CA2129043C - Use of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine for the treatment of pain and oedema - Google Patents
Use of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine for the treatment of pain and oedema Download PDFInfo
- Publication number
- CA2129043C CA2129043C CA002129043A CA2129043A CA2129043C CA 2129043 C CA2129043 C CA 2129043C CA 002129043 A CA002129043 A CA 002129043A CA 2129043 A CA2129043 A CA 2129043A CA 2129043 C CA2129043 C CA 2129043C
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- Prior art keywords
- pain
- treatment
- oedema
- compound
- triazine
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- 238000007911 parenteral administration Methods 0.000 description 1
- 230000007331 pathological accumulation Effects 0.000 description 1
- 230000008289 pathophysiological mechanism Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 208000030062 persistent idiopathic facial pain Diseases 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- FROBCXTULYFHEJ-OAHLLOKOSA-N propaquizafop Chemical compound C1=CC(O[C@H](C)C(=O)OCCON=C(C)C)=CC=C1OC1=CN=C(C=C(Cl)C=C2)C2=N1 FROBCXTULYFHEJ-OAHLLOKOSA-N 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9203483.4 | 1992-02-19 | ||
| GB929203483A GB9203483D0 (en) | 1992-02-19 | 1992-02-19 | Anti-inflammatory compounds |
| PCT/GB1993/000341 WO1993016700A1 (en) | 1992-02-19 | 1993-02-18 | Use of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine for the treatment of pain and ×dema |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2129043A1 CA2129043A1 (en) | 1993-09-02 |
| CA2129043C true CA2129043C (en) | 2004-01-27 |
Family
ID=10710643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002129043A Expired - Fee Related CA2129043C (en) | 1992-02-19 | 1993-02-18 | Use of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine for the treatment of pain and oedema |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5712277A (es) |
| EP (1) | EP0626851B1 (es) |
| KR (1) | KR950700067A (es) |
| AT (1) | ATE204476T1 (es) |
| AU (1) | AU684711B2 (es) |
| CA (1) | CA2129043C (es) |
| CY (1) | CY2299B1 (es) |
| DE (1) | DE69330638T2 (es) |
| DK (1) | DK0626851T3 (es) |
| ES (1) | ES2162813T3 (es) |
| GB (2) | GB9203483D0 (es) |
| GR (1) | GR3036958T3 (es) |
| IL (1) | IL104775A (es) |
| MX (1) | MX9300927A (es) |
| NZ (1) | NZ249197A (es) |
| PT (1) | PT626851E (es) |
| TW (1) | TW226331B (es) |
| WO (1) | WO1993016700A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9424766D0 (en) * | 1994-12-07 | 1995-02-08 | Wellcome Found | Pharmaceutical composition |
| JPH11501007A (ja) * | 1994-12-30 | 1999-01-26 | ザ、ウェルカム、ファンデーション、リミテッド | ラモトリジンの製造法 |
| GB9625795D0 (en) * | 1996-12-12 | 1997-01-29 | Smithkline Beecham Plc | Novel treatment |
| GB9726987D0 (en) | 1997-12-22 | 1998-02-18 | Glaxo Group Ltd | Compounds |
| DK1169060T3 (da) * | 1999-04-09 | 2006-01-16 | Euro Celtique Sa | Natriumkanalblokkerpræparater og anvendelse deraf |
| ATE317280T1 (de) * | 2001-09-03 | 2006-02-15 | Newron Pharm Spa | Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung |
| KR101277520B1 (ko) * | 2004-09-10 | 2013-06-21 | 뉴론 파마슈티칼즈 에스. 피. 에이. | （할로벤질옥시）벤질아미노－프로판아미드를 포함하는 선택적 나트륨 및／또는 칼슘 채널 조절제로서 유용한 약제학적 조성물 |
| JP2018524302A (ja) * | 2015-06-12 | 2018-08-30 | ユニバーシティ オブ グリニッジ | インターフェロン‐γ阻害剤としてのトリアジン誘導体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3637688A (en) * | 1970-01-09 | 1972-01-25 | American Home Prod | 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines |
| US4310551A (en) * | 1979-03-19 | 1982-01-12 | Diamond Shamrock Corporation | Pharmacologically active substituted 1,2,4-triazines |
| IL60201A (en) * | 1979-06-01 | 1984-05-31 | Wellcome Found | 3-amino-6-(substituted)phenyl-1,2,4-triazine derivatives,their preparation and pharmaceutical compositions containing them |
| GB8613183D0 (en) * | 1986-05-30 | 1986-07-02 | Wellcome Found | Triazine salt |
| GB9012312D0 (en) * | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
-
1992
- 1992-02-19 GB GB929203483A patent/GB9203483D0/en active Pending
-
1993
- 1993-02-18 WO PCT/GB1993/000341 patent/WO1993016700A1/en not_active Ceased
- 1993-02-18 TW TW082101145A patent/TW226331B/zh active
- 1993-02-18 KR KR1019940702885A patent/KR950700067A/ko not_active Withdrawn
- 1993-02-18 IL IL10477593A patent/IL104775A/xx not_active IP Right Cessation
- 1993-02-18 NZ NZ249197A patent/NZ249197A/en unknown
- 1993-02-18 GB GB9414348A patent/GB2277265B/en not_active Revoked
- 1993-02-18 ES ES93904225T patent/ES2162813T3/es not_active Expired - Lifetime
- 1993-02-18 CA CA002129043A patent/CA2129043C/en not_active Expired - Fee Related
- 1993-02-18 AU AU35092/93A patent/AU684711B2/en not_active Ceased
- 1993-02-18 DE DE69330638T patent/DE69330638T2/de not_active Expired - Fee Related
- 1993-02-18 DK DK93904225T patent/DK0626851T3/da active
- 1993-02-18 PT PT93904225T patent/PT626851E/pt unknown
- 1993-02-18 AT AT93904225T patent/ATE204476T1/de not_active IP Right Cessation
- 1993-02-18 EP EP93904225A patent/EP0626851B1/en not_active Expired - Lifetime
- 1993-02-19 MX MX9300927A patent/MX9300927A/es not_active IP Right Cessation
-
1996
- 1996-07-15 US US08/680,111 patent/US5712277A/en not_active Expired - Fee Related
-
2001
- 2001-10-22 GR GR20010401827T patent/GR3036958T3/el not_active IP Right Cessation
-
2002
- 2002-10-14 CY CY0200058A patent/CY2299B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9300927A (es) | 1994-08-31 |
| CY2299B1 (en) | 2003-07-04 |
| DE69330638T2 (de) | 2002-06-27 |
| AU3509293A (en) | 1993-09-13 |
| GR3036958T3 (en) | 2002-01-31 |
| NZ249197A (en) | 1997-05-26 |
| TW226331B (es) | 1994-07-11 |
| JP3713271B2 (ja) | 2005-11-09 |
| EP0626851A1 (en) | 1994-12-07 |
| JPH07503968A (ja) | 1995-04-27 |
| US5712277A (en) | 1998-01-27 |
| EP0626851B1 (en) | 2001-08-22 |
| KR950700067A (ko) | 1995-01-16 |
| DE69330638D1 (de) | 2001-09-27 |
| GB2277265B (en) | 1996-01-10 |
| GB2277265A (en) | 1994-10-26 |
| AU684711B2 (en) | 1998-01-08 |
| IL104775A (en) | 1997-02-18 |
| GB9414348D0 (en) | 1994-09-07 |
| ES2162813T3 (es) | 2002-01-16 |
| PT626851E (pt) | 2002-02-28 |
| DK0626851T3 (da) | 2001-12-03 |
| WO1993016700A1 (en) | 1993-09-02 |
| ATE204476T1 (de) | 2001-09-15 |
| CA2129043A1 (en) | 1993-09-02 |
| GB9203483D0 (en) | 1992-04-08 |
| IL104775A0 (en) | 1993-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |