CA2113614A1 - Methodes et compositions pour le traitement antimicrobien - Google Patents

Methodes et compositions pour le traitement antimicrobien

Info

Publication number: CA2113614A1
Authority: CA; Canada
Prior art keywords: bismuth subsalicylate; antimicrobial; treatment; safe; infection
Prior art date: 1991-07-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002113614A

Other languages

English (en)

Inventor

Scott Donald Whalen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Procter and Gamble Co

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-24

Filing date

1992-07-15

Publication date

1993-02-04

1992-07-15 Application filed by Individual filed Critical Individual

1993-02-04 Publication of CA2113614A1 publication Critical patent/CA2113614A1/fr

Status Abandoned legal-status Critical Current

Links

230000000845 anti-microbial effect Effects 0.000 title claims description 30
238000011282 treatment Methods 0.000 title claims description 29
239000000203 mixture Substances 0.000 title claims description 23
238000000034 method Methods 0.000 title abstract description 20
208000015181 infectious disease Diseases 0.000 claims abstract description 46
ZREIPSZUJIFJNP-UHFFFAOYSA-K bismuth subsalicylate Chemical compound C1=CC=C2O[Bi](O)OC(=O)C2=C1 ZREIPSZUJIFJNP-UHFFFAOYSA-K 0.000 claims abstract description 39
229960000782 bismuth subsalicylate Drugs 0.000 claims abstract description 39
239000004599 antimicrobial Substances 0.000 claims abstract description 29
241000193163 Clostridioides difficile Species 0.000 claims abstract description 9
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 8
239000000463 material Substances 0.000 claims description 6
229960000282 metronidazole Drugs 0.000 claims description 6
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 6
239000003937 drug carrier Substances 0.000 claims description 5
SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims description 4
229930182555 Penicillin Natural products 0.000 claims description 4
HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 claims description 4
MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 4
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NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 claims description 4
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FUBFWTUFPGFHOJ-UHFFFAOYSA-N 2-nitrofuran Chemical class [O-][N+](=O)C1=CC=CO1 FUBFWTUFPGFHOJ-UHFFFAOYSA-N 0.000 claims description 3
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 3
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LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 3
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AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims description 3
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QYIYFLOTGYLRGG-GPCCPHFNSA-N cefaclor Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 QYIYFLOTGYLRGG-GPCCPHFNSA-N 0.000 claims description 3
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IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
235000019366 oxytetracycline Nutrition 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
229940056360 penicillin g Drugs 0.000 description 1
229940056367 penicillin v Drugs 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
230000004260 plant-type cell wall biogenesis Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
238000001243 protein synthesis Methods 0.000 description 1
238000012552 review Methods 0.000 description 1
229960001225 rifampicin Drugs 0.000 description 1
JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
229960004025 sodium salicylate Drugs 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
241000894007 species Species 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000013589 supplement Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
238000012360 testing method Methods 0.000 description 1
OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
230000014616 translation Effects 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA002113614A 1991-07-24 1992-07-15 Methodes et compositions pour le traitement antimicrobien Abandoned CA2113614A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US73540091A	1991-07-24	1991-07-24
US735,400		1991-07-24

Publications (1)

Publication Number	Publication Date
CA2113614A1 true CA2113614A1 (fr)	1993-02-04

Family

ID=24955626

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002113614A Abandoned CA2113614A1 (fr)	1991-07-24	1992-07-15	Methodes et compositions pour le traitement antimicrobien

Country Status (10)

Country	Link
EP (1)	EP0595890A1 (fr)
JP (1)	JPH06509340A (fr)
AU (1)	AU2324392A (fr)
BR (1)	BR9206300A (fr)
CA (1)	CA2113614A1 (fr)
IE (1)	IE922403A1 (fr)
MA (1)	MA22597A1 (fr)
MX (1)	MX9204338A (fr)
PT (1)	PT100729A (fr)
WO (1)	WO1993001818A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AUPN771596A0 (en) *	1996-01-25	1996-02-15	Mclean, Allan Joseph	Methods of and compositions for potentiating the action of agents active on cell-wall sites of susceptible bacteria
DE10236347A1 (de) †	2002-08-08	2004-02-19	Basf Coatings Ag	Wäßrige Elektrotauchlacke, ihre Verwendung in Verfahren zur Beschichtung elektrisch leitfähiger Substrate sowie die Verwendung von Bismutverbindungen in diesen wäßrigen Elektrotauchlacken
AU2003263580A1 (en) *	2003-08-12	2005-02-25	Biocon Limited	Mycophenolic acid bismuth salt
US20170319603A1 (en) *	2016-03-24	2017-11-09	Paratek Pharmaceuticals, Inc.	Methods for treating and preventing c. difficile infection

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0707854B1 (fr) *	1985-06-13	2006-02-22	Barry James Dr. Marshall	Compositions pour le traitement des maladies gastrointestinales, contenant du bismuth et un agent antimicrobien
EP0439453B1 (fr) *	1987-10-12	1994-01-19	Exomed Australia Pty. Ltd. (ACN 051 976 446)	Procede ameliore servant au traitement de troubles gastrointestinaux

1992
- 1992-07-15 AU AU23243/92A patent/AU2324392A/en not_active Abandoned
- 1992-07-15 BR BR9206300A patent/BR9206300A/pt not_active Application Discontinuation
- 1992-07-15 JP JP5502889A patent/JPH06509340A/ja active Pending
- 1992-07-15 EP EP92915528A patent/EP0595890A1/fr not_active Withdrawn
- 1992-07-15 WO PCT/US1992/005848 patent/WO1993001818A1/fr not_active Ceased
- 1992-07-15 CA CA002113614A patent/CA2113614A1/fr not_active Abandoned
- 1992-07-21 MA MA22884A patent/MA22597A1/fr unknown
- 1992-07-23 MX MX9204338A patent/MX9204338A/es unknown
- 1992-07-23 IE IE240392A patent/IE922403A1/en not_active Application Discontinuation
- 1992-07-24 PT PT100729A patent/PT100729A/pt not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU2324392A (en)	1993-02-23
PT100729A (pt)	1993-10-29
EP0595890A1 (fr)	1994-05-11
IE922403A1 (en)	1993-01-27
BR9206300A (pt)	1994-08-02
WO1993001818A1 (fr)	1993-02-04
JPH06509340A (ja)	1994-10-20
MA22597A1 (fr)	1993-04-01
MX9204338A (es)	1993-03-01

Publication	Publication Date	Title
Marshall	1993	Treatment strategies for Helicobacter pylori infection
EP0616808B1 (fr)	1996-09-11	Emploi de la rifaximine et de ses compositions pharmaceutiques dans le traitement de la dyspepsie gastrique causée par l'helicobacter pylori
JP5469511B2 (ja)	2014-04-16	微生物の院内感染症の治療用医薬の製造におけるタウロリジンまたはタウラルタムのような抗微生物薬剤の使用
JPH0794390B2 (ja)	1995-10-11	胃腸疾患の治療のための医薬組成物
RO115780B1 (ro)	2000-06-30	Combinatie sinergica
KR19990022220A (ko)	1999-03-25	의료 용도의 미소-캡슐화된 락토바실러스
RU2116071C1 (ru)	1998-07-27	Лекарственные препараты, набор и способ лечения желудочно-кишечных заболеваний, вызываемых или опосредуемых заражением helicobaeter pylori
CN106620649A (zh)	2017-05-10	使用单剂量奥利万星的治疗方法
Cunha	1988	Nitrofurantoin—current concepts
JP2002500189A5 (fr)	2009-08-20
DE69125940T2 (de)	1997-12-18	Pharmazeutische zusammensetzungen die 5-difluormethoxy-2-[3,4-dimethoxy-2-pyridyl)methylsulfinyl]-1h-benzimidazol und ein anti-heliobactermittel enthalten zur behandlung von magen-darm krankheiten
CA2113614A1 (fr)	1993-02-04	Methodes et compositions pour le traitement antimicrobien
Graninger et al.	1996	Quinolones in gastrointestinal infections.
Fabian et al.	1985	Antibiotics in penetrating abdominal trauma: comparison of ticarcillin plus clavulanic acid with gentamicin plus clindamycin
WO2016081825A1 (fr)	2016-05-26	Procédés et compositions pour le traitement de maladie associée au clostridium difficile
US3949077A (en)	1976-04-06	Synergistic antibiotic compositions
Sartori et al.	1991	Acute gastroduodenal mucosal injury after cisplatin plus etoposide chemotherapy: clinical and endoscopic study
KR20010024050A (ko)	2001-03-26	항균제
EP0591446B1 (fr)	2000-09-13	Procede de traitement des gastrites a helicobacter pylori
Glupczynski	1990	In vitro susceptibility of Helicobacter pylori to antibiotics and bismuth salts and the importance of acquired resistance to antibiotics in treatment failures of H. pylori infection
Slack et al.	1987	The microbiological and pharmacokinetic profile of an antibacterial agent useful for the single-dose therapy of urinary tract infection
NAKAYA et al.	1982	Antimicrobial agents and intestinal microflora
Pimentel et al.	1998	Efficacy and safety of norfloxacin 800 mg once-daily versus norfloxacin 400 mg twice-daily in the treatment of uncomplicated urinary tract infections in women: a double-blind, randomized clinical trial
Sharma et al.	2023	Cefuroxime axetil: An oral prodrug of cefuroxime sodium
Schütz	1996	Efficacy and safety of sultamicillin (750 mg bid) compared with amoxycillin/clavulanate (625 mg tid) in patients with umcomplicated urinary tract infections

Legal Events

Date	Code	Title	Description
1994-01-17	EEER	Examination request
1997-07-15	FZDE	Dead