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CA2277544A1 - Identification d'inhibiteurs de la proteine tyrosine-kinase 2 - Google Patents

Identification d'inhibiteurs de la proteine tyrosine-kinase 2 Download PDF

Info

Publication number
CA2277544A1
CA2277544A1 CA002277544A CA2277544A CA2277544A1 CA 2277544 A1 CA2277544 A1 CA 2277544A1 CA 002277544 A CA002277544 A CA 002277544A CA 2277544 A CA2277544 A CA 2277544A CA 2277544 A1 CA2277544 A1 CA 2277544A1
Authority
CA
Canada
Prior art keywords
pyk2
compound
ability
activity
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002277544A
Other languages
English (en)
Inventor
Le T. Duong
Gideon A. Rodan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2277544A1 publication Critical patent/CA2277544A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des dosages de composés qui se lient à la protéine tyrosine-kinase 2 ou qui modulent son activité. Ces ligands sont utilisés pour le traitement de l'ostéoporose et/ou de l'inflammation.
CA002277544A 1997-02-11 1998-02-09 Identification d'inhibiteurs de la proteine tyrosine-kinase 2 Abandoned CA2277544A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3756097P 1997-02-11 1997-02-11
US60/037,560 1997-02-11
PCT/US1998/002797 WO1998035056A1 (fr) 1997-02-11 1998-02-09 Identification d'inhibiteurs de la proteine tyrosine-kinase 2

Publications (1)

Publication Number Publication Date
CA2277544A1 true CA2277544A1 (fr) 1998-08-13

Family

ID=21895000

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002277544A Abandoned CA2277544A1 (fr) 1997-02-11 1998-02-09 Identification d'inhibiteurs de la proteine tyrosine-kinase 2

Country Status (5)

Country Link
EP (1) EP0968304A1 (fr)
JP (1) JP2001512309A (fr)
AU (1) AU6163398A (fr)
CA (1) CA2277544A1 (fr)
WO (1) WO1998035056A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6165598A (en) 1997-02-18 1998-09-08 Lxr Biotechnology Inc. Bak promotor expression system
US6958148B1 (en) 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
US6919076B1 (en) 1998-01-20 2005-07-19 Pericor Science, Inc. Conjugates of agents and transglutaminase substrate linking molecules
US6861442B1 (en) 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
EP1630559A3 (fr) * 1998-12-30 2006-06-07 Sugen, Inc. PYK2 (RAFTK) et inflammation
EP1141722A1 (fr) * 1998-12-31 2001-10-10 Sugen, Inc. Pyk2 (raftk) et inflammation
AU5951201A (en) * 2000-05-04 2001-11-12 Univ Yale High density protein arrays for screening of protein activity
US20030040461A1 (en) * 2000-10-23 2003-02-27 Mcatee C. Patrick Modulators of Bruton'sTyrosine Kinase and Bruton's Tyrosine Kinase intermediates and methods for their identification and use in the treatment and prevention of osteoporosis and related diseases states
CA2452390A1 (fr) * 2001-06-29 2003-01-09 Ab Science Utilisation d'inhibiteurs de la tyrosine kinase dans le traitement de la perte osseuse
US7678805B2 (en) 2001-06-29 2010-03-16 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (IBD)
JP2004537537A (ja) 2001-06-29 2004-12-16 アブ サイエンス 炎症性疾患を治療するためのチロシンキナーゼ阻害剤の使用法
WO2003002106A2 (fr) 2001-06-29 2003-01-09 Ab Science Utilisation d'inhibiteurs de tyrosine kinase dans le traitement de maladies allergiques
JP2005500041A (ja) 2001-06-29 2005-01-06 アブ サイエンス 強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤
JP2007524374A (ja) * 2003-02-28 2007-08-30 プレキシコン，インコーポレーテッド Ｐｙｋ２結晶構造および使用
JP2008503561A (ja) * 2004-06-21 2008-02-07 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 骨芽細胞機能を刺激するためのｐｙｋ２阻害薬

Also Published As

Publication number Publication date
EP0968304A1 (fr) 2000-01-05
AU6163398A (en) 1998-08-26
WO1998035056A1 (fr) 1998-08-13
JP2001512309A (ja) 2001-08-21

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Legal Events

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FZDE Dead