[go: up one dir, main page]

CA2196182A1 - Derives aldehydes utilises comme inhibiteurs de protease d'upsteine - Google Patents

Derives aldehydes utilises comme inhibiteurs de protease d'upsteine

Info

Publication number
CA2196182A1
CA2196182A1 CA 2196182 CA2196182A CA2196182A1 CA 2196182 A1 CA2196182 A1 CA 2196182A1 CA 2196182 CA2196182 CA 2196182 CA 2196182 A CA2196182 A CA 2196182A CA 2196182 A1 CA2196182 A1 CA 2196182A1
Authority
CA
Canada
Prior art keywords
group
compound
stands
substituted
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2196182
Other languages
English (en)
Inventor
Takashi Sohda
Yukio Fujisawa
Tsuneo Yasuma
Junji Mizoguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2196182A1 publication Critical patent/CA2196182A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composé de la formule (Ia'). Dans cette formule, Q' représente un ou deux groupes acides aminés résiduels pouvant être substitués; R?1¿ représente un atome d'hydrogène ou un groupe hydrocarbure ou hétérocyclique facultativement substitué; R?4¿ représente un groupe carboxyle ou un groupe acyle facultativement estérifié; et X représente un groupe hydrocarbure divalent ramifié ou à chaîne linéaire facultativement substitués présentant une longueur de chaîne de 1 à 4 atomes comme fraction linéaire, ou un sel de cette substance, exerçant une puissante activité inhibitrice de la protéase de la cystéine et se révélant utile comme agent prophylactique et thérapeutique contre diverses maladies, notamment les maladies osseuses, causées par un déréglement de la protéase de la cystéine.
CA 2196182 1994-09-27 1995-09-25 Derives aldehydes utilises comme inhibiteurs de protease d'upsteine Abandoned CA2196182A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23183994 1994-09-27
JP6/231839 1994-09-27

Publications (1)

Publication Number Publication Date
CA2196182A1 true CA2196182A1 (fr) 1996-04-04

Family

ID=16929824

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2196182 Abandoned CA2196182A1 (fr) 1994-09-27 1995-09-25 Derives aldehydes utilises comme inhibiteurs de protease d'upsteine

Country Status (4)

Country Link
EP (1) EP0783489A1 (fr)
AU (1) AU3534195A (fr)
CA (1) CA2196182A1 (fr)
WO (1) WO1996010014A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0928786B1 (fr) * 1995-10-25 2003-01-02 Senju Pharmaceutical Co., Ltd. Inhibiteurs da la angiogenesis
US6214800B1 (en) 1995-10-25 2001-04-10 Senju Pharmaceutical Co., Ltd. Angiogenesis inhibitor
ATE230389T1 (de) 1995-10-25 2003-01-15 Senju Pharma Co Angiogenese inhibitoren
US7282512B2 (en) 2002-01-17 2007-10-16 Smithkline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227851A (ja) * 1983-06-09 1984-12-21 Sankyo Co Ltd レニン阻害作用を有するペプチド類
JPH03258800A (ja) * 1990-03-08 1991-11-19 Taisho Pharmaceut Co Ltd トリペプチド誘導体
JP2848232B2 (ja) * 1993-02-19 1999-01-20 武田薬品工業株式会社 アルデヒド誘導体

Also Published As

Publication number Publication date
EP0783489A1 (fr) 1997-07-16
AU3534195A (en) 1996-04-19
WO1996010014A1 (fr) 1996-04-04

Similar Documents

Publication Publication Date Title
EP0618926B1 (fr) Nouveaux derives de peptides
US5498728A (en) Derivatives of L-tryptophanal and their use as medicinals
AU772024B2 (en) Inhibitors of urokinase and blood vessel formation
FI112943B (fi) Pyrimidinyylijohdannaisia ja niiden käyttö lääkkeen valmistamiseksi interleukiini proteaasiaktiivisuuden inhiboimiseksi
EP0793673A1 (fr) Derives d'alpha-cetoamide utilises comme inhibiteurs de cathepsine l
IE873383L (en) Phosphinic acid derivatives
KR20000035925A (ko) 매트릭스 메탈로프로테아제 저해제인 포스핀산 아미드
FR2518088A1 (fr) Nouveaux derives d'aminoacides, et leur application therapeutique
CA2102890A1 (fr) Derives n-carboxyalkylpeptidyles substitues utilises comme agents antidegeneratifs
US6410684B1 (en) Serine protease inhibitors
DE69429642T2 (de) Lactol-Derivate, als Cathepsin L Inhibitoren
CA2196182A1 (fr) Derives aldehydes utilises comme inhibiteurs de protease d'upsteine
JPH08208462A (ja) カテプシンｌ阻害剤
JPH08104685A (ja) ラクトール誘導体、その製造法および用途
JPH08151355A (ja) アシルアミノアルデヒド誘導体およびその用途
EP0181644A2 (fr) Peptides amino-thioles
FR2537131A1 (fr) Nouveaux derives d'acides amines et leur application therapeutique
JPH04217995A (ja) ペプチド誘導体

Legal Events

Date Code Title Description
FZDE Dead