CA2255493C - Photochemical agent for use as a glue - Google Patents
Photochemical agent for use as a glue Download PDFInfo
- Publication number
- CA2255493C CA2255493C CA 2255493 CA2255493A CA2255493C CA 2255493 C CA2255493 C CA 2255493C CA 2255493 CA2255493 CA 2255493 CA 2255493 A CA2255493 A CA 2255493A CA 2255493 C CA2255493 C CA 2255493C
- Authority
- CA
- Canada
- Prior art keywords
- tissue
- activated
- glue
- electromagnetic radiation
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003292 glue Substances 0.000 title claims abstract description 9
- 239000003795 chemical substances by application Substances 0.000 title abstract description 20
- 230000005670 electromagnetic radiation Effects 0.000 claims abstract description 17
- 229920002994 synthetic fiber Polymers 0.000 claims abstract description 6
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims description 17
- 231100000252 nontoxic Toxicity 0.000 abstract description 3
- 230000003000 nontoxic effect Effects 0.000 abstract description 3
- 210000001519 tissue Anatomy 0.000 description 15
- 230000035515 penetration Effects 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 229920004934 Dacron® Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000003364 biologic glue Substances 0.000 description 1
- 238000007675 cardiac surgery Methods 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 230000023753 dehiscence Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000010102 embolization Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229910000679 solder Inorganic materials 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000007631 vascular surgery Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Dental Preparations (AREA)
Abstract
A physiologically suitable, non-toxic photochemical agent for use as a glue to bind a synthetic material to tissue and tissue to tissue is disclosed wherein the agent is activated by exposure to electromagnetic radiation.
Description
PHOTOCHEMICAL AGENT FOR USE AS A GLUE
FIELD OF THE INVENTION:
This invention relates to the use of a physiologically suitable, non=toxic photochemical agent as a glue to bind a synthetic material to living tissue and tissue to tissue, wherein said agent is .activated by electromagnetic radiation.
BACKGROUND OF THE INVENTION:
Means of attachment of a synthetic material such as a patch or the like to living tissue or of tissue to tissue have included use of sutures, staples and the like as well as various glues, many of which are heat activated. By way of example, collagen has been used as a heat activated glue, the thermal bonding occurring with the denaturation of the collagen when:it is exposed to heat. The applicability of thermal bonding is however limited.
It is not applicable to the vascular system due to the weak strength of the solder and the risk of dehiscence post-surgery.
SUMMARY OF THE INVENTION:
In one broad embodiment, the invention relates to a physiologically suitable, non-toxic photochemical agent for use as a glue to bind a synthetic material to living tissue and tissue to tissue, wherein the agent is activated by exposure to electromagnetic radiation. In a preferred embodiment, the agent is activated by exposure to electromagnetic radiation in a range of about 647 to 700 nm.
.30 _ ~ _ DESCRIPTION OF THE PREFERRED EMBODIIVIBNT:
During surgery and particularly during minimally invasive pediatric cardiac surgery, there is a need for the use of a biological glue which is activated by exposure to electromagnetic radiation. The present invention is based on the unexpected discovery that photochemical agents which are activated by exposure to electromagnetic radiation can be used to bind living tissue to synthetic material as well as tissue to tissue.
There are many photochemical agents available. The agent chosen depends on the application to which it is put. The agent selected has of course to be physiologically suitable and non-toxic. If the photochemical agent is activated by electromagnetic radiation in'the blue range (424 to 491 nm), tissue penetration of a depth of 1 mm occurs.
The advantages involved with the use of radiation in this range is that the photochemical agent can be activated using a flexible light wand. Using light in the green range (491 nm to 575 nm), one can effect tissue penetration at a depth of 2 to 3 mm. The use of a photochemical agent activated by electromagnetic radiation in the blue and green light range would have applications in fields other than vascular surgery. In the vascular system, a greater depth of penetration is necessary. Tissue depth is critical within the vascular system/intracardiac repairs and an agent which is activated by electromagnetic radiation in the red range (647 to 700 nm) should be used in such a system. The depth of penetration is then approximately 5 to 7 mm.
An example of a suitable agent is naphthalin, C10Hg, having a molecular weight of 128.17.
Naphthalin is activated by electromagnetic radiation in the range of 647 to 700 nm. -By way of example, during the course of surgery, a synthetic Dacron patch is adhered to the heart muscle to close a hole in the heart without the need for sutures and/or staples. by impregnating the said patch with a solution of naphtalin. The patch is then placed in position and held while being subjected to electromagnetic radiation in the 647 to 700 nm range by means of a photon emitting light source which is brought into proximity.
* Trade-mark - 2 -The use of photochemical agents which are activated by electromagnetic radiation in the range of 640 to 700 nm has been found to be ideal for valve implantation and closure of holes within the heart, either congenital or acquired. Such procedures can be performed in a minimally invasive manner and with less ischemic time to the myocardium. The photochemical welding can be performed both accurately and without the.spillage of any agents, a potential source of embolization, as could be the case with a regular glue, and quickly thus reducing the inflammatory reaction of cardiopulmonary bypass.
Those skilled in the art will appreciate the described embodiment, while preferred, can be modified to a greater or lesser degree. I therefore wish to embody within the scope of the patent which may be granted hereon all such embodiments as reasonably and properly come within the scope of my contribution to the art.
_3 _
FIELD OF THE INVENTION:
This invention relates to the use of a physiologically suitable, non=toxic photochemical agent as a glue to bind a synthetic material to living tissue and tissue to tissue, wherein said agent is .activated by electromagnetic radiation.
BACKGROUND OF THE INVENTION:
Means of attachment of a synthetic material such as a patch or the like to living tissue or of tissue to tissue have included use of sutures, staples and the like as well as various glues, many of which are heat activated. By way of example, collagen has been used as a heat activated glue, the thermal bonding occurring with the denaturation of the collagen when:it is exposed to heat. The applicability of thermal bonding is however limited.
It is not applicable to the vascular system due to the weak strength of the solder and the risk of dehiscence post-surgery.
SUMMARY OF THE INVENTION:
In one broad embodiment, the invention relates to a physiologically suitable, non-toxic photochemical agent for use as a glue to bind a synthetic material to living tissue and tissue to tissue, wherein the agent is activated by exposure to electromagnetic radiation. In a preferred embodiment, the agent is activated by exposure to electromagnetic radiation in a range of about 647 to 700 nm.
.30 _ ~ _ DESCRIPTION OF THE PREFERRED EMBODIIVIBNT:
During surgery and particularly during minimally invasive pediatric cardiac surgery, there is a need for the use of a biological glue which is activated by exposure to electromagnetic radiation. The present invention is based on the unexpected discovery that photochemical agents which are activated by exposure to electromagnetic radiation can be used to bind living tissue to synthetic material as well as tissue to tissue.
There are many photochemical agents available. The agent chosen depends on the application to which it is put. The agent selected has of course to be physiologically suitable and non-toxic. If the photochemical agent is activated by electromagnetic radiation in'the blue range (424 to 491 nm), tissue penetration of a depth of 1 mm occurs.
The advantages involved with the use of radiation in this range is that the photochemical agent can be activated using a flexible light wand. Using light in the green range (491 nm to 575 nm), one can effect tissue penetration at a depth of 2 to 3 mm. The use of a photochemical agent activated by electromagnetic radiation in the blue and green light range would have applications in fields other than vascular surgery. In the vascular system, a greater depth of penetration is necessary. Tissue depth is critical within the vascular system/intracardiac repairs and an agent which is activated by electromagnetic radiation in the red range (647 to 700 nm) should be used in such a system. The depth of penetration is then approximately 5 to 7 mm.
An example of a suitable agent is naphthalin, C10Hg, having a molecular weight of 128.17.
Naphthalin is activated by electromagnetic radiation in the range of 647 to 700 nm. -By way of example, during the course of surgery, a synthetic Dacron patch is adhered to the heart muscle to close a hole in the heart without the need for sutures and/or staples. by impregnating the said patch with a solution of naphtalin. The patch is then placed in position and held while being subjected to electromagnetic radiation in the 647 to 700 nm range by means of a photon emitting light source which is brought into proximity.
* Trade-mark - 2 -The use of photochemical agents which are activated by electromagnetic radiation in the range of 640 to 700 nm has been found to be ideal for valve implantation and closure of holes within the heart, either congenital or acquired. Such procedures can be performed in a minimally invasive manner and with less ischemic time to the myocardium. The photochemical welding can be performed both accurately and without the.spillage of any agents, a potential source of embolization, as could be the case with a regular glue, and quickly thus reducing the inflammatory reaction of cardiopulmonary bypass.
Those skilled in the art will appreciate the described embodiment, while preferred, can be modified to a greater or lesser degree. I therefore wish to embody within the scope of the patent which may be granted hereon all such embodiments as reasonably and properly come within the scope of my contribution to the art.
_3 _
Claims (5)
1. Use of naphthalene as a glue to bind a synthetic material to a tissue wherein the naphthalene is activated by exposure to electromagnetic radiation.
2. Use of naphthalene as a glue to bind a first tissue to a second tissue wherein the naphthalene is activated by exposure to electromagnetic radiation.
3. The use of claim 1 or claim 2 wherein the naphthalene is activated by exposure to electromagnetic radiation in a range of 424 to 491 nm.
4. The use of claim 1 or claim 2 wherein the naphthalene is activated by exposure to electromagnetic radiation in a range of 491 to 575 nm.
5. The use of claim I or claim 2 wherein the naphthalene is activated by exposure to electromagnetic radiation in a range of 647 to 700 nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2255493 CA2255493C (en) | 1998-12-09 | 1998-12-09 | Photochemical agent for use as a glue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2255493 CA2255493C (en) | 1998-12-09 | 1998-12-09 | Photochemical agent for use as a glue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2255493A1 CA2255493A1 (en) | 2000-06-09 |
| CA2255493C true CA2255493C (en) | 2008-11-18 |
Family
ID=29425794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2255493 Expired - Fee Related CA2255493C (en) | 1998-12-09 | 1998-12-09 | Photochemical agent for use as a glue |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2255493C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7073510B2 (en) | 2000-02-11 | 2006-07-11 | The General Hospital Corporation | Photochemical tissue bonding |
| SG10201806020VA (en) | 2014-01-14 | 2018-08-30 | Univ Nanyang Tech | Electroactive bioadhesive compositions |
-
1998
- 1998-12-09 CA CA 2255493 patent/CA2255493C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2255493A1 (en) | 2000-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20151209 |