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CA2199002C - Micropores sur la peau humaine pour l'administration de medicaments et suivi medical - Google Patents

Micropores sur la peau humaine pour l'administration de medicaments et suivi medical

Info

Publication number
CA2199002C
CA2199002C CA002199002A CA2199002A CA2199002C CA 2199002 C CA2199002 C CA 2199002C CA 002199002 A CA002199002 A CA 002199002A CA 2199002 A CA2199002 A CA 2199002A CA 2199002 C CA2199002 C CA 2199002C
Authority
CA
Canada
Prior art keywords
tlle
selected area
stratum corneum
skin
light source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002199002A
Other languages
English (en)
Other versions
CA2199002A1 (fr
Inventor
Jonathan A. Eppstein
Michael R. Hatch
Defei Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Denko Corp
Original Assignee
Spectrx Inc
Altea Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrx Inc, Altea Technologies Inc filed Critical Spectrx Inc
Publication of CA2199002A1 publication Critical patent/CA2199002A1/fr
Application granted granted Critical
Publication of CA2199002C publication Critical patent/CA2199002C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3203—Fluid jet cutting instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00137—Details of operation mode
    • A61B2017/00154—Details of operation mode pulsed
    • A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A61B2018/0047—Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Surgical Instruments (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Laser Surgery Devices (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Méthode pour rendre la peau plus perméable à un analyte aux fins du diagnostic ou à un médicament à des fins thérapeutiques, qui fait appel à une technique de perçage d'un micropore et, facultativement, à l'énergie sonique et à un activateur chimique. Si l'on a recours à l'énergie sonique, celle-ci peut être modulée de différentes façons : modulation de fréquence, modulation d'amplitude, modulation de phase ou combinaisons de types de modulation. Pour percer un micropore, a) on enlève la couche cornée en chauffant rapidement en un point l'eau de façon à vaporiser l'eau et à éroder ainsi les cellules; b) on perfore la couche cornée avec une micro-lancette calibrée de façon à pratiquer un micropore pouvant atteindre environ 1 000 m de diamètre; c) on enlève la couche cornée en concentrant un faisceau bien focalisé d'énergie sonique sur la couche cornée; d) on perfore hydrauliquement la couche cornée avec un jet ou un liquide à haute pression pour former un micropore pouvant atteindre environ 1 000 m de diamètre, ou e) on perfore la couche cornée avec de brèves impulsions d'énergie électrique pour former un micropore pouvant atteindre environ 1 000 m de diamètre. Un colorant avec un maximum d'absorption correspondant à la longueur d'onde d'une source de lumière pulsée peut être absorbée dans la couche cornée pour concentrer l'énergie de la source de lumière pulsée et faciliter l'ablation de la couche cornée. Ou encore on peut mettre la couche cornée en contact avec un fil sous tension.
CA002199002A 1995-08-29 1996-08-29 Micropores sur la peau humaine pour l'administration de medicaments et suivi medical Expired - Lifetime CA2199002C (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52054795A 1995-08-29 1995-08-29
US08/520,547 1995-08-29
US804395P 1995-10-30 1995-10-30
US60/008,043 1995-10-30

Publications (2)

Publication Number Publication Date
CA2199002A1 CA2199002A1 (fr) 1997-03-01
CA2199002C true CA2199002C (fr) 1999-02-23

Family

ID=26677684

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002199002A Expired - Lifetime CA2199002C (fr) 1995-08-29 1996-08-29 Micropores sur la peau humaine pour l'administration de medicaments et suivi medical

Country Status (14)

Country Link
EP (1) EP0858285A4 (fr)
JP (2) JP3899427B2 (fr)
CN (1) CN1174713C (fr)
AU (1) AU707065B2 (fr)
BR (1) BR9610012A (fr)
CA (1) CA2199002C (fr)
ES (1) ES2536459T3 (fr)
GB (1) GB2307414B (fr)
HK (1) HK1009321A1 (fr)
IL (1) IL123379A (fr)
NO (1) NO334437B1 (fr)
PT (1) PT1563788E (fr)
TR (1) TR199800347T1 (fr)
WO (1) WO1997007734A1 (fr)

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WO1997007734A1 (fr) 1997-03-06
AU6863196A (en) 1997-03-19
EP0858285A1 (fr) 1998-08-19
ES2536459T3 (es) 2015-05-25
GB9702766D0 (en) 1997-04-02
JP2006192285A (ja) 2006-07-27
IL123379A0 (en) 1998-09-24
GB2307414B (en) 1998-03-11
AU707065B2 (en) 1999-07-01
PT1563788E (pt) 2015-06-02
BR9610012A (pt) 1999-12-21
CA2199002A1 (fr) 1997-03-01
JPH11511360A (ja) 1999-10-05
NO980878D0 (no) 1998-02-27
TR199800347T1 (xx) 1998-05-21
JP3899427B2 (ja) 2007-03-28
CN1195276A (zh) 1998-10-07
EP0858285A4 (fr) 2000-05-17
CN1174713C (zh) 2004-11-10
IL123379A (en) 2002-04-21
NO334437B1 (no) 2014-03-03
HK1009321A1 (en) 1999-05-28
GB2307414A (en) 1997-05-28

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