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CA2274661A1 - Hydrogel ameliore pour la creation de tissu - Google Patents

Hydrogel ameliore pour la creation de tissu Download PDF

Info

Publication number
CA2274661A1
CA2274661A1 CA002274661A CA2274661A CA2274661A1 CA 2274661 A1 CA2274661 A1 CA 2274661A1 CA 002274661 A CA002274661 A CA 002274661A CA 2274661 A CA2274661 A CA 2274661A CA 2274661 A1 CA2274661 A1 CA 2274661A1
Authority
CA
Canada
Prior art keywords
hydrogel
composition
alginate
soluble salt
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002274661A
Other languages
English (en)
Inventor
Kermit M. Borland
Tao Zhou
Gordon P. Nelson
Daniel R. Omstead
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curis Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2274661A1 publication Critical patent/CA2274661A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention porte sur des compostions destinées à être implantées chez un animal et comprenant un polymère biodégradable, biocompatible, qui forme un hydrogel lors de la réticulation. Selon un mode préféré, le polymère est réticulé par des ions multivalents, plus souhaitablement, un sel soluble d'un ion multivalent et un sel modérément soluble d'un ion multivalent, ces composants étant combinés pour obtenir un mélange formant un hydrogel injectable, partiellement durci, la consistance du mélange étant appropriée pour implanter le mélange d'hydrogel partiellement durci chez un animal. Cet hydrogel implanté, partiellement durci, forme in situ un hydrogel totalement durci. De préférence, le mélange contient également un agent séquestrant biocompatible qui rivalise avec le polymère biocompatible dans la liaison de l'ion de réticulation multivalent. Cette composition peut ou peut ne pas contenir de cellules vivantes. L'invention porte également sur des procédés d'implantation de la composition chez un animal, celle-ci pouvant être un implant contenant des cellules vivantes.
CA002274661A 1996-12-10 1997-12-10 Hydrogel ameliore pour la creation de tissu Abandoned CA2274661A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US76273396A 1996-12-10 1996-12-10
US08/762,733 1996-12-10
US5108497P 1997-06-27 1997-06-27
US60/051,084 1997-06-27
US5955897P 1997-09-19 1997-09-19
US60/059,558 1997-09-19
PCT/US1997/022859 WO1998025653A2 (fr) 1996-12-10 1997-12-10 Hydrogel ameliore pour la creation de tissu

Publications (1)

Publication Number Publication Date
CA2274661A1 true CA2274661A1 (fr) 1998-06-18

Family

ID=27367902

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002274661A Abandoned CA2274661A1 (fr) 1996-12-10 1997-12-10 Hydrogel ameliore pour la creation de tissu

Country Status (5)

Country Link
EP (1) EP0944403A2 (fr)
JP (1) JP4002299B2 (fr)
AU (1) AU742316B2 (fr)
CA (1) CA2274661A1 (fr)
WO (1) WO1998025653A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051164A1 (fr) 1998-04-03 1999-10-14 Reprogenesis, Inc. Dispositif de reconstruction des tissus mous et son procede d'utilisation
WO2000029552A1 (fr) * 1998-11-16 2000-05-25 Osiris Therapeutics, Inc. Systeme de couche d'alginate pour la differenciation chondrogene de cellules souches mesenchymateuses de l'homme
US6761887B1 (en) * 1998-11-16 2004-07-13 Osiris Therapeutics, Inc. Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells
IT1311576B1 (it) 1999-10-25 2002-03-13 Ghimas Spa Dispositivo medico invasivo, in particolare per la rigenerazionetissutale guidata.
US20040106896A1 (en) * 2002-11-29 2004-06-03 The Regents Of The University Of California System and method for forming a non-ablative cardiac conduction block
CA2615607A1 (fr) * 2005-07-21 2007-02-08 Fmc Biopolymer As Dispositifs medicaux revetus d'un revetement biocompatible a dissolution rapide
MX2009008760A (es) 2007-02-21 2009-08-27 Mochida Pharm Co Ltd Composicion para el tratamiento de enfermedades del cartilago.
JP5161482B2 (ja) * 2007-05-09 2013-03-13 オリンパス株式会社 生体組織補填材の製造方法
IL187707A0 (en) * 2007-11-27 2008-11-03 Univ Ben Gurion Alginate scaffold in hepatectomy
US8367637B2 (en) 2008-08-19 2013-02-05 Mochida Pharmaceutical Co., Ltd. Composition for treating arthritic disorder
US9308070B2 (en) 2008-12-15 2016-04-12 Allergan, Inc. Pliable silk medical device
US8420077B2 (en) 2009-04-20 2013-04-16 Allergan, Inc. Silk fibroin hydrogels and uses thereof
WO2017044896A1 (fr) * 2015-09-09 2017-03-16 Dsm Ip Assets B.V. Compositions d'adhésis et de produits de scellement biomédicaux et leurs procédés d'utilisation
EP3973953A1 (fr) * 2016-04-01 2022-03-30 Boston Scientific Scimed Inc. Compositions injectables et leurs procédés de préparation et d'utilisation
CN117731600A (zh) * 2018-02-09 2024-03-22 波士顿科学国际有限公司 凝胶组合物及其制备和用途
CN112969479A (zh) * 2018-11-06 2021-06-15 国立癌症中心 海藻酸基注射型凝胶体系
EP4021519A1 (fr) * 2019-08-27 2022-07-06 Crannmed Limited Particules à base d'alginate en tant qu'agent embolique temporaire
WO2023282247A1 (fr) * 2021-07-05 2023-01-12 国立大学法人滋賀医科大学 Agent de formation de tissu

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352883A (en) 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
JPS63177791A (ja) 1987-01-16 1988-07-21 Kibun Kk 固定化酵素又は固定化微生物の製造法
DE4103876C2 (de) * 1990-02-09 1994-07-07 Asahi Optical Co Ltd Verfahren zur Fixierung einer körnigen Knochen-Prothese und Kit zur Herstellung einer körnigen Knochen-Prothesezusammensetzung zur Verwendung in dem Fixierungsverfahren
NO171069C (no) * 1990-05-29 1993-01-20 Protan Biopolymer As Kovalent tverrbundne, sterkt svellende alkalimetall- og ammonium-alginatgeler, samt fremgangsmaate for fremstilling derav
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5658329A (en) * 1995-02-14 1997-08-19 Mentor Corporation Filling material for soft tissue implant prostheses and implants made therewith
US6129761A (en) * 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
WO1997017038A1 (fr) * 1995-11-09 1997-05-15 University Of Massachusetts Regeneration de surfaces tissulaires a l'aide de compositions hydrogel-cellules

Also Published As

Publication number Publication date
WO1998025653A3 (fr) 1998-10-15
EP0944403A2 (fr) 1999-09-29
JP4002299B2 (ja) 2007-10-31
JP2001505809A (ja) 2001-05-08
AU5698698A (en) 1998-07-03
AU742316B2 (en) 2001-12-20
WO1998025653A2 (fr) 1998-06-18

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Legal Events

Date Code Title Description
FZDE Discontinued