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CA2016631A1 - Acides aminoalkylphosphiniques substitues - Google Patents

Acides aminoalkylphosphiniques substitues

Info

Publication number
CA2016631A1
CA2016631A1 CA2016631A CA2016631A CA2016631A1 CA 2016631 A1 CA2016631 A1 CA 2016631A1 CA 2016631 A CA2016631 A CA 2016631A CA 2016631 A CA2016631 A CA 2016631A CA 2016631 A1 CA2016631 A1 CA 2016631A1
Authority
CA
Canada
Prior art keywords
denotes
hydrogen
halogen
hydroxy
methyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2016631A
Other languages
English (en)
Other versions
CA2016631C (fr
Inventor
Roger Graham Hall
Ludwig Maier
Wolfgang Frostl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of CA2016631A1 publication Critical patent/CA2016631A1/fr
Application granted granted Critical
Publication of CA2016631C publication Critical patent/CA2016631C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/36—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Luminescent Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
CA002016631A 1989-05-13 1990-05-11 Acides aminoalkylphosphiniques substitues Expired - Lifetime CA2016631C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898911017A GB8911017D0 (en) 1989-05-13 1989-05-13 Substituted aminoalkylphosphinic acids
GB8911017.5 1989-05-13

Publications (2)

Publication Number Publication Date
CA2016631A1 true CA2016631A1 (fr) 1990-11-13
CA2016631C CA2016631C (fr) 2000-08-29

Family

ID=10656689

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002016631A Expired - Lifetime CA2016631C (fr) 1989-05-13 1990-05-11 Acides aminoalkylphosphiniques substitues

Country Status (24)

Country Link
EP (1) EP0399949B1 (fr)
JP (1) JP2930366B2 (fr)
KR (1) KR0159501B1 (fr)
AT (1) ATE121095T1 (fr)
AU (1) AU629335B2 (fr)
CA (1) CA2016631C (fr)
DD (1) DD294265A5 (fr)
DE (1) DE69018514T2 (fr)
DK (1) DK0399949T3 (fr)
ES (1) ES2070303T3 (fr)
FI (1) FI94416C (fr)
GB (1) GB8911017D0 (fr)
GR (1) GR3015770T3 (fr)
HR (1) HRP940178A2 (fr)
HU (1) HU206885B (fr)
IE (1) IE66165B1 (fr)
IL (1) IL94317A (fr)
MX (1) MX20639A (fr)
NO (1) NO176761C (fr)
NZ (1) NZ233647A (fr)
PT (1) PT94014B (fr)
SI (1) SI9010917B (fr)
YU (1) YU91790A (fr)
ZA (1) ZA903611B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812224B2 (en) 1998-07-15 2004-11-02 Jomaa Pharmaka Gmbh Phosphorous organic compounds and their use

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0767174A1 (fr) * 1991-11-21 1997-04-09 Ciba-Geigy Ag Nouveaux acides aminalcanephosphiniques et leurs sels
AU714980B2 (en) 1996-07-24 2000-01-13 Warner-Lambert Company Llc Isobutylgaba and its derivatives for the treatment of pain
GB9906882D0 (en) * 1999-03-25 1999-05-19 Novartis Ag Organic compounds
SE9904508D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
US7319095B2 (en) 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904507D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
AR033779A1 (es) 2001-06-08 2004-01-07 Astrazeneca Ab Compuestos utiles en la enfermedad de reflujo
SE0102055D0 (sv) * 2001-06-08 2001-06-08 Astrazeneca Ab New Compounds
EP2343073A3 (fr) 2003-12-11 2011-10-12 Sepracor Inc. Combinaison de sédatif et modulateur neurotransmetteur et procédés d'amélioration de la qualité du sommeil et de traitement de la dépression
SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
BRPI0620372A2 (pt) 2005-12-23 2011-11-08 Astrazeneca Ab composto, composição farmaceutica, e, uso de um composto
CN101384558A (zh) 2005-12-23 2009-03-11 阿斯利康(瑞典)有限公司 Gaba-b受体调节剂
DE102008056228A1 (de) * 2008-11-06 2010-05-12 Clariant International Limited Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, deren Salze und Ester und ihre Verwendung
DE102008056339A1 (de) * 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von mono-aminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
WO2011113904A1 (fr) 2010-03-17 2011-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Médicaments pour la prévention et le traitement d'une maladie associée à la dégénérescence des cellules ganglionnaires rétiniennes
WO2012050907A2 (fr) 2010-09-28 2012-04-19 The Regents Of The University Of California Agonistes de gaba dans le traitement de troubles associés au syndrome métabolique et combinaisons de gaba dans le traitement ou la prophylaxie du diabète de type i

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3311475C1 (de) * 1983-03-29 1984-08-16 Siemens AG, 1000 Berlin und 8000 München Mikroprogramm-Steuereinrichtung
DE3312165A1 (de) * 1983-04-02 1984-10-04 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von phosphinothricin
GB8728483D0 (en) * 1987-12-04 1988-01-13 Ciba Geigy Ag Chemical compounds
GB8820266D0 (en) * 1988-08-26 1988-09-28 Smith Kline French Lab Compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812224B2 (en) 1998-07-15 2004-11-02 Jomaa Pharmaka Gmbh Phosphorous organic compounds and their use

Also Published As

Publication number Publication date
IE901716L (en) 1990-11-13
HUT53656A (en) 1990-11-28
GR3015770T3 (en) 1995-07-31
HU206885B (en) 1993-01-28
DE69018514T2 (de) 1995-09-21
SI9010917A (en) 1997-06-30
NO176761C (no) 1995-05-24
AU629335B2 (en) 1992-10-01
CA2016631C (fr) 2000-08-29
IL94317A0 (en) 1991-03-10
AU5480990A (en) 1990-11-15
NO902109L (no) 1990-11-14
JPH0395195A (ja) 1991-04-19
HRP940178A2 (en) 1996-08-31
IE66165B1 (en) 1995-12-13
NO902109D0 (no) 1990-05-11
SI9010917B (sl) 1999-10-31
DK0399949T3 (da) 1995-07-03
FI902368A0 (fi) 1990-05-11
DE69018514D1 (de) 1995-05-18
DD294265A5 (de) 1991-09-26
GB8911017D0 (en) 1989-06-28
KR0159501B1 (ko) 1999-01-15
EP0399949A1 (fr) 1990-11-28
EP0399949B1 (fr) 1995-04-12
MX20639A (es) 1993-12-01
HU903012D0 (en) 1990-09-28
FI94416C (fi) 1995-09-11
PT94014A (pt) 1991-01-08
ATE121095T1 (de) 1995-04-15
ES2070303T3 (es) 1995-06-01
KR900018124A (ko) 1990-12-20
NO176761B (no) 1995-02-13
NZ233647A (en) 1992-08-26
YU91790A (sh) 1992-07-20
PT94014B (pt) 1996-12-31
IL94317A (en) 1997-07-13
FI94416B (fi) 1995-05-31
ZA903611B (en) 1991-02-27
JP2930366B2 (ja) 1999-08-03

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKEC Expiry (correction)

Effective date: 20121202