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CA2265512A1 - Protease sans detergent de l'hepatite c - Google Patents

Protease sans detergent de l'hepatite c Download PDF

Info

Publication number
CA2265512A1
CA2265512A1 CA002265512A CA2265512A CA2265512A1 CA 2265512 A1 CA2265512 A1 CA 2265512A1 CA 002265512 A CA002265512 A CA 002265512A CA 2265512 A CA2265512 A CA 2265512A CA 2265512 A1 CA2265512 A1 CA 2265512A1
Authority
CA
Canada
Prior art keywords
protease
hcv
detergent
gly
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002265512A
Other languages
English (en)
Inventor
Vinod V. Sardana
Jeffrey T. Blue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625802.5A external-priority patent/GB9625802D0/en
Application filed by Individual filed Critical Individual
Publication of CA2265512A1 publication Critical patent/CA2265512A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Detergent Compositions (AREA)

Abstract

On purifie la protéase du virus de l'hépatite C (HCV) sans détergent et on peut l'utiliser en tant qu'outil de criblage afin de rechercher des agents antiviraux anti HCV, ainsi qu'en tant qu'outil servant à diagnostiquer des maladies provenant d'une infection par HCV.
CA002265512A 1996-09-27 1997-09-23 Protease sans detergent de l'hepatite c Abandoned CA2265512A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2727496P 1996-09-27 1996-09-27
US60/027,274 1996-09-27
GB9625802.5 1996-12-12
GBGB9625802.5A GB9625802D0 (en) 1996-12-12 1996-12-12 Detergent-free hepatitis C protease
PCT/US1997/017029 WO1998013482A1 (fr) 1996-09-27 1997-09-23 Protease sans detergent de l'hepatite c

Publications (1)

Publication Number Publication Date
CA2265512A1 true CA2265512A1 (fr) 1998-04-02

Family

ID=26310605

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002265512A Abandoned CA2265512A1 (fr) 1996-09-27 1997-09-23 Protease sans detergent de l'hepatite c

Country Status (5)

Country Link
EP (1) EP0931141A2 (fr)
JP (1) JP2000506395A (fr)
AU (1) AU4590297A (fr)
CA (1) CA2265512A1 (fr)
WO (1) WO1998013482A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5829757A (en) * 1996-10-11 1998-11-03 Mearthane Products Corporation Variable traction wheel for in-line roller skate
US20030134292A1 (en) * 2001-10-30 2003-07-17 Farchaus Joseph W. Thermostable DNA polymerases and methods of making same
DE602004023924D1 (en) * 2003-04-18 2009-12-17 Enanta Pharm Inc Ease-hemmer

Also Published As

Publication number Publication date
EP0931141A2 (fr) 1999-07-28
WO1998013482A1 (fr) 1998-04-02
JP2000506395A (ja) 2000-05-30
AU4590297A (en) 1998-04-17

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued