CA2007641A1 - Combinaison d'un inhibiteur de squalene synthetase et d'autres types d'agents reducteurs du cholesterol sanguin et methode pour abaisser le taux de cholesterol sanguin en employant une telle combinaison - Google Patents

Combinaison d'un inhibiteur de squalene synthetase et d'autres types d'agents reducteurs du cholesterol sanguin et methode pour abaisser le taux de cholesterol sanguin en employant une telle combinaison

Info

Publication number: CA2007641A1
Authority: CA; Canada
Prior art keywords: combination; pharmaceutical; squalene synthetase; serum cholesterol; agent
Prior art date: 1989-02-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002007641A

Other languages

English (en)

Inventor

Donald S. Karanewsky

Scott A. Biller

Eric M. Gordon

William A. Scott

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-01

Filing date

1990-01-12

Publication date

1990-08-01

1990-01-12 Application filed by Individual filed Critical Individual

1990-08-01 Publication of CA2007641A1 publication Critical patent/CA2007641A1/fr

Status Abandoned legal-status Critical Current

Links

HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title claims abstract description 49
238000000034 method Methods 0.000 title claims abstract description 15
239000004059 squalene synthase inhibitor Substances 0.000 title abstract description 25
229940123495 Squalene synthetase inhibitor Drugs 0.000 title abstract description 21
239000003638 chemical reducing agent Substances 0.000 title abstract description 3
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239000003112 inhibitor Substances 0.000 claims abstract description 19
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics

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Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA002007641A 1989-02-01 1990-01-12 Combinaison d'un inhibiteur de squalene synthetase et d'autres types d'agents reducteurs du cholesterol sanguin et methode pour abaisser le taux de cholesterol sanguin en employant une telle combinaison Abandoned CA2007641A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US304,534		1981-09-22
US30453489A	1989-02-01	1989-02-01

Publications (1)

Publication Number	Publication Date
CA2007641A1 true CA2007641A1 (fr)	1990-08-01

Family

ID=23176935

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002007641A Abandoned CA2007641A1 (fr)	1989-02-01	1990-01-12	Combinaison d'un inhibiteur de squalene synthetase et d'autres types d'agents reducteurs du cholesterol sanguin et methode pour abaisser le taux de cholesterol sanguin en employant une telle combinaison

Country Status (6)

Country	Link
JP (1)	JPH02235820A (fr)
CA (1)	CA2007641A1 (fr)
DE (1)	DE4002825C2 (fr)
FR (1)	FR2642310B1 (fr)
GB (1)	GB2227663B (fr)
IT (1)	IT1238079B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6264938B1 (en)	1997-11-05	2001-07-24	Geltex Pharmaceuticals, Inc.	Combination therapy for treating hypercholestrolemia

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU3473193A (en) *	1992-01-17	1993-08-03	Procter & Gamble Company, The	Treatment for atherosclerosis
US6203785B1 (en)	1996-12-30	2001-03-20	Geltex Pharmaceuticals, Inc.	Poly(diallylamine)-based bile acid sequestrants
DE10038043B4 (de) *	2000-08-02	2006-09-07	Walter, Michael, Dr.	Phamakologisch wirksame Substanz zur Behandlung kardiovaskulärer Erkrankungen
ATE337326T1 (de)	2002-03-19	2006-09-15	Genzyme Corp	Hemmer des phosphattransports

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5612114B2 (fr) *	1974-06-07	1981-03-18
US4871721A (en) *	1988-01-11	1989-10-03	E. R. Squibb & Sons, Inc.	Phosphorus-containing squalene synthetase inhibitors
CA2003478A1 (fr) *	1988-12-12	1990-06-12	Leonard G. Dennick	Combinaison d'un inhibiteur de hmg coa reductase et d'un autre type d'agent reducteur du cholesterol serique et methode de reduction du cholesterol serique par l'emploi de ladite combinaison

1990
- 1990-01-12 CA CA002007641A patent/CA2007641A1/fr not_active Abandoned
- 1990-01-30 GB GB9002018A patent/GB2227663B/en not_active Expired - Fee Related
- 1990-01-31 FR FR909001123A patent/FR2642310B1/fr not_active Expired - Fee Related
- 1990-01-31 DE DE4002825A patent/DE4002825C2/de not_active Expired - Fee Related
- 1990-02-01 JP JP2023627A patent/JPH02235820A/ja active Pending
- 1990-02-01 IT IT01921990A patent/IT1238079B/it active IP Right Grant

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6264938B1 (en)	1997-11-05	2001-07-24	Geltex Pharmaceuticals, Inc.	Combination therapy for treating hypercholestrolemia
US6365186B1 (en)	1997-11-05	2002-04-02	Geltex Pharmaceuticals, Inc.	Combination therapy for treating hypercholesterolemia
US7638524B2 (en)	1997-11-05	2009-12-29	Genzyme Corporation	Combination therapy for treating hypercholesterolemia

Also Published As

Publication number	Publication date
DE4002825C2 (de)	1998-08-27
GB2227663A (en)	1990-08-08
GB2227663B (en)	1993-03-17
IT9019219A0 (it)	1990-02-01
IT1238079B (it)	1993-07-05
JPH02235820A (ja)	1990-09-18
GB9002018D0 (en)	1990-03-28
IT9019219A1 (it)	1991-08-01
DE4002825A1 (de)	1990-08-02
FR2642310B1 (fr)	1991-10-25
FR2642310A1 (fr)	1990-08-03

Publication	Publication Date	Title
EP0401705A2 (fr)	1990-12-12	Utilisation d'un inhibiteur de l'HMG-CoA réductase et/ou d'un inhibiteur de la squalène-synthétase pour le traitement des maladies athérosclérotiques périphériques
US5593971A (en)	1997-01-14	Method for preventing onset of hypertension employing a cholesterol lowering drug
Kita et al.	1980	Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase
US5260305A (en)	1993-11-09	Combination of pravastatin and nicotinic acid or related acid and method for lowering serum cholesterol using such combination
KR100200467B1 (ko)	1999-06-15	콜레스테롤 저하제 및 ace 억제제로 이루어진 아테롬성 동맥경화증의 예방, 안정화 또는 경감용 조성물
WO1998003069A1 (fr)	1998-01-29	Procede d'abaissement des taux de lipides seriques au moyen d'un inhibiteur de mtp combine a un autre medicament destine a abaisser le cholesterol
EP0455042A1 (fr)	1991-11-06	Association de la pravastatine à un dérivé du "fibric acid" et procédé pour traiter la dyslipémie par application d'une telle association
CA2007643A1 (fr)	1990-08-01	Combinaison d'un inhibiteur de hmg coa et d'un inhibiteur de squalene synthetase et methode pour abaisser le taux de cholesterol sanguin par l'utilisation de cette combinaison
Del Villar et al.	1974	Morphine metabolism
EP0383432B1 (fr)	1993-03-24	Coenzyme Q10 avec inhibiteurs de HMG-COA réductase
CA2003478A1 (fr)	1990-06-12	Combinaison d'un inhibiteur de hmg coa reductase et d'un autre type d'agent reducteur du cholesterol serique et methode de reduction du cholesterol serique par l'emploi de ladite combinaison
CA2007641A1 (fr)	1990-08-01	Combinaison d'un inhibiteur de squalene synthetase et d'autres types d'agents reducteurs du cholesterol sanguin et methode pour abaisser le taux de cholesterol sanguin en employant une telle combinaison
US5470877A (en)	1995-11-28	Uses of perillic acid methyl ester
CA2017692C (fr)	1998-12-29	Derives de carboxamide
US5686494A (en)	1997-11-11	Pharmaceutical preparations for ameliorating epigastric functional disorders
WO1998031225A1 (fr)	1998-07-23	Procede pour inhiber ou traiter la phytosterolemie avec un inhibiteur de mtp
Harwood Jr et al.	1990	Efficacy, tissue distribution and biliary excretion of methyl (3R∗, 5S∗)-(E)-3, 5-dihydroxy-9, 9-diphenyl-6, 8-nonadienoate (CP-83101), A hepatoselective inhibitor of HMG-CoA reductase activity in the rat
US6630502B2 (en)	2003-10-07	Method for preventing, stabilizing or causing regression of atherosclerosis employing a combination of a cholesterol lowering drug and an ace inhibitor
US5093371A (en)	1992-03-03	Naphthyl ketone inhibitors of cholesterol esterase and their use as hypolipidemic and hypocaloric agents
HU193238B (en)	1987-08-28	Process for preparing indanyl-derivatives and pharmaceutical compositions containing such compounds
US3941888A (en)	1976-03-02	Substituted or unsubstituted p-alkanoyl toluenes as hypolipidemics
IL37889A (en)	1974-10-22	Indulamin inhibitors - N - methyl transferase
HK1022105A1 (zh)	2000-09-01	作为3-羟基-3-甲基戊二酰辅酶a(hmg-coa)还原酶抑制剂的柚皮苷和柚苷配基

Legal Events

Date	Code	Title	Description
1996-12-02	EEER	Examination request
2000-06-23	FZDE	Discontinued
2023-05-26	FZDE	Discontinued	Effective date: 20000623