CA2121681A1 - Milieux de contraste contenant des particules de gel en vue d'une meilleure imagerie diagnostique - Google Patents

Milieux de contraste contenant des particules de gel en vue d'une meilleure imagerie diagnostique

Info

Publication number: CA2121681A1
Authority: CA; Canada
Prior art keywords: contrast medium; contrast; polymer; metal; acid
Prior art date: 1991-11-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA 2121681

Other languages

English (en)

Inventor

Evan C. Unger

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

ImaRx Pharmaceutical Corp

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-19

Filing date

1992-10-20

Publication date

1993-05-27

1992-10-20 Application filed by Individual filed Critical Individual

1993-05-27 Publication of CA2121681A1 publication Critical patent/CA2121681A1/fr

Status Abandoned legal-status Critical Current

Links

239000002872 contrast media Substances 0.000 title claims abstract description 128
239000007863 gel particle Substances 0.000 title claims abstract description 53
238000002059 diagnostic imaging Methods 0.000 title abstract description 4
229940039231 contrast media Drugs 0.000 title description 31
229920000642 polymer Polymers 0.000 claims abstract description 114
229910052751 metal Inorganic materials 0.000 claims abstract description 91
239000002184 metal Substances 0.000 claims abstract description 91
230000002708 enhancing effect Effects 0.000 claims abstract description 55
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239000010318 polygalacturonic acid Substances 0.000 claims description 55
229920001277 pectin Polymers 0.000 claims description 39
239000001814 pectin Substances 0.000 claims description 39
235000010987 pectin Nutrition 0.000 claims description 39
238000003384 imaging method Methods 0.000 claims description 38
150000002739 metals Chemical class 0.000 claims description 35
238000000034 method Methods 0.000 claims description 30
239000003349 gelling agent Substances 0.000 claims description 28
-1 polyethylenes Polymers 0.000 claims description 24
238000002595 magnetic resonance imaging Methods 0.000 claims description 18
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Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
- A61K49/0414—Particles, beads, capsules or spheres
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1803—Semi-solid preparations, e.g. ointments, gels, hydrogels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
- A61K49/1845—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a carbohydrate (monosaccharides, discacharides)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
- A61K49/1863—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Nanotechnology (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Radiology & Medical Imaging (AREA)
Public Health (AREA)
Physics & Mathematics (AREA)
Molecular Biology (AREA)
Acoustics & Sound (AREA)
Dispersion Chemistry (AREA)
Signal Processing (AREA)
High Energy & Nuclear Physics (AREA)
Condensed Matter Physics & Semiconductors (AREA)
General Physics & Mathematics (AREA)
Immunology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)

CA 2121681 1991-11-19 1992-10-20 Milieux de contraste contenant des particules de gel en vue d'une meilleure imagerie diagnostique Abandoned CA2121681A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US79443791A	1991-11-19	1991-11-19
US794,437		1991-11-19

Publications (1)

Publication Number	Publication Date
CA2121681A1 true CA2121681A1 (fr)	1993-05-27

Family

ID=25162622

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA 2121681 Abandoned CA2121681A1 (fr)	1991-11-19	1992-10-20	Milieux de contraste contenant des particules de gel en vue d'une meilleure imagerie diagnostique

Country Status (5)

Country	Link
EP (1)	EP0614527A4 (fr)
JP (1)	JPH07501331A (fr)
AU (1)	AU667491B2 (fr)
CA (1)	CA2121681A1 (fr)
WO (1)	WO1993010440A1 (fr)

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US5143716A (en) *	1991-02-01	1992-09-01	Unger Evan C	Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region
US5885549A (en) *	1991-02-01	1999-03-23	Imarx Pharmaceutical Corp.	Phosphorylated materials as contrast agents for use in magnetic resonance imaging of the gastrointestinal region
RU2114637C1 (ru) *	1991-09-17	1998-07-10	Сонус Фармасьютикалз, Инк.	Биосовместимая контрастная среда и способ получения ультразвукового изображения
US5409688A (en) *	1991-09-17	1995-04-25	Sonus Pharmaceuticals, Inc.	Gaseous ultrasound contrast media
MX9205298A (es) *	1991-09-17	1993-05-01	Steven Carl Quay	Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
IL108416A (en)	1993-01-25	1998-10-30	Sonus Pharma Inc	Colloids with phase difference as contrast ultrasound agents
US5310537A (en) *	1993-03-01	1994-05-10	Sterling Winthrop Inc.	Compositions of iodoaniline derivatives for visualization of the gastrointestinal tract
US5330740A (en) *	1993-03-01	1994-07-19	Sterling Winthrop Inc.	Compositions of iodoaniline derivatives in film-forming materials for visualization of the gastrointestinal tract
US20030100830A1 (en) *	2001-11-27	2003-05-29	Sheng-Ping Zhong	Implantable or insertable medical devices visible under magnetic resonance imaging
JP2005531647A (ja) *	2002-04-11	2005-10-20	カルボマーインク	新規なイメージングプローブ
DE10224352A1 (de) *	2002-06-01	2003-12-11	Mueller Schulte Detlef	Thermosensitive Polymerträger mit veränderbarer physikalischer Struktur für die biochemische Analytik, Diagnostik und Therapie
ES2396911T3 (es) *	2002-07-02	2013-03-01	Universitair Medisch Centrum Utrecht	Suspensión de barrido que comprende una partícula cuyo diámetro alcanza al menos 1 micrómetro
US20050065434A1 (en) *	2003-09-22	2005-03-24	Bavaro Vincent P.	Polymeric marker with high radiopacity for use in medical devices
US20050064223A1 (en)	2003-09-22	2005-03-24	Bavaro Vincent Peter	Polymeric marker with high radiopacity
NO320691B1 (no) *	2004-06-14	2006-01-16	Ntnu Technology Transfer As	Nytt kontrastfrigjorende system.

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US1985233A (en) *	1928-10-06	1934-12-25	Petroleum Conversion Corp	Process and apparatus for converting hydrocarbon oils
US4069306A (en) *	1974-03-14	1978-01-17	Pharmacia Aktiebolag	X-ray contrast preparation containing a hydrophilic polymer containing amino groups
US4452773A (en) *	1982-04-05	1984-06-05	Canadian Patents And Development Limited	Magnetic iron-dextran microspheres
US4735796A (en) *	1983-12-08	1988-04-05	Gordon Robert T	Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
GB8310038D0 (en) *	1983-04-13	1983-05-18	Amersham Int Plc	Technetium-99 labelled tin colloid
EP0146583B1 (fr) *	1983-06-09	1991-04-03	Field Group Chemicals Pty. Ltd.	Milieu opaque aux rayonnements
GB8408127D0 (en) *	1984-03-29	1984-05-10	Nyegaard & Co As	Contrast agents
US4749560A (en) *	1984-08-13	1988-06-07	Research Corporation	Metal organo phosphorous compounds for NMR analysis
DE3577185D1 (de) *	1984-11-01	1990-05-23	Nycomed As	Paramagnetische kontrastmittel fuer die anwendung in "in vivo" nmr-diagnostischen methoden und die herstellung davon.
DE3619746A1 (de) *	1986-06-12	1987-12-17	Basf Ag	Superparamagnetische feststoffteilchen
DE3709851A1 (de) *	1987-03-24	1988-10-06	Silica Gel Gmbh Adsorptions Te	Nmr-diagnostische fluessigkeitszusammensetzungen
GB8808305D0 (en) *	1988-04-08	1988-05-11	Nycomed As	Compositions
JPH04501265A (ja) *	1988-10-14	1992-03-05	マリンクロッド・インコーポレイテッド	ラジオ標識粒状組成物
US5358702A (en) *	1990-04-10	1994-10-25	Unger Evan C	Methoxylated gel particle contrast media for improved diagnostic imaging
WO1991015753A1 (fr) *	1990-04-10	1991-10-17	Unger Evan C	Polymeres utilises comme milieux de contraste en imagerie par resonance magnetique

1992
- 1992-10-20 WO PCT/US1992/008948 patent/WO1993010440A1/fr not_active Ceased
- 1992-10-20 JP JP5509251A patent/JPH07501331A/ja active Pending
- 1992-10-20 EP EP92922870A patent/EP0614527A4/fr not_active Withdrawn
- 1992-10-20 AU AU28940/92A patent/AU667491B2/en not_active Ceased
- 1992-10-20 CA CA 2121681 patent/CA2121681A1/fr not_active Abandoned

Also Published As

Publication number	Publication date
WO1993010440A1 (fr)	1993-05-27
JPH07501331A (ja)	1995-02-09
AU667491B2 (en)	1996-03-28
EP0614527A4 (fr)	1998-06-03
AU2894092A (en)	1993-06-15
EP0614527A1 (fr)	1994-09-14

Publication	Publication Date	Title
US5358702A (en)	1994-10-25	Methoxylated gel particle contrast media for improved diagnostic imaging
AU667491B2 (en)	1996-03-28	Gel particle contrast media for improved diagnostic imaging
KR100278513B1 (ko)	2001-01-15	이중 코팅을 갖는 철-함유 나노입자 및 진단 및 치료에 있어서의 그의 용도
EP0525199A1 (fr)	1993-02-03	Composition contenant des particules ultra fines d'oxyde de metal magnetique
AU628403B2 (en)	1992-09-17	Methods and compositions for magnetic resonance imaging
JPH07110815B2 (ja)	1995-11-29	画像及びスペクトル向上（およびスペクトルシフト）のためのポリキレ−ト剤
JPH01500196A (ja)	1989-01-26	臨床用途に使用される生物分解性超常磁性物質
EP0326226A1 (fr)	1989-08-02	Composés paramagnétiques
JPH05506227A (ja)	1993-09-16	磁気共鳴画像用造影剤としてのポリマー
Wang et al.	2020	Albumin-mediated synthesis of fluoroperovskite KMnF3 nanocrystals for T1-T2 dual-modal magnetic resonance imaging of brain gliomas with improved sensitivity
Stanicki et al.	2021	Impact of the chain length on the biodistribution profiles of PEGylated iron oxide nanoparticles: A multimodal imaging study
Wei et al.	2023	A tumor-associated bacteria-responsive magnetic exosome as a clearable T1 contrast agent for targeted imaging of tumors
JP4020784B2 (ja)	2007-12-12	常磁性金属−フタロシアニン錯化合物及びこれを利用した映像化用造影剤
US20090317327A1 (en)	2009-12-24	Aqueous Dispersion of Superparamagnetic Single-Domain Particles, Production and Use Thereof in Diagnosis and Therapy
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