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CA2164961A1 - Glycosides fucosyles, inhibiteurs de l'adherence bacterienne - Google Patents

Glycosides fucosyles, inhibiteurs de l'adherence bacterienne

Info

Publication number
CA2164961A1
CA2164961A1 CA002164961A CA2164961A CA2164961A1 CA 2164961 A1 CA2164961 A1 CA 2164961A1 CA 002164961 A CA002164961 A CA 002164961A CA 2164961 A CA2164961 A CA 2164961A CA 2164961 A1 CA2164961 A1 CA 2164961A1
Authority
CA
Canada
Prior art keywords
beta
fuc
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alpha
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002164961A
Other languages
English (en)
Inventor
Karin Ingeborg Eklind
Hans Roland Lonn
Anna-Karin Ulla Edit Tiden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2164961A1 publication Critical patent/CA2164961A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Dérivés glycosidiques de mono, di, tri ou oligosaccharides présentant au moins un groupe terminal dérivé du L-fucose. Ces composés sont efficaces dans la thérapie ou la prophylaxie chez l'homme d'états relatifs à l'infection de la muqueuse gastrique par l'Heliobacter pylori; ainsi que leur méthode de préparation et celle de compositions pharmaceutiques les contenant.
CA002164961A 1993-06-25 1994-06-17 Glycosides fucosyles, inhibiteurs de l'adherence bacterienne Abandoned CA2164961A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK93761A DK76193D0 (da) 1993-06-25 1993-06-25 Kulhydratderivater
DK0761/93 1993-06-25

Publications (1)

Publication Number Publication Date
CA2164961A1 true CA2164961A1 (fr) 1995-01-05

Family

ID=8097261

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002164961A Abandoned CA2164961A1 (fr) 1993-06-25 1994-06-17 Glycosides fucosyles, inhibiteurs de l'adherence bacterienne

Country Status (9)

Country Link
EP (1) EP0706528A1 (fr)
JP (1) JPH08512026A (fr)
AU (1) AU7089194A (fr)
CA (1) CA2164961A1 (fr)
DK (1) DK76193D0 (fr)
IL (1) IL110074A0 (fr)
IS (1) IS4181A (fr)
LT (1) LT3446B (fr)
WO (1) WO1995000527A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014120799A1 (fr) * 2013-01-31 2014-08-07 Pioneer Hi-Bred International, Inc. Lipochitooligosaccharides synthétiques pour l'amélioration de la croissance et du rendement des plantes

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204431B1 (en) 1994-03-09 2001-03-20 Abbott Laboratories Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk
JPH1160590A (ja) * 1997-08-22 1999-03-02 Yakult Honsha Co Ltd オリゴフコース誘導体又はオリゴラムノース誘導体及びその製造法
SE9901007D0 (sv) * 1999-03-19 1999-03-19 Thomas Boren Use of fucosylated sialylated N-acetyl lactosamin carbohydrate structures for inhibition of bacterial adherence
JP5175190B2 (ja) * 2005-08-09 2013-04-03 グリコミメティクス， インコーポレイテッド シュードモナス由来のｐａ−ｉｌレクチン、ｐａ−ｉｉｌレクチンまたは両方のレクチンのグリコミメティック阻害剤
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
ES2655443T7 (es) 2011-12-22 2021-03-22 Glycomimetics Inc Compuestos antagonistas de E-selectina
EP2692740A1 (fr) * 2012-07-30 2014-02-05 Le Centre National De La Recherche Scientifique Compositions de glycane, leurs procédés de préparation et leurs utilisations en tant que médicament
LT2928476T (lt) 2012-12-07 2018-05-25 Glycomimetics, Inc. Junginiai, kompozicijos ir būdai, naudojant e-selektino antagonistus, hemopoetinių ląstelių mobilizacijai
US10086054B2 (en) * 2013-06-26 2018-10-02 Academia Sinica RM2 antigens and use thereof
ES2754549T3 (es) 2014-12-03 2020-04-20 Glycomimetics Inc Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4
US11045485B2 (en) 2016-01-22 2021-06-29 Glycomimetics, Inc. Glycomimetic inhibitors of PA-IL and PA-IIL lectins
WO2017151708A1 (fr) 2016-03-02 2017-09-08 Glycomimetics, Inc. Méthodes pour le traitement et/ou à la prévention de maladies cardiovasculaires par inhibition de la sélectine e
WO2018031445A1 (fr) 2016-08-08 2018-02-15 Glycomimetics, Inc. Combinaison d'inhibiteurs des points de contrôle des lymphocytes t avec des inhibiteurs de e-sélectine ou de cxcr4, ou avec des inhibiteurs hétérobifonctionnels de e-sélectine et de cxcr4
KR20240046288A (ko) 2016-10-07 2024-04-08 글리코미메틱스, 인크. 매우 강력한 다량체성 e-셀렉틴 길항물질
US11197877B2 (en) 2017-03-15 2021-12-14 Glycomimetics. Inc. Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
US11712446B2 (en) 2017-11-30 2023-08-01 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
US11548908B2 (en) 2017-12-29 2023-01-10 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
BR112020018184A2 (pt) 2018-03-05 2021-02-02 Glycomimetics, Inc. usos de compostos
EP3841123A2 (fr) 2018-08-23 2021-06-30 Seagen Inc. Anticorps anti-tigit
CN118373810A (zh) 2018-12-27 2024-07-23 糖模拟物有限公司 抑制c-糖苷的半乳凝素-3
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1603609A (en) * 1977-04-14 1981-11-25 Chembiomed Ltd O-protected 2-azido-2-deoxy-glycosyl nitrates
FR2509313A1 (fr) * 1981-07-08 1983-01-14 Choay Sa Derives de 3-fucosyl-n-acetyl lactosamine, leur preparation et leurs applications biologiques
DE3220427A1 (de) * 1982-05-29 1983-12-01 Behringwerke Ag, 3550 Marburg Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung
DK17685D0 (da) * 1985-01-14 1985-01-14 Hans Goeran Magnusson Glycosidderivater
EP0348143A3 (fr) * 1988-06-21 1991-03-13 MARION LABORATORIES, INC. (a Delaware corporation) Dérivés de bismuth de phosphates et sulphates de saccharides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014120799A1 (fr) * 2013-01-31 2014-08-07 Pioneer Hi-Bred International, Inc. Lipochitooligosaccharides synthétiques pour l'amélioration de la croissance et du rendement des plantes
CN105101972A (zh) * 2013-01-31 2015-11-25 先锋国际良种公司 用于改善植物生长和产量的合成型脂质几丁寡糖

Also Published As

Publication number Publication date
AU7089194A (en) 1995-01-17
JPH08512026A (ja) 1996-12-17
EP0706528A1 (fr) 1996-04-17
DK76193D0 (da) 1993-06-25
IL110074A0 (en) 1994-10-07
LT3446B (en) 1995-10-25
WO1995000527A1 (fr) 1995-01-05
LTIP1978A (en) 1995-01-31
IS4181A (is) 1994-12-26

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Legal Events

Date Code Title Description
FZDE Discontinued