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CA2019863A1 - Suspension aqueuse pharmaceutique pour des ingredients actifs pharmaceutiques peu hydrosolubles - Google Patents

Suspension aqueuse pharmaceutique pour des ingredients actifs pharmaceutiques peu hydrosolubles

Info

Publication number
CA2019863A1
CA2019863A1 CA2019863A CA2019863A CA2019863A1 CA 2019863 A1 CA2019863 A1 CA 2019863A1 CA 2019863 A CA2019863 A CA 2019863A CA 2019863 A CA2019863 A CA 2019863A CA 2019863 A1 CA2019863 A1 CA 2019863A1
Authority
CA
Canada
Prior art keywords
water insoluble
substantially water
suspension
pharmaceutical
aqueous pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2019863A
Other languages
English (en)
Other versions
CA2019863C (fr
Inventor
Walter G. Gowan, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kenvue Brands LLC
Original Assignee
McNeil PPC Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeil PPC Inc filed Critical McNeil PPC Inc
Publication of CA2019863A1 publication Critical patent/CA2019863A1/fr
Application granted granted Critical
Publication of CA2019863C publication Critical patent/CA2019863C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002019863A 1989-06-28 1990-06-26 Suspension aqueuse pharmaceutique pour des ingredients actifs pharmaceutiques peu hydrosolubles Expired - Lifetime CA2019863C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37273489A 1989-06-28 1989-06-28
US372,734 1989-06-28

Publications (2)

Publication Number Publication Date
CA2019863A1 true CA2019863A1 (fr) 1990-12-28
CA2019863C CA2019863C (fr) 1996-06-04

Family

ID=23469412

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002019863A Expired - Lifetime CA2019863C (fr) 1989-06-28 1990-06-26 Suspension aqueuse pharmaceutique pour des ingredients actifs pharmaceutiques peu hydrosolubles

Country Status (17)

Country Link
US (2) US5374659A (fr)
EP (1) EP0405930B1 (fr)
JP (1) JP2874967B2 (fr)
KR (1) KR0161969B1 (fr)
AT (1) ATE110259T1 (fr)
AU (1) AU635283B2 (fr)
CA (1) CA2019863C (fr)
DE (1) DE69011766T2 (fr)
ES (1) ES2064634T3 (fr)
GR (1) GR1002094B (fr)
GT (1) GT199000066A (fr)
HK (1) HK127494A (fr)
IE (1) IE64400B1 (fr)
IL (1) IL94887A (fr)
NZ (1) NZ234143A (fr)
PT (1) PT94504B (fr)
ZA (1) ZA905058B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9399013B2 (en) 2006-05-19 2016-07-26 Norbrook Laboratories Limited Stable aqueous suspension

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5496563A (en) * 1991-08-30 1996-03-05 Showa Yakuhin Kako Co., Ltd. Dry gel composition
US5605930A (en) * 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
NO941358L (no) * 1993-04-16 1994-10-17 Mcneil Ppc Inc Vandig farmasöytisk suspensjon og fremgangsmåte for fremstilling derav
FR2713931B1 (fr) * 1993-12-20 1996-04-05 Laurence Paris Nouvelles compositions pharmaceutiques liquides à base d'ibuprofène et leur procédé de préparation.
NZ272574A (en) * 1995-07-14 1999-02-25 Lilly Eli & Co Nz Ltd Aqueous base suspension concentrate containing at least one ionophore antibiotic and wetting agent and/or a surfactant and xanthan gum optionally with a suspension agent, an antifreeze agent and an antifoaming agent; drench for veterinary treatment
DE69632257T2 (de) * 1995-07-14 2005-04-28 Eli Lilly & Co. (Nz) Ltd., Manukau Formulierungen mit monensin
NZ280384A (en) 1995-11-02 1997-01-29 Lilly Eli & Co Nz Ltd Animal feed supplement comprising a wettable powder composition of an ionophore antibiotic
AUPN862596A0 (en) * 1996-03-12 1996-04-04 F.H. Faulding & Co. Limited Pharmaceutical compositions
CA2253260A1 (fr) * 1996-05-02 1997-11-13 Taisho Pharmaceutical Co., Ltd. Suspension de medicament acide difficilement soluble dans l'eau
US5712310A (en) * 1996-06-14 1998-01-27 Alpharma Uspd, Inc. Suspension of substantially water-insoluble drugs and methods of their manufacture
EP1210880B8 (fr) 1998-10-28 2009-06-03 San-Ei Gen F.F.I., Inc. Compositions contenant la sucralose et leur utilisation
US20110189348A1 (en) * 1998-10-28 2011-08-04 San-Ei Gen F.F.I., Inc. Compositions containing sucralose and application thereof
USH2044H1 (en) 1998-11-02 2002-09-03 Mcneil-Ppc, Inc. Container with retaining member
PT1165042E (pt) 1999-04-06 2005-06-30 Ethypharm Sa Suspensao farmaceutica bebivel de ibuprofeno
US6211246B1 (en) * 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
US6726922B1 (en) 1999-06-28 2004-04-27 Minu, L.L.C. Process and composition for temporarily suppressing pain
WO2001091585A2 (fr) 2000-05-31 2001-12-06 Pepsico, Inc. Composition de coloration alimentaire orange a faible intensite de coloration
CN1446316A (zh) * 2000-08-02 2003-10-01 玛洛普有限公司 基于下丘脑－垂体－肾上腺轴异常的非溃疡性消化不良的诊断和处置
JP4204864B2 (ja) * 2000-12-25 2009-01-07 ライオン株式会社 懸濁液の安定化方法及び安定化された懸濁液
EP1232746B1 (fr) * 2001-02-14 2006-06-14 Forte IQ B.V. Composition pharmaceutique contenant de la gomme de xanthane
JP2004535370A (ja) * 2001-03-05 2004-11-25 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 味をマスクした液体製薬学的組成物
EP2090165A3 (fr) * 2001-04-03 2012-03-28 Schering Corporation Composition antifongique avec une biodisponibilité améliorée
EP1411955A4 (fr) * 2001-07-31 2006-07-05 Wyeth Corp Preparation de sucralose permettant de masquer des gouts desagreables
US6770263B1 (en) * 2001-10-01 2004-08-03 Naturewell, Incorporated Compositions and methods for the treatment of aches and pains
US20040132823A1 (en) * 2001-11-02 2004-07-08 Leo Pavliv Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid
ES2197781B1 (es) * 2001-12-04 2005-02-16 Farmalider, S.A. Composiciones farmaceuticas liquidas de base acuosa en forma de suspension para la administracion por via oral de ibuprofeno.
US7049435B2 (en) 2002-03-08 2006-05-23 Tate & Lyle Public Limited Company Extractive methods for purifying sucralose
US6998480B2 (en) 2002-03-08 2006-02-14 Tate & Lyle Public Limited Company Process for improving sucralose purity and yield
US7300670B2 (en) 2002-04-03 2007-11-27 Unilab Pharmatech, Ltd. Oral suspension formulation
AU2003238221A1 (en) * 2002-06-17 2003-12-31 Taro Pharmaceuticals U.S.A, Inc. Ibuprofen suspension
US20030232097A1 (en) * 2002-06-17 2003-12-18 Strides Inc. Oily wax matrix suspension formulation comprising ibuprofen free acid and potassium salt of ibuprofen
KR100509432B1 (ko) * 2002-12-13 2005-08-22 주식회사 동구제약 Ｓ(+)-이부프로펜을 함유한 시럽제 조성물 및 그의 제조방법
US7863287B2 (en) * 2002-12-18 2011-01-04 Wyeth Llc Compositions of non-steroidal anti-inflammatory drugs, decongestants and anti-histamines
US20040253311A1 (en) * 2002-12-18 2004-12-16 Roger Berlin Multi-layer tablet comprising non-steroidal anti-inflammatory drugs, decongestants and non-sedating antihist amines
US20040186180A1 (en) * 2003-03-21 2004-09-23 Gelotte Cathy K. Non-steroidal anti-inflammatory drug dosing regimen
WO2005025622A1 (fr) * 2003-09-12 2005-03-24 Ryukakusan Co. Ltd. Boisson a base de gelee particulaire, masquant l'amertume
US20050069590A1 (en) * 2003-09-30 2005-03-31 Buehler Gail K. Stable suspensions for medicinal dosages
US20050095300A1 (en) * 2003-10-30 2005-05-05 Wynn David W. Controlled release analgesic suspensions
US20050095299A1 (en) * 2003-10-30 2005-05-05 Wynn David W. Controlled release analgesic suspensions
US20070190133A1 (en) * 2004-10-27 2007-08-16 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060088586A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060088593A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060087051A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060088587A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US8383159B2 (en) * 2004-10-27 2013-02-26 Mcneil-Ppc, Inc. Dosage forms having a microreliefed surface and methods and apparatus for their production
US20070281022A1 (en) * 2004-10-27 2007-12-06 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060093630A1 (en) * 2004-10-29 2006-05-04 Buehler Gail K Dye-free pharmaceutical suspensions and related methods
US20060093629A1 (en) * 2004-10-29 2006-05-04 Buehler Gail K Dye-free pharmaceutical suspensions and related methods
US20060093631A1 (en) * 2004-10-29 2006-05-04 Buehler Gail K Dye-free pharmaceutical suspensions and related methods
US20060094760A1 (en) * 2004-11-04 2006-05-04 Fawzy Abdel A Composition, system and method of treatment of gastrointestinal disorders with nizatidine oral solution
US7611695B2 (en) * 2004-11-15 2009-11-03 Ultradent Products, Inc. Flavored hemostatic and acid etching compositions
US8758816B2 (en) * 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
PL2486942T3 (pl) 2004-11-24 2019-05-31 Meda Pharmaceuticals Inc Kompozycje zawierające azelastynę oraz sposoby ich stosowania
CA2586288A1 (fr) * 2004-12-06 2006-06-15 Janssen Pharmaceutica Nv Suspension orale contenant du meloxicam
EP2018160B1 (fr) 2006-03-16 2011-12-14 Tris Pharma, Inc. Formulations a liberation modifiee contenant des complexes medicament - resine echangeuse d'ions
US20080014275A1 (en) * 2006-07-13 2008-01-17 Buehler Gail K Pharmaceutical suspensions and related methods
WO2008064192A2 (fr) 2006-11-21 2008-05-29 Mcneil-Ppc, Inc. Suspensions analgésiques à libération modifiée
US8895061B2 (en) * 2007-03-02 2014-11-25 Meda Pharmaceuticals Inc. Compositions comprising carisoprodol and methods of use thereof
WO2008112113A1 (fr) * 2007-03-09 2008-09-18 Hercules Incorporated Suspensions polymères fluidifiée à base de thiosulfate de sodium stables de cellulose hydroxyéthylique pour des services de champ pétrolifère
US20080260837A1 (en) * 2007-04-20 2008-10-23 Qpharma, L.L.C. Physically stable aqueous suspensions of active pharmaceuticals
US20080268025A1 (en) * 2007-04-25 2008-10-30 Donald Spector Compositions Useful for Preventing Pain and Soreness Resulting from Exercise and Methods of Use
US9833510B2 (en) * 2007-06-12 2017-12-05 Johnson & Johnson Consumer Inc. Modified release solid or semi-solid dosage forms
US20090162923A1 (en) 2007-12-20 2009-06-25 Young Jeffrey W Methods and Compositions for Digestion of Organic Waste
EP2231138A1 (fr) * 2008-01-03 2010-09-29 Wockhardt Research Centre Suspension pharmaceutique orale contenant du paracétamol et de l'ibuprofène
US8436156B2 (en) * 2008-01-04 2013-05-07 Tate & Lyle Technology Limited Method for the production of sucralose
WO2009117317A1 (fr) * 2008-03-20 2009-09-24 Tate & Lyle Technology Ltd Élimination d’acides de solvants amide tertiaire
US8436157B2 (en) * 2008-03-26 2013-05-07 Tate & Lyle Technology Limited Method for the production of sucralose
US20090299055A1 (en) * 2008-04-03 2009-12-03 Tate & Lyle Technology Limited Purification of Sucralose Containing Feed Streams for Sucralose Crystallization
US20090259036A1 (en) * 2008-04-03 2009-10-15 Tate & Lyle Technology Limited Extraction of less polar impurities from sucralose containing aqueous feed streams
TW200946683A (en) * 2008-04-03 2009-11-16 Tate & Lyle Technology Ltd A process for the purification of aqueous feed streams containing sucralose extraction efficiency
US8497367B2 (en) * 2008-04-03 2013-07-30 Tate & Lyle Technology Limited Sucralose purification process
AR071134A1 (es) * 2008-04-03 2010-05-26 Tate & Lyle Technology Ltd Cristalizacion de sucralosa a partir de chorros que contienen sucralosa
SG10201914059WA (en) 2008-10-22 2020-03-30 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
WO2010103384A1 (fr) * 2009-03-13 2010-09-16 Nucitec S.A. De C.V. Compositions et méthodes de traitement et prévention de maladies cardiovasculaires
GB2469158B (en) 2009-03-31 2011-09-28 Peter J Seaberg Base-assisted formation of tin-sucrose adducts
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
GB2474310B (en) 2009-10-12 2012-02-29 Tate & Lyle Technology Ltd Process for the production of sucrose-6-ester
GB2474311B (en) * 2009-10-12 2012-10-17 Tate & Lyle Technology Ltd Low temperature, single solvent process for the production of sucrose-6-ester
GB201110520D0 (en) 2011-05-10 2011-08-03 Tate & Lyle Technology Ltd Extraction of carboxylic acids with tin compounds
JP6532937B2 (ja) 2014-05-05 2019-06-19 カル セーフ ソイル， エルエルシー 栄養豊富な組成物
US10799505B2 (en) 2014-11-16 2020-10-13 Array Biopharma, Inc. Crystalline form of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-A]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
EP3061501A1 (fr) 2015-02-27 2016-08-31 Rottapharm Ltd. Composition pour le traitement de l'acné
EP3117825A1 (fr) 2015-07-16 2017-01-18 Rottapharm S.p.A. Formulation orale comprenant de la berbérine et un extrait de morus alba
US11590228B1 (en) 2015-09-08 2023-02-28 Tris Pharma, Inc Extended release amphetamine compositions
JP2018534296A (ja) 2015-10-26 2018-11-22 ロクソ オンコロジー， インコーポレイテッドＬｏｘｏ Ｏｎｃｏｌｏｇｙ， Ｉｎｃ． Ｔｒｋ阻害薬耐性がんにおける点変異およびそれに関連する方法
MX386416B (es) 2016-04-04 2025-03-18 Loxo Oncology Inc Formulaciones liquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida.
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
HUE063877T2 (hu) 2016-05-18 2024-02-28 Loxo Oncology Inc (S)-N-(5-((R)-2-(2,5-dlfluorofenil)pirolidin-1-il)plrazolo[1,5-A]pirimidin-3-il) -3-hidroxipirolidin-1-karboxamid elõállítása
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
US20200206352A1 (en) * 2017-08-31 2020-07-02 Tohoku University Optimal osmotic range for a drug-containing solution suitable for lymphatic delivery
US11590081B1 (en) 2017-09-24 2023-02-28 Tris Pharma, Inc Extended release amphetamine tablets
US12458592B1 (en) 2017-09-24 2025-11-04 Tris Pharma, Inc. Extended release amphetamine tablets
MA50456A (fr) * 2017-10-26 2020-09-02 Array Biopharma Inc Formulations d'un inhibiteur de kinase trk macrocyclique
GB2585825B (en) * 2019-07-09 2023-03-22 Lexon Uk Holdings Ltd Suspending vehicle formulation
HRP20240108T1 (hr) * 2019-12-23 2024-04-12 Nutra Essential Otc, S.L. Tekući sastav koji sadrži ibuprofen i fenilefrin
CN112516083B (zh) * 2020-12-15 2023-02-28 太阳升(亳州)生物医药科技有限公司 布洛芬混悬液及其制备方法
WO2024206425A1 (fr) 2023-03-31 2024-10-03 Johnson & Johnson Consumer Inc. Compositions liquides thérapeutiques
WO2024206438A1 (fr) 2023-03-31 2024-10-03 Johnson & Johnson Consumer Inc. Compositions de suspension thérapeutiques
US20250110097A1 (en) 2023-09-29 2025-04-03 Kenvue Brands Llc Method for evaluating homogeneity of oral suspensions

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
US3911128A (en) * 1972-02-07 1975-10-07 Sandoz Ag Substituted purines as hypolipidemics
US3852257A (en) * 1973-02-05 1974-12-03 Kelco Co Suspension polymerization in the presence of xanthan gum
US4447454A (en) * 1977-04-01 1984-05-08 The Upjohn Company Analgetic compounds, compositions and process of treatment
US4145440A (en) * 1977-08-18 1979-03-20 The Upjohn Company Liquid suspension of an aluminum salt of ibuprofen
US4329448A (en) * 1979-07-10 1982-05-11 Lever Brothers Company Microbial heteropolysaccharide
CA1167403A (fr) * 1979-07-10 1984-05-15 Unilever Limited Heteropolysaccharides microbiens
JPS5835965B2 (ja) * 1979-07-31 1983-08-05 ライオン株式会社 口腔用組成物
JPS5846483B2 (ja) * 1979-09-20 1983-10-17 ライオン株式会社 口腔用組成物
US4251560A (en) * 1979-08-21 1981-02-17 General Foods Corporation Cream-containing frozen whipped topping composition
US4361580A (en) * 1980-06-20 1982-11-30 The Upjohn Manufacturing Company Aluminum ibuprofen pharmaceutical suspensions
US4346108A (en) * 1981-06-22 1982-08-24 The Upjohn Manufacturing Company M Method for preventing adhesion formation
US4542158A (en) * 1981-12-21 1985-09-17 Merck & Co., Inc. Prodrug esters of diflunisal and related compounds
US4762709A (en) * 1983-09-16 1988-08-09 Pennwalt Corporation Liquid prolonged release pharmaceutical formulations containing ionic constituents
IT1183574B (it) * 1985-05-08 1987-10-22 Eurand Spa Metodo per ottenere una sospensione estemporanea omogenea di microcapsule
US4744986A (en) * 1986-03-07 1988-05-17 Rorer Pharmaceutical Corporation Process for the preparation of a viscosity-stable antacid composition
US4761274A (en) * 1986-03-27 1988-08-02 Warner-Lambert Company Medicament adsorbates of analgesics with complex magnesium aluminum silicate and their preparation
GB8609566D0 (en) * 1986-04-18 1986-05-21 Boots Co Plc Analgesic method
US4684666A (en) * 1986-08-19 1987-08-04 Haas Pharmaceuticals, Inc. Stabilized liquid analgesic compositions
GB8628359D0 (en) * 1986-11-27 1986-12-31 Zyma Sa Galenical formulation
GB8702411D0 (en) * 1987-02-03 1987-03-11 Zyma Sa Swellable pellets
US4788220A (en) * 1987-07-08 1988-11-29 American Home Products Corporation (Del.) Pediatric ibuprofen compositions
US4861797A (en) * 1987-10-15 1989-08-29 Oratech Pharmaceutical Development Corporation Liquid ibuprofen compositions and methods of making them
US4975465A (en) * 1989-03-28 1990-12-04 American Home Products Corporation Orally administrable ibuprofen compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9399013B2 (en) 2006-05-19 2016-07-26 Norbrook Laboratories Limited Stable aqueous suspension

Also Published As

Publication number Publication date
US5621005A (en) 1997-04-15
IE902332A1 (en) 1991-01-16
JP2874967B2 (ja) 1999-03-24
KR910000124A (ko) 1991-01-29
IE902332L (en) 1990-12-28
IL94887A (en) 1994-11-11
ZA905058B (en) 1992-02-26
DE69011766T2 (de) 1994-12-22
KR0161969B1 (ko) 1998-12-01
PT94504B (pt) 1997-02-28
DE69011766D1 (de) 1994-09-29
HK127494A (en) 1994-11-25
GT199000066A (es) 1992-04-09
EP0405930B1 (fr) 1994-08-24
ES2064634T3 (es) 1995-02-01
EP0405930A2 (fr) 1991-01-02
PT94504A (pt) 1991-02-08
AU5792690A (en) 1991-02-07
EP0405930A3 (en) 1991-09-04
GR1002094B (en) 1995-12-28
CA2019863C (fr) 1996-06-04
JPH0363219A (ja) 1991-03-19
NZ234143A (en) 1991-10-25
IE64400B1 (en) 1995-08-09
GR900100481A (el) 1991-11-15
IL94887A0 (en) 1991-04-15
AU635283B2 (en) 1993-03-18
ATE110259T1 (de) 1994-09-15
US5374659A (en) 1994-12-20

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