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CA2271135A1 - Nucleosides - Google Patents

Nucleosides Download PDF

Info

Publication number
CA2271135A1
CA2271135A1 CA002271135A CA2271135A CA2271135A1 CA 2271135 A1 CA2271135 A1 CA 2271135A1 CA 002271135 A CA002271135 A CA 002271135A CA 2271135 A CA2271135 A CA 2271135A CA 2271135 A1 CA2271135 A1 CA 2271135A1
Authority
CA
Canada
Prior art keywords
guanine
mmole
valyl
butyl
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002271135A
Other languages
English (en)
Inventor
Nils-Gunnar Johansson
Xiao-Xiong Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medivir AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9604154A external-priority patent/SE9604154D0/xx
Priority claimed from SE9604165A external-priority patent/SE9604165D0/xx
Priority claimed from SE9702957A external-priority patent/SE9702957D0/xx
Application filed by Individual filed Critical Individual
Publication of CA2271135A1 publication Critical patent/CA2271135A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Esters mélangés de nucléosides antiviraux, tels que des composés représentés par la formule (I) dans laquelle B représente une base de nucléotide naturelle ou non, X représente O ou CH¿2?, Y et Z représente chacun H ou constituent ensemble une liaison ou Y représente méthylène ou -CH(OH)- et Z représente une liaison avec ces dernières; n est 0 ou 1; un de R¿1? et de R¿2? représente le résidu acyle d'un acide amino aliphatique et l'autre représente alkyle -C(=O)C¿5?-C¿21?, et leurs sels acceptables sur le plan pharmaceutique, possédant des propriétés pharmacocinétiques et d'autres propriétés avantageuses.
CA002271135A 1996-11-12 1997-11-12 Nucleosides Abandoned CA2271135A1 (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
SE9604165-2 1996-11-12
SE9604154A SE9604154D0 (sv) 1996-11-12 1996-11-12 Anticancer compounds
SE9604165A SE9604165D0 (sv) 1996-11-12 1996-11-12 Antivirals
SE9604154-6 1996-11-12
US79821897A 1997-02-10 1997-02-10
US91292797A 1997-08-15 1997-08-15
SE9702957A SE9702957D0 (sv) 1997-08-15 1997-08-15 Antivirals
US08/798,218 1997-08-15
US08/912,927 1997-08-15
SE9702957-3 1997-08-15
PCT/SE1997/001903 WO1998021223A1 (fr) 1996-11-12 1997-11-12 Nucleosides

Publications (1)

Publication Number Publication Date
CA2271135A1 true CA2271135A1 (fr) 1998-05-22

Family

ID=27532793

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002271135A Abandoned CA2271135A1 (fr) 1996-11-12 1997-11-12 Nucleosides

Country Status (6)

Country Link
EP (1) EP0942916A2 (fr)
JP (1) JP2001503767A (fr)
KR (1) KR20000053226A (fr)
AU (1) AU735438B2 (fr)
CA (1) CA2271135A1 (fr)
WO (1) WO1998021223A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
EP1123935B1 (fr) * 1997-08-15 2005-04-13 Medivir Ab Dérivés de guanosine 3'-fluorés pour le traitement ou la prophylaxie des infections HBV ou retrovirales
WO1999051613A1 (fr) * 1998-04-03 1999-10-14 Medivir Ab Promedicaments de produits pharmaceutiques contenant du phosphore
ES2229820T3 (es) * 1998-10-16 2005-04-16 Schering Corporation Terapia de combinacion ribavirina-interferon alfa para erradicar el hcv-rna detectable en pacientes con infeccion por hepatitis c cronica.
US6403564B1 (en) 1998-10-16 2002-06-11 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
US6277830B1 (en) * 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
EP1282632A1 (fr) 2000-04-20 2003-02-12 Schering Corporation Traitement combine de ribavirine-interferon alfa pour eliminer l'arn-vhc decelable chez un patient souffrant d'infections chroniques par l'hepatite c
MX242714B (es) * 2001-11-14 2006-12-15 Teva Pharma Sintesis y purificacion de valaciclovir.
PT1523489E (pt) * 2002-06-28 2014-06-24 Centre Nat Rech Scient Profármacos de nucleósido modificado em 2' e 3' para tratamento de infecções por flaviridae
KR20050055630A (ko) * 2002-06-28 2005-06-13 이데닉스 (케이만) 리미티드 플라비비리다에 감염 치료를 위한 1'-, 2'- 및 3'-변형된뉴클레오시드 유도체
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
DE102017219046A1 (de) 2017-10-25 2019-04-25 BSH Hausgeräte GmbH Haushaltsgerät zur Pflege von Wäschestücken mit einer Unwuchtausgleichsvorrichtung mit verformbarer Bremseinheit und Verfahren zum Betreiben eines derartigen Haushaltsgeräts

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2789989A (en) * 1987-10-28 1989-05-23 Pro-Neuron, Inc. Acylated uridine and cytidine and uses thereof
CA2005815C (fr) * 1988-12-19 1999-08-03 Wellcome Foundation Limited (The) Derives antiviraux de nucleoside acyclique
GB9515279D0 (en) * 1995-07-25 1995-09-20 Norsk Hydro As Improved therapeutic agents
DE4311801A1 (de) * 1993-04-09 1994-10-13 Hoechst Ag Neue Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives

Also Published As

Publication number Publication date
AU735438B2 (en) 2001-07-05
AU5075998A (en) 1998-06-03
KR20000053226A (ko) 2000-08-25
WO1998021223A1 (fr) 1998-05-22
JP2001503767A (ja) 2001-03-21
EP0942916A2 (fr) 1999-09-22

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Legal Events

Date Code Title Description
FZDE Dead