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CA2253941A1 - Derives de la thiophenetryptamine et de la furanetryptamine - Google Patents

Derives de la thiophenetryptamine et de la furanetryptamine Download PDF

Info

Publication number
CA2253941A1
CA2253941A1 CA002253941A CA2253941A CA2253941A1 CA 2253941 A1 CA2253941 A1 CA 2253941A1 CA 002253941 A CA002253941 A CA 002253941A CA 2253941 A CA2253941 A CA 2253941A CA 2253941 A1 CA2253941 A1 CA 2253941A1
Authority
CA
Canada
Prior art keywords
indole
group
thienyl
substituted
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002253941A
Other languages
English (en)
Inventor
Sumanas Rakhit
Abdelmalik Slassi
Qingchang Meng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allelix Biopharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/648,842 external-priority patent/US5770742A/en
Application filed by Individual filed Critical Individual
Publication of CA2253941A1 publication Critical patent/CA2253941A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dérivés de substitution en 5 de tryptamine, sélectifs vis-à-vis des récepteurs D1 de la 5-HT et, par conséquent, aptes à soulager les symptômes de la migraine. Les analogues sont représentés par la formule chimique générale (I), dans laquelle T représente un groupe thiophène avec substitution facultative, de formule (a), lié au noyau d'indole via sa position 2 ou 3, ou un groupe furane avec substitution facultative, de formule (b), lié au noyau d'indole via sa position 2 ou 3; X représente H, un alkyle C1-C4, un hydroxyalkyle C1-C4 ou un halogène en position 4 ou 5 du noyau; Y représente une liaison directe ou un groupe alkylène C1-C3 avec substitution facultative par un hydroxyle; enfin Z représente un groupe amino, amino avec substitution mono- ou di-N-alkyle inférieur, amino avec substitution par un alkyle inférieur, ou un groupe N-hétérocyclique choisi parmi la pyrrolidine, la pyrroline, l'azétidine et la pipéridine; le groupe N-hétérocyclique est avec substitution facultative par au moins un substituant choisi indépendamment parmi un alkyle inférieur, un alcoxy(inférieur)alkyle(inférieur) et un hydroxyalkyle(inférieur).
CA002253941A 1996-05-16 1997-05-16 Derives de la thiophenetryptamine et de la furanetryptamine Abandoned CA2253941A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/648,842 US5770742A (en) 1996-05-16 1996-05-16 Thiophene-tryptamine derivatives
US08/648,842 1996-05-16
US83577897A 1997-04-07 1997-04-07
US08/835,778 1997-04-07
PCT/CA1997/000333 WO1997043281A1 (fr) 1996-05-16 1997-05-16 Derives de la thiophenetryptamine et de la furanetryptamine

Publications (1)

Publication Number Publication Date
CA2253941A1 true CA2253941A1 (fr) 1997-11-20

Family

ID=27095474

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002253941A Abandoned CA2253941A1 (fr) 1996-05-16 1997-05-16 Derives de la thiophenetryptamine et de la furanetryptamine

Country Status (3)

Country Link
AU (1) AU2759597A (fr)
CA (1) CA2253941A1 (fr)
WO (1) WO1997043281A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9651534B1 (en) 2015-12-02 2017-05-16 Sani-Hawk Optical Solutions LLC Optical chemical test systems and methods

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
US6562809B1 (en) * 1998-09-18 2003-05-13 Nps Allelix Corp. 3-bicycloindole compounds
WO2004056769A2 (fr) 2002-12-20 2004-07-08 Ciba Specialty Chemicals Holding Inc. Synthèse d'amines et intermédiaires pour cette synthèse
IL301066A (en) * 2020-09-04 2023-05-01 Gilgamesh Pharmaceuticals Inc Azetidinyl tryptamines and methods for the treatment of psychiatric disorders
WO2025104490A1 (fr) * 2023-11-14 2025-05-22 Mindset Pharma Inc. Dérivés d'indole utilisés en tant qu'agents sérotoninergiques utiles pour le traitement de troubles associés

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
GB9313913D0 (en) * 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
JPH07271066A (ja) * 1994-03-29 1995-10-20 Mitsubishi Paper Mills Ltd 電子写真感光体
US5504101A (en) * 1994-05-06 1996-04-02 Allelix Biopharmaceuticals, Inc. 5-HT-1D receptor ligands

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9651534B1 (en) 2015-12-02 2017-05-16 Sani-Hawk Optical Solutions LLC Optical chemical test systems and methods

Also Published As

Publication number Publication date
WO1997043281A1 (fr) 1997-11-20
AU2759597A (en) 1997-12-05

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Legal Events

Date Code Title Description
FZDE Discontinued