CA2198092C - Systeme therapeutique transdermique avec protection contre l'hydrolyse - Google Patents
Systeme therapeutique transdermique avec protection contre l'hydrolyse Download PDFInfo
- Publication number
- CA2198092C CA2198092C CA002198092A CA2198092A CA2198092C CA 2198092 C CA2198092 C CA 2198092C CA 002198092 A CA002198092 A CA 002198092A CA 2198092 A CA2198092 A CA 2198092A CA 2198092 C CA2198092 C CA 2198092C
- Authority
- CA
- Canada
- Prior art keywords
- transdermal therapeutic
- therapeutic system
- water
- active substance
- matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 32
- 230000007062 hydrolysis Effects 0.000 title claims abstract description 18
- 238000006460 hydrolysis reaction Methods 0.000 title claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 38
- 238000009739 binding Methods 0.000 claims abstract description 33
- 239000011159 matrix material Substances 0.000 claims abstract description 20
- 239000013543 active substance Substances 0.000 claims abstract description 18
- 239000010410 layer Substances 0.000 claims abstract 8
- 239000011241 protective layer Substances 0.000 claims abstract 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 10
- 239000011707 mineral Substances 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 9
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 8
- 238000004806 packaging method and process Methods 0.000 claims description 8
- 239000006185 dispersion Substances 0.000 claims description 7
- 238000003860 storage Methods 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 6
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 5
- -1 alkali metal salt Chemical class 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 239000002274 desiccant Substances 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 3
- UUOJIACWOAYWEZ-UHFFFAOYSA-N 1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate Chemical group C1=CC=C2NC(C)=CC2=C1OCC(CNC(C)(C)C)OC(=O)C1=CC=CC=C1 UUOJIACWOAYWEZ-UHFFFAOYSA-N 0.000 claims description 2
- ROGIWVXWXZRRMZ-UHFFFAOYSA-N 2-methylbuta-1,3-diene;styrene Chemical compound CC(=C)C=C.C=CC1=CC=CC=C1 ROGIWVXWXZRRMZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000004831 Hot glue Substances 0.000 claims description 2
- 229920002367 Polyisobutene Polymers 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 238000004220 aggregation Methods 0.000 claims description 2
- 230000002776 aggregation Effects 0.000 claims description 2
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- 229960001035 bopindolol Drugs 0.000 claims description 2
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 claims description 2
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 125000005273 2-acetoxybenzoic acid group Chemical group 0.000 claims 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 1
- 230000007246 mechanism Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 description 13
- 229940079593 drug Drugs 0.000 description 10
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 4
- 238000010348 incorporation Methods 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000003776 cleavage reaction Methods 0.000 description 3
- 230000003301 hydrolyzing effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 244000287680 Garcinia dulcis Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 150000001241 acetals Chemical class 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002313 adhesive film Substances 0.000 description 1
- 150000007854 aminals Chemical class 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000003797 solvolysis reaction Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4429663A DE4429663C2 (de) | 1994-08-20 | 1994-08-20 | Transdermales therapeutisches System mit Hydrolyseschutz |
| DEP4429663.0 | 1994-08-20 | ||
| PCT/EP1995/003204 WO1996006600A1 (fr) | 1994-08-20 | 1995-08-12 | Systeme therapeutique transdermique protege contre l'hydrolyse |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2198092A1 CA2198092A1 (fr) | 1996-03-07 |
| CA2198092C true CA2198092C (fr) | 2005-10-25 |
Family
ID=35311703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002198092A Expired - Fee Related CA2198092C (fr) | 1994-08-20 | 1995-08-12 | Systeme therapeutique transdermique avec protection contre l'hydrolyse |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2198092C (fr) |
-
1995
- 1995-08-12 CA CA002198092A patent/CA2198092C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2198092A1 (fr) | 1996-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH10505342A (ja) | 加水分解に対する保護を備えた経皮性治療システム | |
| KR960005142B1 (ko) | 활성 성분으로서 툴로부테롤을 함유하는 경피성 치료 시스템 | |
| CA2338859C (fr) | Emplatre contenant de l'estradiol pour l'administration transdermique d'hormones | |
| CA2147172C (fr) | Systeme therapeutique transdermique pour liberation de 17-.beta.-oestradiol, et mode de production | |
| HU221011B1 (hu) | Vízmentes 17béta-ösztradiolt tartalmazó transzdermális terápiás rendszer, valamint eljárás ennek előállítására | |
| US5932239A (en) | Transdermal therapeutic system with protection against hydrolysis | |
| WO2002078602A2 (fr) | Distribution transdermique de pergolide | |
| KR101259675B1 (ko) | 활성화 가능한 과포화 및 제어된 투과 촉진을 갖는 경피치료 시스템 | |
| CA2198092C (fr) | Systeme therapeutique transdermique avec protection contre l'hydrolyse | |
| KR100549846B1 (ko) | 활성물질 스코폴라민 염기를 함유하는 경피 치료 시스템 | |
| KR20030005435A (ko) | 비폐색성 배면층이 있는 폐색성 경피 치료 시스템 | |
| US5902602A (en) | Estradiol-TTS having water-binding additives | |
| CA2197865C (fr) | Systeme therapeutique transdermique renfermant de l'oestradiol et des additifs hydrophiles | |
| CA2197867C (fr) | Systeme therapeutique transdermique renfermant de l'oestradiol et des additifs hydrophiles | |
| AU762589B2 (en) | Estradiol-containing patch for transdermal administration of hormones | |
| HK1032194B (en) | Transdermal therapeutic system containing the active substance scopolamine base | |
| JPH0333687B2 (fr) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140812 |