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CA2191612C - Procede pour preparer des fragments de cardiodilatine; fragments de cardiodilatine hautement purifies et produits intermediaires pour la preparation de ce procede - Google Patents

Procede pour preparer des fragments de cardiodilatine; fragments de cardiodilatine hautement purifies et produits intermediaires pour la preparation de ce procede Download PDF

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Publication number
CA2191612C
CA2191612C CA002191612A CA2191612A CA2191612C CA 2191612 C CA2191612 C CA 2191612C CA 002191612 A CA002191612 A CA 002191612A CA 2191612 A CA2191612 A CA 2191612A CA 2191612 C CA2191612 C CA 2191612C
Authority
CA
Canada
Prior art keywords
anp
fragments
amino acid
fragment
cardiodilatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002191612A
Other languages
English (en)
Other versions
CA2191612A1 (fr
Inventor
Hansueli Immer
Wolf-Georg Forssmann
Knut Adermann
Christian Klessen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardiopep Pharma GmbH
Original Assignee
Pharis Biotec GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharis Biotec GmbH filed Critical Pharis Biotec GmbH
Priority claimed from PCT/EP1995/002050 external-priority patent/WO1995033769A1/fr
Publication of CA2191612A1 publication Critical patent/CA2191612A1/fr
Application granted granted Critical
Publication of CA2191612C publication Critical patent/CA2191612C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un procédé et des produits intermédiaires utiles pour préparer des fragments de cardiodilatine, ainsi que des fragments très purs de cardiodilatine. L'invention concerne également des fragments très purs de cardiodilatine exempts d'impuretés peptidiques et qui présentent une seule crête de migration en électrophorèse capillaire, ainsi qu'un procédé de préparation de ces fragments.
CA002191612A 1994-06-02 1995-05-30 Procede pour preparer des fragments de cardiodilatine; fragments de cardiodilatine hautement purifies et produits intermediaires pour la preparation de ce procede Expired - Lifetime CA2191612C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DEP4420381.0 1994-06-02
DE4420381 1994-06-02
DE19513784A DE19513784A1 (de) 1994-06-02 1995-04-10 Hochreines Urodilatin und Verfahren zu seiner Herstellung
DE19513784.1 1995-04-10
PCT/EP1995/002050 WO1995033769A1 (fr) 1994-06-02 1995-05-30 Procede et produits intermediaires utiles pour preparer des fragments de cardiodilatine, et fragments tres purs de cardiodilatine

Publications (2)

Publication Number Publication Date
CA2191612A1 CA2191612A1 (fr) 1995-12-14
CA2191612C true CA2191612C (fr) 2007-10-23

Family

ID=6520321

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002191612A Expired - Lifetime CA2191612C (fr) 1994-06-02 1995-05-30 Procede pour preparer des fragments de cardiodilatine; fragments de cardiodilatine hautement purifies et produits intermediaires pour la preparation de ce procede

Country Status (4)

Country Link
CA (1) CA2191612C (fr)
DE (2) DE19513784A1 (fr)
TW (1) TW368505B (fr)
ZA (1) ZA954506B (fr)

Also Published As

Publication number Publication date
DE19513784A1 (de) 1995-12-07
DE59510439D1 (de) 2002-12-05
TW368505B (en) 1999-09-01
ZA954506B (en) 1996-12-02
CA2191612A1 (fr) 1995-12-14

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Effective date: 20150601