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CA2194010A1 - Systemes d'administration pulsee d'agents biologiquement actifs a l'aide d'impulsions de tension electrique permettant de reguler la permeabilite membranaire - Google Patents

Systemes d'administration pulsee d'agents biologiquement actifs a l'aide d'impulsions de tension electrique permettant de reguler la permeabilite membranaire

Info

Publication number
CA2194010A1
CA2194010A1 CA 2194010 CA2194010A CA2194010A1 CA 2194010 A1 CA2194010 A1 CA 2194010A1 CA 2194010 CA2194010 CA 2194010 CA 2194010 A CA2194010 A CA 2194010A CA 2194010 A1 CA2194010 A1 CA 2194010A1
Authority
CA
Canada
Prior art keywords
agent
drug
tissue
substance
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2194010
Other languages
English (en)
Inventor
Ooi Wong
Tung-Fen Chen
Russell O. Potts
Durairaj Bommi Bommannan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cygnus Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2194010A1 publication Critical patent/CA2194010A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Electrotherapy Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procédé d'entraînement pulsé d'une substance dans un tissu, consistant: (a) à soumettre le tissu à au moins une impulsion électrique afin de provoquer l'électroporation de la zone tissulaire, la durée de l'impulsion électrique étant égale à la durée d'impulsion d'électroporation, et la durée d'impulsion d'électroporation étant inférieure à la durée d'une force motrice; (b) à soumettre la zone tissulaire à une force motrice de sorte que celle-ci provoque l'entraînement pulsé de la substance dans le tissu, et ce pendant la durée de la force motrice; et (c) à répéter l'étape (a) pendant la durée de la force motrice.
CA 2194010 1994-06-24 1995-06-23 Systemes d'administration pulsee d'agents biologiquement actifs a l'aide d'impulsions de tension electrique permettant de reguler la permeabilite membranaire Abandoned CA2194010A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26530694A 1994-06-24 1994-06-24
US08/265,306 1994-06-24

Publications (1)

Publication Number Publication Date
CA2194010A1 true CA2194010A1 (fr) 1996-01-04

Family

ID=23009917

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2194010 Abandoned CA2194010A1 (fr) 1994-06-24 1995-06-23 Systemes d'administration pulsee d'agents biologiquement actifs a l'aide d'impulsions de tension electrique permettant de reguler la permeabilite membranaire

Country Status (5)

Country Link
EP (1) EP0766579A1 (fr)
JP (1) JPH10511008A (fr)
AU (1) AU2947795A (fr)
CA (1) CA2194010A1 (fr)
WO (1) WO1996000111A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6009345A (en) * 1992-08-17 1999-12-28 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
WO1998029134A2 (fr) * 1996-12-31 1998-07-09 Altea Technologies, Inc. Formation de micropores sur un tissu pour l'administration d'agents bioactifs
JP2002507985A (ja) 1997-06-30 2002-03-12 ローヌ−プーラン・ロレ・エス・アー 横紋筋に核酸を導入する改良法およびその組合せ
PL337584A1 (en) 1997-06-30 2000-08-28 Rhone Poulenc Rorer Sa Improved method of transferring nucleic acid to eucariotic cells of multiple-cell organisms and connection enabling accomplishment of this method
WO1999012606A1 (fr) * 1997-09-08 1999-03-18 Becton Dickinson And Company Administration par iontophorese de buprenorphine
TW368420B (en) * 1997-11-04 1999-09-01 Genetronics Inc Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
ATE220935T1 (de) * 1997-11-04 2002-08-15 Genetronics Inc Kombinierte elektroporation-und iontophoresevorrichtung zur medikament-und genverabreichung
US6778853B1 (en) 1997-12-17 2004-08-17 University Of South Florida Electroporation device
US6192270B1 (en) 1998-08-14 2001-02-20 Genetronics, Inc. Apparatus and method for the delivery of drugs and genes into tissue
US6148232A (en) * 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
AU765788B2 (en) * 1999-02-10 2003-10-02 Gmp Drug Delivery, Inc. Iontophoresis, electroporation and combination patches for local drug delivery
US7089053B1 (en) 1999-10-14 2006-08-08 Pola Chemical Industries Inc Compositions for drug administration by electroporation
JP4566496B2 (ja) * 1999-12-15 2010-10-20 ユニヴァーシティ オブ サウス フロリダ 電気穿孔素子及び電気穿孔方法
CA2468424A1 (fr) * 2001-11-27 2003-06-05 Cecilia Farre Procede d'administration parallele combinee d'agents et d'electroporation pour structures cellulaires et utilisation associee
US8232074B2 (en) 2002-10-16 2012-07-31 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
CA2520867A1 (fr) * 2003-04-02 2004-10-21 Colin E. Rowlings Antigenes et adjuvants a administration transdermique pulsatile
CN1905920A (zh) * 2003-11-13 2007-01-31 阿尔扎公司 用于透皮递送的系统和方法
DK1729746T3 (da) * 2004-03-19 2010-03-08 Mcneil Ab Anordning til transdermal administration af nikotin
EP2205967B1 (fr) 2007-10-17 2013-05-01 Syneron Medical Ltd. Vérification de la vitesse de dissolution

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3424753B2 (ja) * 1991-12-03 2003-07-07 アルザ コーポレーション イオン導入有効剤投与系
JPH0670987A (ja) * 1992-08-28 1994-03-15 Katsuro Tachibana 薬物投与・体液採取ユニット及び装置

Also Published As

Publication number Publication date
EP0766579A1 (fr) 1997-04-09
WO1996000111A1 (fr) 1996-01-04
AU2947795A (en) 1996-01-19
JPH10511008A (ja) 1998-10-27

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Legal Events

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