CA2186621A1 - Compose antimicrobien contenant de la lanthionine - Google Patents
Compose antimicrobien contenant de la lanthionineInfo
- Publication number
- CA2186621A1 CA2186621A1 CA002186621A CA2186621A CA2186621A1 CA 2186621 A1 CA2186621 A1 CA 2186621A1 CA 002186621 A CA002186621 A CA 002186621A CA 2186621 A CA2186621 A CA 2186621A CA 2186621 A1 CA2186621 A1 CA 2186621A1
- Authority
- CA
- Canada
- Prior art keywords
- peptide
- pharmaceutically acceptable
- peptide according
- acid addition
- acceptable acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- DWPCPZJAHOETAG-IMJSIDKUSA-N L-lanthionine Chemical compound OC(=O)[C@@H](N)CSC[C@H](N)C(O)=O DWPCPZJAHOETAG-IMJSIDKUSA-N 0.000 title claims abstract description 18
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- 150000003077 polyols Chemical class 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 238000011176 pooling Methods 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 238000000079 presaturation Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000005496 tempering Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 108010061238 threonyl-glycine Proteins 0.000 description 1
- 238000012582 total correlation spectroscopy experiment Methods 0.000 description 1
- UMFCIIBZHQXRCJ-NSCUHMNNSA-N trans-anol Chemical compound C\C=C\C1=CC=C(O)C=C1 UMFCIIBZHQXRCJ-NSCUHMNNSA-N 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 101150099695 vps11 gene Proteins 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 235000008939 whole milk Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
On décrit un peptide antimicrobien contenant de la lanthionine, susceptible d'être obtenu à partir de la souche 664 de Staphylococcus hyicus, les sels d'addition d'acide de ce peptide, acceptables sur le plan pharmacologique, de même que des compositions pharmaceutiques comprenant ce peptide ou les sels d'addition d'acide de celui-ci ainsi que des molécules d'ADN codant ledit peptide. On purifie ce peptide à partir d'un milieu de culture de souche 664 de Staphylococcus hyicus, et on peut l'utiliser dans un procédé de traitement ou de prévention de la mastite chez un mammifère, qui consiste à administrer audit mammifère une quantité, efficace sur le plan pharmacologique, du composé ou d'un des sels d'addition d'acide de celui-ci, afin de traiter efficacement la mastite ou de supprimer de façon sûre le taux, la sévérité et la durée de l'infection bactérienne consécutive à celle-ci.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9409200A GB9409200D0 (en) | 1994-05-07 | 1994-05-07 | Antimicrobial compound |
| GB9409200.4 | 1994-05-07 | ||
| GB9425886.0 | 1994-12-21 | ||
| GBGB9425886.0A GB9425886D0 (en) | 1994-12-21 | 1994-12-21 | Antimicrobial compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2186621A1 true CA2186621A1 (fr) | 1995-11-16 |
Family
ID=26304850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002186621A Abandoned CA2186621A1 (fr) | 1994-05-07 | 1995-04-26 | Compose antimicrobien contenant de la lanthionine |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0759077A1 (fr) |
| JP (1) | JPH09512711A (fr) |
| AU (1) | AU2408695A (fr) |
| CA (1) | CA2186621A1 (fr) |
| WO (1) | WO1995030751A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070003508A1 (en) | 2005-07-01 | 2007-01-04 | Wooley Richard E | Methods and compositions for promoting wound healing |
| NZ539076A (en) * | 2005-03-29 | 2008-05-30 | Blis Technologies Ltd | Skin treatment compositions |
| AU2007229275B2 (en) | 2006-03-23 | 2013-02-07 | Agriculture Victoria Services Pty Ltd | Antimicrobial protein |
| AR072350A1 (es) * | 2008-03-13 | 2010-08-25 | Agriculture Victoria Serv Pty | Peptidos que tienen actividad antimicrobiana al menos contra streptococcus uberis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3583987D1 (de) * | 1984-11-06 | 1991-10-10 | Thomae Gmbh Dr K | Antibiotisches polypeptid, verfahren zu seiner herstellung und seine verwendung. |
| GB8811760D0 (en) * | 1988-05-18 | 1988-06-22 | Thomae Gmbh Dr K | Antibiotic |
-
1995
- 1995-04-26 CA CA002186621A patent/CA2186621A1/fr not_active Abandoned
- 1995-04-26 JP JP7528644A patent/JPH09512711A/ja active Pending
- 1995-04-26 AU AU24086/95A patent/AU2408695A/en not_active Abandoned
- 1995-04-26 EP EP95917968A patent/EP0759077A1/fr not_active Withdrawn
- 1995-04-26 WO PCT/EP1995/001587 patent/WO1995030751A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995030751A1 (fr) | 1995-11-16 |
| AU2408695A (en) | 1995-11-29 |
| JPH09512711A (ja) | 1997-12-22 |
| EP0759077A1 (fr) | 1997-02-26 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Dead |