[go: up one dir, main page]

CA2147598A1 - Morphogenese induite par op-3 - Google Patents

Morphogenese induite par op-3

Info

Publication number
CA2147598A1
CA2147598A1 CA002147598A CA2147598A CA2147598A1 CA 2147598 A1 CA2147598 A1 CA 2147598A1 CA 002147598 A CA002147598 A CA 002147598A CA 2147598 A CA2147598 A CA 2147598A CA 2147598 A1 CA2147598 A1 CA 2147598A1
Authority
CA
Canada
Prior art keywords
seq
amino acid
tissue
protein
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002147598A
Other languages
English (en)
Inventor
Hermann Oppermann
Engin Ozkaynak
Thangavel Kuberasampath
David C. Rueger
Roy H. L. Pang
Charles M. Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stryker Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2147598A1 publication Critical patent/CA2147598A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00Preparations for dentistry
    • A61K6/50Preparations specially adapted for dental root treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00365Proteins; Polypeptides; Degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002147598A 1992-11-03 1993-11-02 Morphogenese induite par op-3 Abandoned CA2147598A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US97109192A 1992-11-03 1992-11-03
US971,091 1992-11-03
US2933593A 1993-03-04 1993-03-04
US4051093A 1993-03-31 1993-03-31

Publications (1)

Publication Number Publication Date
CA2147598A1 true CA2147598A1 (fr) 1994-05-11

Family

ID=27363460

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002147598A Abandoned CA2147598A1 (fr) 1992-11-03 1993-11-02 Morphogenese induite par op-3

Country Status (5)

Country Link
EP (1) EP0672064A1 (fr)
JP (1) JPH08503198A (fr)
AU (1) AU681362B2 (fr)
CA (1) CA2147598A1 (fr)
WO (1) WO1994010203A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972703A (en) * 1994-08-12 1999-10-26 The Regents Of The University Of Michigan Bone precursor cells: compositions and methods
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
US6281195B1 (en) 1997-02-07 2001-08-28 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
DK0980252T3 (da) 1997-05-05 2005-01-31 Curis Inc Terapier til akut nyresvigt
US20030032586A1 (en) * 1997-05-15 2003-02-13 David C. Rueger Compositions for morphogen-induced osteogenesis
EP0985149A1 (fr) 1997-05-30 2000-03-15 Creative Biomolecules, Inc. Procedes pour evaluer la morphogenese des tissus et leur activite
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
ATE478008T1 (de) 2004-03-10 2010-09-15 Scil Technology Gmbh Überzogene implantate, ihre herstellung und verwendung davon
ATE515268T1 (de) 2004-05-25 2011-07-15 Stryker Corp Verwendung von op-1 zur behandlung von knorpeldefekten
AU2007257208B2 (en) 2006-05-17 2013-05-02 Stryker Corporation Use of a soluble morphogenic protein complex for treating cartilage defects
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
WO2008082563A2 (fr) 2006-12-21 2008-07-10 Stryker Corporation Formulations à libération entretenue comprenant des cristaux, des gels macromoléculaires et des suspensions particulaires d'agents biologiques
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US8058237B2 (en) 2007-08-07 2011-11-15 Advanced Technologies & Regenerative Medicine, LLC Stable composition of GDF-5 and method of storage
EP2268302B1 (fr) 2008-02-13 2014-04-09 Keith Hruska Bmp-7 pour le traitement de l'hyperplasie néointimale
CN102026619A (zh) 2008-04-14 2011-04-20 先进科技及再生医学有限责任公司 液体缓冲的gdf-5制剂
SG173632A1 (en) 2009-02-12 2011-09-29 Stryker Corp Peripheral administration of proteins including tgf-beta superfamily members for systemic treatment of disorders and disease
WO2010093941A2 (fr) 2009-02-12 2010-08-19 Stryker Corporation Composition et procédés d'administration systémique les moins invasifs possibles de protéines comprenant des membres de la superfamille des tgf-β
WO2010110974A1 (fr) 2009-03-24 2010-09-30 Stryker Corporation Procédés et compositions pour l'ingénierie tissulaire
WO2011031856A1 (fr) 2009-09-09 2011-03-17 Stryker Corporation Bmp-7 à utiliser dans le traitement de la douleur induite par les lésions et les maladies d'articulation
AU2010295509A1 (en) 2009-09-17 2012-04-19 Stryker Corporation Buffers for controlling the pH of bone morphogenetic proteins
EP2516456A1 (fr) 2009-12-22 2012-10-31 Stryker Corporation Variants de la bmp-7 dotés d'une immunogénicité réduite
DK2797609T3 (en) 2011-12-30 2017-01-09 Innomed S A COMBINING growth factors, cytokines, anti-bacterial / ANTIVIRALS FACTORS STEM CELL-STIMULATING FACTORS, complement C3A / C4A, immunoglobulins, and chemotactic factors
ITMI20112437A1 (it) * 2011-12-30 2013-07-01 Bionest Ltd Uso di citochine, fattori di crescita e fattori antibatterici come materiale di sottofondo di cavita' per la terapia della carie penetrante dei denti e dell'infiammazione pulpare
RU2645082C2 (ru) * 2011-12-30 2018-02-15 Инномед С.А. Комбинация факторов роста, цитокинов, антибактериальных/антивирусных факторов, факторов стволовых клеток, белков комплемента с3а/с4а и хемотаксических факторов

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68929453T2 (de) * 1988-04-08 2003-11-20 Stryker Corp., Kalamazoo Osteogene Vorrichtungen
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
US5011961A (en) * 1990-06-13 1991-04-30 Dow Corning Limited Method of making organosilbutadiyne polymers
AU660019B2 (en) * 1991-03-11 1995-06-08 Stryker Corporation Protein-induced morphogenesis
DE69233559T2 (de) * 1991-08-30 2006-08-31 Curis, Inc., Cambridge Osteogenische proteine in der behandlung von metabolischen knochenkrankheiten
AU678380B2 (en) * 1992-07-31 1997-05-29 Stryker Corporation Morphogenic protein soluble complex and composition thereof

Also Published As

Publication number Publication date
EP0672064A1 (fr) 1995-09-20
WO1994010203A2 (fr) 1994-05-11
WO1994010203A3 (fr) 1994-08-18
AU5590094A (en) 1994-05-24
JPH08503198A (ja) 1996-04-09
AU681362B2 (en) 1997-08-28

Similar Documents

Publication Publication Date Title
AU681362B2 (en) OP-3-induced morphogenesis
AU660019B2 (en) Protein-induced morphogenesis
EP0653942B1 (fr) Regeneration et reparation du systeme nerveux induites par morphogene
US5854071A (en) OP-3- induced morphongenesis
US6565843B1 (en) Protein-induced tissue morphogenesis
EP0646022B1 (fr) Protheses a proprietes osteogenes accrues
US5674844A (en) Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6800603B2 (en) Morphogen-induced neural cell adhesion
US5652118A (en) Nucleic acid encoding a novel morphogenic protein, OP-3
US6949505B1 (en) Morphogen-induced dendritic growth
EP0661987B1 (fr) Regeneration du foie induite par des morphogenes
US6495513B1 (en) Morphogen-enhanced survival and repair of neural cells
WO1992007004A1 (fr) Proteine osteogenique
US6211146B1 (en) 60A protein-induced morphogenesis
WO1994006447A2 (fr) Morphogenese induite par la proteine 60a
AU670334B2 (en) Morphogen-induced periodontal tissue regeneration

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued