CA2245079A1 - Imagerie de ventilation au moyen d'un generateur d'aerosol a fines particules - Google Patents
Imagerie de ventilation au moyen d'un generateur d'aerosol a fines particules Download PDFInfo
- Publication number
- CA2245079A1 CA2245079A1 CA 2245079 CA2245079A CA2245079A1 CA 2245079 A1 CA2245079 A1 CA 2245079A1 CA 2245079 CA2245079 CA 2245079 CA 2245079 A CA2245079 A CA 2245079A CA 2245079 A1 CA2245079 A1 CA 2245079A1
- Authority
- CA
- Canada
- Prior art keywords
- formulation
- radioactive
- patient
- container
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000443 aerosol Substances 0.000 title claims abstract description 37
- 238000009423 ventilation Methods 0.000 title abstract description 28
- 238000003384 imaging method Methods 0.000 title description 3
- 239000010419 fine particle Substances 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims abstract description 142
- 238000009472 formulation Methods 0.000 claims abstract description 138
- 230000002285 radioactive effect Effects 0.000 claims abstract description 111
- 239000012528 membrane Substances 0.000 claims abstract description 104
- 239000012857 radioactive material Substances 0.000 claims abstract description 102
- 210000004072 lung Anatomy 0.000 claims abstract description 84
- 238000012384 transportation and delivery Methods 0.000 claims abstract description 67
- 239000011148 porous material Substances 0.000 claims abstract description 49
- 238000000034 method Methods 0.000 claims abstract description 45
- 239000002245 particle Substances 0.000 claims description 137
- 239000000463 material Substances 0.000 claims description 59
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 42
- 230000005855 radiation Effects 0.000 claims description 28
- 230000007246 mechanism Effects 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 9
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims description 6
- 229960003330 pentetic acid Drugs 0.000 claims description 6
- 239000012669 liquid formulation Substances 0.000 claims description 2
- 239000012876 carrier material Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 abstract description 3
- 238000000576 coating method Methods 0.000 abstract description 3
- 230000003434 inspiratory effect Effects 0.000 description 64
- 208000010378 Pulmonary Embolism Diseases 0.000 description 28
- 238000010438 heat treatment Methods 0.000 description 17
- 238000009826 distribution Methods 0.000 description 16
- 238000005259 measurement Methods 0.000 description 16
- 230000010412 perfusion Effects 0.000 description 16
- 238000001704 evaporation Methods 0.000 description 15
- 230000008020 evaporation Effects 0.000 description 14
- 239000007789 gas Substances 0.000 description 14
- 239000000243 solution Substances 0.000 description 14
- 230000002685 pulmonary effect Effects 0.000 description 13
- 238000012544 monitoring process Methods 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- 230000008901 benefit Effects 0.000 description 10
- 230000004087 circulation Effects 0.000 description 10
- 241000894007 species Species 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 208000005189 Embolism Diseases 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 230000004199 lung function Effects 0.000 description 7
- 230000002829 reductive effect Effects 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
- 150000001450 anions Chemical group 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 238000010304 firing Methods 0.000 description 6
- 230000009325 pulmonary function Effects 0.000 description 6
- 239000012298 atmosphere Substances 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 239000013078 crystal Substances 0.000 description 5
- CEJLBZWIKQJOAT-UHFFFAOYSA-N dichloroisocyanuric acid Chemical compound ClN1C(=O)NC(=O)N(Cl)C1=O CEJLBZWIKQJOAT-UHFFFAOYSA-N 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000000969 carrier Substances 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000000241 respiratory effect Effects 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 241000490229 Eucephalus Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000005856 abnormality Effects 0.000 description 3
- 208000024716 acute asthma Diseases 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 230000009969 flowable effect Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000003595 mist Substances 0.000 description 3
- 238000012806 monitoring device Methods 0.000 description 3
- 238000009206 nuclear medicine Methods 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 239000004417 polycarbonate Substances 0.000 description 3
- 229920000515 polycarbonate Polymers 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 208000023504 respiratory system disease Diseases 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- UVKNREAAHQRBKA-IEOVAKBOSA-I 2-[bis[2-[bis(carboxylatomethyl)amino]ethyl]amino]acetate;technetium-99(4+) Chemical compound [99Tc+4].[O-]C(=O)CN(CC([O-])=O)CCN(CC(=O)[O-])CCN(CC([O-])=O)CC([O-])=O UVKNREAAHQRBKA-IEOVAKBOSA-I 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 2
- 241000905957 Channa melasoma Species 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000008321 arterial blood flow Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 230000001010 compromised effect Effects 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 229910052750 molybdenum Inorganic materials 0.000 description 2
- 239000011733 molybdenum Substances 0.000 description 2
- 238000012633 nuclear imaging Methods 0.000 description 2
- 230000000414 obstructive effect Effects 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000004088 pulmonary circulation Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000013125 spirometry Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 206010006482 Bronchospasm Diseases 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 101000927799 Homo sapiens Rho guanine nucleotide exchange factor 6 Proteins 0.000 description 1
- 229910019445 Mg(ClO4) Inorganic materials 0.000 description 1
- 229910000978 Pb alloy Inorganic materials 0.000 description 1
- 102100033202 Rho guanine nucleotide exchange factor 6 Human genes 0.000 description 1
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 239000012300 argon atmosphere Substances 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000007885 bronchoconstriction Effects 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000012255 calcium oxide Nutrition 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 230000002542 deteriorative effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000010102 embolization Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000009795 fibrotic process Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 230000003094 perturbing effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000002588 pulmonary angiography Methods 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 239000012217 radiopharmaceutical Substances 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 210000005241 right ventricle Anatomy 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1206—Administration of radioactive gases, aerosols or breath tests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
- A61B5/0813—Measurement of pulmonary parameters by tracers, e.g. radioactive tracers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
- A61B6/4258—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Dispersion Chemistry (AREA)
- Atmospheric Sciences (AREA)
- Physiology (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Une méthode de diagnostic sur un patient, qui consiste à envoyer à un patient une dose sous forme d'aérosol d'une formulation radioactive et à réaliser une image de ventilation de la substance radioactive déposée dans le poumon. L'invention concerne également des dispositifs et une méthodologie pour la création d'aérosols, qui permettent d'envoyer de manière efficace et répétée des radioaérosols dans les poumons d'un patient. Le dispositif est équipé d'un récipient (1) contenant une formulation radioactive (5). L'actionnement du dispositif envoie la formulation radioactive (5) à travers une membrane poreuse (3) du récipient, membrane présentant des pores d'un diamètre de l'ordre d'environ 0,25 micron à 6,0 microns. Le récipient comporte un écran anti-radioactivité (84) se présentant sous la forme d'une couche de plomb et/ou d'un enveloppe au plomb. La membrane poreuse (3) est alignée avec une surface du canal (6) par lequel le patient inhale l'air.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59708996A | 1996-02-05 | 1996-02-05 | |
| US08/597,089 | 1996-02-05 | ||
| US08/789,551 | 1997-01-27 | ||
| US08/789,551 US5829436A (en) | 1996-02-05 | 1997-01-27 | Ventilation imaging using a fine particle aerosol generator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2245079A1 true CA2245079A1 (fr) | 1997-08-07 |
Family
ID=27082724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2245079 Abandoned CA2245079A1 (fr) | 1996-02-05 | 1997-02-04 | Imagerie de ventilation au moyen d'un generateur d'aerosol a fines particules |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0955885A1 (fr) |
| CA (1) | CA2245079A1 (fr) |
| WO (1) | WO1997027804A1 (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111634915A (zh) * | 2020-06-12 | 2020-09-08 | 将乐三晶新材料有限公司 | 熔融金属硅雾化制粉工艺 |
| WO2024079330A1 (fr) * | 2022-10-14 | 2024-04-18 | AlmediS Altmann GmbH | Dispositif et procédé de génération d'un aérosol sec radiomarqué |
| CN118452562A (zh) * | 2024-07-12 | 2024-08-09 | 深圳市酷斯达科技有限公司 | 一种电子雾化器输出模块监测方法和系统 |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
| US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| US7498019B2 (en) | 2001-05-24 | 2009-03-03 | Alexza Pharmaceuticals, Inc. | Delivery of compounds for the treatment of headache through an inhalation route |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| WO2002094242A1 (fr) | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Administration de rizatriptan ou de zolmitriptan par voie d'inhalation |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| CA2447519C (fr) | 2001-05-24 | 2008-09-16 | Alexza Molecular Delivery Corporation | Administration par voie pulmonaire d'alprazolam, d'estazolam, de midazolam ou de triazolam |
| CA2446904A1 (fr) | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Administration d'esters medicamenteux par inhalation |
| WO2003041693A1 (fr) | 2001-11-09 | 2003-05-22 | Alexza Molecular Delivery Corporation | Administration de diazepam a travers une voie pulmonaire |
| CA2460343A1 (fr) | 2001-11-21 | 2003-07-17 | Alexza Molecular Delivery Corporation | Delivrance de cafeine par voie inhalee |
| US7550133B2 (en) | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| JP2007516404A (ja) | 2003-05-21 | 2007-06-21 | アレックザ ファーマシューティカルズ， インコーポレイテッド | 光学点火されたかまたは電気点火された内蔵式加熱ユニットおよびそれを使用する薬剤供給ユニット |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| EP2246086A3 (fr) | 2004-08-12 | 2012-11-21 | Alexza Pharmaceuticals, Inc. | Dispositif d'administration de médicament en aérosol comprenant une unité de chauffage allumée par percussion |
| EP2121088B1 (fr) | 2007-03-09 | 2016-07-13 | Alexza Pharmaceuticals, Inc. | Unité chauffante à utiliser dans un dispositif d'administration de médicament |
| EP2077132A1 (fr) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispositif distributeur, dispositif de stockage et procédé pour la distribution d'une formulation |
| WO2010112358A2 (fr) | 2009-03-31 | 2010-10-07 | Boehringer Ingelheim International Gmbh | Procédé de revêtement d'une surface d'un composant |
| EP3508239B1 (fr) | 2009-05-18 | 2020-12-23 | Boehringer Ingelheim International GmbH | Adaptateur, dispositif d'inhalation et pulvérisateur |
| US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2011064163A1 (fr) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nébuliseur |
| AU2010323220B2 (en) | 2009-11-25 | 2015-04-23 | Boehringer Ingelheim International Gmbh | Nebulizer |
| US9943654B2 (en) | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
| US20120048963A1 (en) | 2010-08-26 | 2012-03-01 | Alexza Pharmaceuticals, Inc. | Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter |
| EP2694220B1 (fr) | 2011-04-01 | 2020-05-06 | Boehringer Ingelheim International GmbH | Appareil médical pourvu d'un récipient |
| US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2013152894A1 (fr) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Pulvérisateur comprenant des moyens de détrompage |
| ES2836977T3 (es) | 2013-08-09 | 2021-06-28 | Boehringer Ingelheim Int | Nebulizador |
| JP6643231B2 (ja) | 2013-08-09 | 2020-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
| EP3139979B1 (fr) | 2014-05-07 | 2023-07-05 | Boehringer Ingelheim International GmbH | Unité, nébuliseur et procédé |
| US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
| SG11201608891RA (en) | 2014-05-07 | 2016-11-29 | Boehringer Ingelheim Int | Nebulizer, indicator device and container |
| HUE064899T2 (hu) | 2015-03-11 | 2024-04-28 | Alexza Pharmaceuticals Inc | Antisztatikus anyagok használata a légcsatornában a termális aeroszol kondenzációs folyamat létrehozására |
| KR102852740B1 (ko) | 2018-02-02 | 2025-08-29 | 알렉스자 파마스티칼즈, 인크. | 전기적 응축 에어로졸 디바이스 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4510929A (en) * | 1982-04-30 | 1985-04-16 | Bordoni Maurice E | Disposable radioactive aerosol inhalation apparatus |
| ATE84427T1 (de) * | 1984-10-04 | 1993-01-15 | I J & L A Tetley Manufacturing | Geraet zur erzeugung eines gasgemisches fuer diagnostische zwecke. |
| CA1315897C (fr) * | 1987-08-07 | 1993-04-06 | John Waser | Procede de production d'aerosols pour la mesure scintigraphique de la ventilation pulmonaire, et dispositif correspondant |
| FR2673142A1 (fr) | 1991-02-21 | 1992-08-28 | Ribal Annick | Dispositif de soudure autonome, portatif pour poches plastiques. |
| US5404871A (en) | 1991-03-05 | 1995-04-11 | Aradigm | Delivery of aerosol medications for inspiration |
| US5450336A (en) | 1991-03-05 | 1995-09-12 | Aradigm Corporation | Method for correcting the drift offset of a transducer |
| US5394866A (en) | 1991-03-05 | 1995-03-07 | Aradigm Corporation | Automatic aerosol medication delivery system and methods |
| US5522385A (en) * | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
-
1997
- 1997-02-04 EP EP97906502A patent/EP0955885A1/fr not_active Withdrawn
- 1997-02-04 WO PCT/US1997/001888 patent/WO1997027804A1/fr not_active Ceased
- 1997-02-04 CA CA 2245079 patent/CA2245079A1/fr not_active Abandoned
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111634915A (zh) * | 2020-06-12 | 2020-09-08 | 将乐三晶新材料有限公司 | 熔融金属硅雾化制粉工艺 |
| WO2024079330A1 (fr) * | 2022-10-14 | 2024-04-18 | AlmediS Altmann GmbH | Dispositif et procédé de génération d'un aérosol sec radiomarqué |
| CN118452562A (zh) * | 2024-07-12 | 2024-08-09 | 深圳市酷斯达科技有限公司 | 一种电子雾化器输出模块监测方法和系统 |
| CN118452562B (zh) * | 2024-07-12 | 2024-11-12 | 深圳市酷斯达科技有限公司 | 一种电子雾化器输出模块监测方法和系统 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997027804A1 (fr) | 1997-08-07 |
| EP0955885A1 (fr) | 1999-11-17 |
| EP0955885A4 (fr) | 1999-12-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5792057A (en) | Ventilation imaging using a fine particle aerosol generator | |
| CA2245079A1 (fr) | Imagerie de ventilation au moyen d'un generateur d'aerosol a fines particules | |
| US5829436A (en) | Ventilation imaging using a fine particle aerosol generator | |
| US5522385A (en) | Dynamic particle size control for aerosolized drug delivery | |
| JP3748890B2 (ja) | 呼吸器薬物のエアロゾル化噴霧に使用するための使い捨て容器、使い捨てパッケージ、薬物輸送装置、及びエアロゾルを生成する方法 | |
| JP3708964B2 (ja) | インシュリンのエアロゾル化製剤の製造 | |
| US5934272A (en) | Device and method of creating aerosolized mist of respiratory drug | |
| US6647987B2 (en) | Insulin delivery enhanced by coached breathing | |
| AU741913B2 (en) | Device for administering insulin in controlled dosages by controlling total inhaled volume | |
| AU708269B2 (en) | Device for aerosolized delivery of peptide drugs | |
| EP1310268B1 (fr) | Dispositif pour diffusion intra-pulmonaire de medicaments selon des valeurs de débit/volume inspiratoires therapeutiquement significatives | |
| US7448375B2 (en) | Method of treating diabetes mellitus in a patient | |
| EP1366778A2 (fr) | Systèmes d'apport intrapulmonaire de formulations aqueuses en aérosol | |
| US20080264416A1 (en) | Method of Treating Diabetes Mellitus in a Patient | |
| WO1998022170A1 (fr) | Dispositif et procede permettant de diriger un embrun d'aerosol vers une zone specifique de l'appareil respiratoire | |
| CA2301122A1 (fr) | Mecanisme d'extrusion d'aerosols | |
| JP2002234831A (ja) | 機能生物学的物質の粗いスプレー供給 | |
| Newman et al. | Therapeutic aerosol deposition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |