CA2268007A1 - Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire - Google Patents
Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire Download PDFInfo
- Publication number
- CA2268007A1 CA2268007A1 CA002268007A CA2268007A CA2268007A1 CA 2268007 A1 CA2268007 A1 CA 2268007A1 CA 002268007 A CA002268007 A CA 002268007A CA 2268007 A CA2268007 A CA 2268007A CA 2268007 A1 CA2268007 A1 CA 2268007A1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne une nouvelle protéine de l'inhibiteur cérébro-associé de l'activateur du plasminogène de type tissulaire (BAIT), laquelle est un membre de la superfamille des serpines, qui s'exprime généralement dans le tissu du cerveau. L'invention concerne notamment des molécules d'acides nucléiques isolées codant la protéine humaine BAIT. On décrit également des polypeptides BAIT en tant que vecteurs et cellules hôtes, ainsi que des procédés de recombinaison aux fins de production de ceux-ci. L'invention concerne encore des procédés de criblage destinés à l'identification des agonistes et antagonistes de l'activité de BAIT, des procédés de diagnostic destinés à détecter des troubles associés au système nerveux, de même que des procédés thérapeutiques destinés au traitement de troubles associés au système nerveux.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1996/016484 WO1998016643A1 (fr) | 1996-10-11 | 1996-10-11 | Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2268007A1 true CA2268007A1 (fr) | 1998-04-23 |
Family
ID=22255955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002268007A Abandoned CA2268007A1 (fr) | 1996-10-11 | 1996-10-11 | Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0934410A1 (fr) |
| JP (1) | JP2002501365A (fr) |
| AU (1) | AU7431796A (fr) |
| CA (1) | CA2268007A1 (fr) |
| WO (1) | WO1998016643A1 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235529B2 (en) | 1996-10-11 | 2007-06-26 | Human Genome Sciences, Inc. | Brain-associated inhibitor of tissue-type plasminogen activator |
| WO1999041381A1 (fr) * | 1998-02-13 | 1999-08-19 | Peter Sonderegger | Neuroserpine |
| WO2000053793A1 (fr) | 1999-03-10 | 2000-09-14 | Human Genome Sciences, Inc. | Inhibiteur cerebro-associe de l'activateur du plasminogene de type tissulaire |
| WO2000065349A2 (fr) * | 1999-04-28 | 2000-11-02 | Cardiogenics Inc. | Procede de determination d'inhibiteur d'un activateur de plasminogene |
| GB0217033D0 (en) | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
| GB0217434D0 (en) | 2002-07-27 | 2002-09-04 | Royal Vetinary College | Biological material |
| GB0315323D0 (en) | 2003-07-01 | 2003-08-06 | Royal Veterinary College | Vaccine composition |
| US9023366B2 (en) | 2003-07-01 | 2015-05-05 | The Royal Veterinary College | Vaccine composition for vaccinating dogs against canine infectious respiratory disease (CIRD) |
| CN102712695B (zh) | 2009-12-18 | 2015-01-21 | 堪瑟拉公司 | 能够诱导细胞死亡的ror1生物抑制剂 |
| GB201020995D0 (en) | 2010-12-10 | 2011-01-26 | Bioinvent Int Ab | Biological materials and uses thereof |
| GB201219678D0 (en) | 2012-11-01 | 2012-12-12 | Benf Ab | Ketone body inhibitors and uses thereof |
| EP3587439A3 (fr) | 2013-03-01 | 2020-03-11 | Boehringer Ingelheim Animal Health USA Inc. | Quantification améliorée de compositions de vaccin |
| GB201320679D0 (en) | 2013-11-22 | 2014-01-08 | Univ Nottingham | Polypeptides,polynucleotides and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5700924A (en) * | 1995-06-07 | 1997-12-23 | Incyte Pharmaceuticals, Inc. | Serpin derived from human hypothalamus |
-
1996
- 1996-10-11 EP EP96936500A patent/EP0934410A1/fr not_active Ceased
- 1996-10-11 JP JP51829398A patent/JP2002501365A/ja not_active Withdrawn
- 1996-10-11 AU AU74317/96A patent/AU7431796A/en not_active Abandoned
- 1996-10-11 WO PCT/US1996/016484 patent/WO1998016643A1/fr not_active Ceased
- 1996-10-11 CA CA002268007A patent/CA2268007A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU7431796A (en) | 1998-05-11 |
| JP2002501365A (ja) | 2002-01-15 |
| WO1998016643A1 (fr) | 1998-04-23 |
| EP0934410A1 (fr) | 1999-08-11 |
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| Date | Code | Title | Description |
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