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CA2007336A1 - Test de diagnostic fait au moyen d'anticorps chimeriques - Google Patents

Test de diagnostic fait au moyen d'anticorps chimeriques

Info

Publication number
CA2007336A1
CA2007336A1 CA2007336A CA2007336A CA2007336A1 CA 2007336 A1 CA2007336 A1 CA 2007336A1 CA 2007336 A CA2007336 A CA 2007336A CA 2007336 A CA2007336 A CA 2007336A CA 2007336 A1 CA2007336 A1 CA 2007336A1
Authority
CA
Canada
Prior art keywords
antibody
binding
solid phase
chimeric antibodies
diagnostic test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2007336A
Other languages
English (en)
Other versions
CA2007336C (fr
Inventor
Brigitte Kaluza
Helmut Lenz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2007336A1 publication Critical patent/CA2007336A1/fr
Application granted granted Critical
Publication of CA2007336C publication Critical patent/CA2007336C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002007336A 1989-01-10 1990-01-08 Test de diagnostic fait au moyen d'anticorps chimeriques Expired - Lifetime CA2007336C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3900534A DE3900534A1 (de) 1989-01-10 1989-01-10 Diagnostischer nachweis unter verwendung von chimaeren antikoerpern
DEP3900534.8 1989-01-10

Publications (2)

Publication Number Publication Date
CA2007336A1 true CA2007336A1 (fr) 1990-07-10
CA2007336C CA2007336C (fr) 2001-01-02

Family

ID=6371816

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002007336A Expired - Lifetime CA2007336C (fr) 1989-01-10 1990-01-08 Test de diagnostic fait au moyen d'anticorps chimeriques

Country Status (9)

Country Link
US (1) US5614367A (fr)
EP (1) EP0378175B1 (fr)
JP (1) JP2787098B2 (fr)
AT (1) ATE123340T1 (fr)
AU (1) AU629886B2 (fr)
CA (1) CA2007336C (fr)
DE (2) DE3900534A1 (fr)
DK (1) DK0378175T3 (fr)
ZA (1) ZA90136B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614367A (en) * 1989-01-10 1997-03-25 Boehringer Mannheim Gmbh Diagnostic test using chimeric antibodies
US6403769B1 (en) 1994-02-01 2002-06-11 The United States Of America As Represented By The Department Of Health And Human Services Fusion proteins that include antibody and nonantibody portions

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5579463A (en) * 1990-03-30 1996-11-26 Anritsu Corporation Waveform display apparatus of frequency sweep type for facilitating display of a high definition waveform
US5434954A (en) * 1990-03-30 1995-07-18 Anritsu Corporation Waveform display apparatus for easily realizing high-definition waveform observation
DE4033120A1 (de) * 1990-10-18 1992-04-23 Boehringer Mannheim Gmbh Verfahren zur herstellung von chimaeren antikoerpern
US5617523A (en) * 1990-11-30 1997-04-01 Anritsu Corporation Waveform display apparatus for easily realizing high-definition waveform observation
WO1998033914A1 (fr) * 1997-01-31 1998-08-06 University Of Rochester Proteines de fusion d'anticorps chimeriques utilisees pour induire et stimuler une reponse immunitaire antitumorale
US6087088A (en) * 1997-01-31 2000-07-11 Bayer Corporation Binding assays using more than one label for determining analyte in the presence of interfering factors
DE19739218A1 (de) * 1997-09-08 1999-03-11 Boehringer Mannheim Gmbh Aufreinigung von Substanzen aus einer biologischen Probe
ATE225511T1 (de) * 1997-12-11 2002-10-15 Roche Diagnostics Gmbh Entstörung von diagnostischen verfahren durch peptide aus d-aminosäuren
DE19828466A1 (de) 1998-06-26 1999-12-30 Roche Diagnostics Gmbh Entstörung von Immunoassays durch Substanzen, die aus den Framework-Regionen von Antikörpern abgeleitet sind
US6492497B1 (en) * 1999-04-30 2002-12-10 Cambridge Antibody Technology Limited Specific binding members for TGFbeta1
US6680209B1 (en) * 1999-12-06 2004-01-20 Biosite, Incorporated Human antibodies as diagnostic reagents
DE19962583A1 (de) * 1999-12-23 2001-06-28 Mueller Hermelink Hans Konrad Antikörper gegen Plasmazellen
EP1258729A3 (fr) * 2001-05-18 2004-01-02 Takeda Chemical Industries, Ltd. Une méthode pour la sélection d'un anticorps, une hybridome, un anticorps monoclonal et son utilisation
US20040018556A1 (en) * 2002-07-29 2004-01-29 Cantor Thomas L. Reagent and method for determination of a substance using an immunoaggregator
WO2007011698A2 (fr) * 2005-07-15 2007-01-25 Siemens Medical Solutions Diagnostics Conjugues d'anticorps humanises et procedes correspondants, essais biologiques, reactifs et trousses
EP2220121B1 (fr) * 2007-11-12 2015-08-19 U3 Pharma GmbH Anticorps anti-axl
KR20120035145A (ko) 2009-05-11 2012-04-13 우드라이 파마 게엠베하 인간화 ａｘｌ 항체
CN111492246A (zh) * 2017-09-20 2020-08-04 梅尔莎纳医疗公司 用于预测对napi2b靶向疗法的响应的组合物和方法
CA3109790A1 (fr) 2018-08-17 2020-02-20 Mersana Therapeutics, Inc. Conjugues anticorps-medicament polymere ciblant napi2b et leurs procedes d'utilisation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6147500A (ja) * 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
GB8422238D0 (en) * 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS62201598A (ja) * 1986-02-28 1987-09-05 Teijin Ltd マウス−ヒトキメラ抗体ｈ鎖、それをコ−ドするキメラｄｎａ配列、プラスミドおよび細胞
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
IL84285A (en) * 1986-10-27 1993-03-15 Int Genetic Engineering Chimeric antibody with specificity to human tumor antigen
IL85035A0 (en) * 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
AU625613B2 (en) * 1988-01-05 1992-07-16 Novartis Ag Novel chimeric antibodies
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
DE3900534A1 (de) * 1989-01-10 1990-07-12 Boehringer Mannheim Gmbh Diagnostischer nachweis unter verwendung von chimaeren antikoerpern
AU645981B2 (en) * 1990-04-25 1994-02-03 City Of Hope Removal of human anti-murine and heterophilic antibody interference in double antibody EIA assays

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614367A (en) * 1989-01-10 1997-03-25 Boehringer Mannheim Gmbh Diagnostic test using chimeric antibodies
US6403769B1 (en) 1994-02-01 2002-06-11 The United States Of America As Represented By The Department Of Health And Human Services Fusion proteins that include antibody and nonantibody portions

Also Published As

Publication number Publication date
DE3900534A1 (de) 1990-07-12
ZA90136B (en) 1990-10-31
EP0378175A2 (fr) 1990-07-18
EP0378175B1 (fr) 1995-05-31
AU4768490A (en) 1990-07-19
CA2007336C (fr) 2001-01-02
JPH02231567A (ja) 1990-09-13
DE59009163D1 (de) 1995-07-06
US5614367A (en) 1997-03-25
DK0378175T3 (da) 1995-10-02
ATE123340T1 (de) 1995-06-15
AU629886B2 (en) 1992-10-15
JP2787098B2 (ja) 1998-08-13
EP0378175A3 (fr) 1991-04-03

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