publication number
CA2279492A1
CA2279492A1 CA002279492A CA2279492A CA2279492A1 CA 2279492 A1 CA2279492 A1 CA 2279492A1 CA 002279492 A CA002279492 A CA 002279492A CA 2279492 A CA2279492 A CA 2279492A CA 2279492 A1 CA2279492 A1 CA 2279492A1
Authority
CA
Canada
Prior art keywords
seq
cells
epitopes
cell
hiv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002279492A
Other languages
English (en)
Inventor
David Scott
Elias Zambidis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American National Red Cross
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2279492A1 publication Critical patent/CA2279492A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2
    • G01N2333/162—HIV-1, HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, DC4-Binding site

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des protéines d'immunoglobuline de fusion (fIg) comprenant un ou plusieurs épitopes hétérologues associés à des maladies pour lesquelles la réponse immunitaire est négative, lesdites protéines étant utiles pour induire une tolérance auxdits épitopes. Les épitopes gp120 du HIV-1 associés à l'intérieur d'un cadre à une chaîne lourde (H) d'Ig sont des produits de synthèse utiles pour induire une tolérance au HIV, spécifique aux épitopes. Le traitement d'un sujet avec ce type de produit de synthèse, ou bien avec des cellules lymphoïdes ou hématopoïétiques exprimant ou sécrétant ces molécules fIg, induit une tolérance immunologique spécifique aux épitopes considérés. En empêchant la production d'anticorps dirigés contre les épitopes gp120 déterminés, cette tolérance peut prévenir ou inhiber l'apoptose de "voisinage" sur les cellules T hôtes non infectées ayant effectué une liaison, à leurs molécules CD4 de surface, avec la protéine gp 120 du HIV et subissant ensuite une réticulation sous l'effet d'anticorps parasites anti-gp120. Cela donne pour les cellules T en question une amorce à l'apoptose, en présence des antigènes qui les activent. On utilise de préférence les épitopes gp120 correspondant à des épitopes de lymphocites B non neutralisants ou certains épitopes de lymphocytes T auxiliaires pour élaborer les molécules fIg. Outre les chaînes H de fIg et les molécules d'Ig complètes, l'invention concerne l'ADN codant les chaînes H en question et les cellules transformées par ce type d'ADN.
CA002279492A 1997-02-13 1998-02-13 Tolerance immunologique aux epitopes du hiv Abandoned CA2279492A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4058197P 1997-02-13 1997-02-13
US60/040,581 1997-02-13
PCT/US1998/002766 WO1998036087A1 (fr) 1997-02-13 1998-02-13 Tolerance immunologique aux epitopes du hiv

Publications (1)

Publication Number Publication Date
CA2279492A1 true CA2279492A1 (fr) 1998-08-20

Family

ID=21911760

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002279492A Abandoned CA2279492A1 (fr) 1997-02-13 1998-02-13 Tolerance immunologique aux epitopes du hiv

Country Status (3)

Country Link
EP (1) EP0973933A1 (fr)
CA (1) CA2279492A1 (fr)
WO (1) WO1998036087A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115262B1 (en) 1999-03-16 2006-10-03 The United States Of America As Represented By The Department Of Health And Human Services Chimeric protein for prevention and treatment of HIV infection
GB9926084D0 (en) * 1999-11-03 2000-01-12 King S College London Recombinant fusion molecules
EP2258712A3 (fr) 2002-03-15 2011-05-04 Multicell Immunotherapeutics, Inc. Compositions et procédés permettant d'initier ou d'ameliorer les réponses des cellules T limitées par le complexe majeur d 'histocompatibilité de classe I ou II et un anticorps au moyen de motifs d'ARN non codants immunomodulateurs
WO2005097822A1 (fr) * 2004-04-09 2005-10-20 University Of Manitoba Identification de la sequence precise d'acides amines de l'epitope identifie par l'anticorps monoclonal igg1b12 puissant de neutralisation anti-vih 1 humain
WO2007022477A2 (fr) * 2005-08-17 2007-02-22 Multicell Immunotherapeutics, Inc. Méthodes et compositions pour produire et contrôler le profil effecteur de lymphocytes t par chargement et activation simultanés de sous-ensembles sélectionnés de cellules présentatrices d'antigène
EP1878744A1 (fr) 2006-07-13 2008-01-16 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Epitope-tag pour des récepteurs de cellules T exprimés en surface, leurs utilisations et méthode de selection de cellules hôtes les exprimant
WO2015077789A2 (fr) 2013-11-25 2015-05-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Récepteurs d'antigènes chimériques pour lutter contre une infection par le vih
US11046959B2 (en) 2015-03-30 2021-06-29 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas Compositions comprising TALENs and methods of treating HIV
JP6924151B2 (ja) 2015-05-29 2021-08-25 ユニヴァーシティー オブ ユタ リサーチ ファウンデーション 免疫寛容及び非免疫寛容エラスチン様組換えペプチドならびに使用方法
WO2016207782A1 (fr) * 2015-06-22 2016-12-29 STRELNIKOV, Evgeny Oligopeptides synthétiques immunogènes pour un vaccin contre le vih
CA3076099A1 (fr) 2017-09-22 2019-03-28 Kite Pharma, Inc. Lieurs pour des recepteurs d'antigene chimerique
EP3691693A4 (fr) 2017-10-06 2021-08-25 University Of Utah Research Foundation Protéine de fusion pour une thérapie ciblée de maladie auto-immune
CN113621032A (zh) * 2019-11-08 2021-11-09 贵州医科大学 一种具有seq id no.2序列的多肽以及具有强adcc效应的抗体和应用

Also Published As

Publication number Publication date
WO1998036087A1 (fr) 1998-08-20
EP0973933A1 (fr) 2000-01-26

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Legal Events

Date Code Title Description
FZDE Discontinued