CA2093133A1 - Surfactant synthetique du poumon - Google Patents
Surfactant synthetique du poumonInfo
- Publication number
- CA2093133A1 CA2093133A1 CA2093133A CA2093133A CA2093133A1 CA 2093133 A1 CA2093133 A1 CA 2093133A1 CA 2093133 A CA2093133 A CA 2093133A CA 2093133 A CA2093133 A CA 2093133A CA 2093133 A1 CA2093133 A1 CA 2093133A1
- Authority
- CA
- Canada
- Prior art keywords
- lung surfactant
- temperature
- composition
- phosphatidylcholine
- lamellar form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000596 artificial lung surfactant Substances 0.000 title abstract 3
- 239000003580 lung surfactant Substances 0.000 abstract 5
- 229940066294 lung surfactant Drugs 0.000 abstract 5
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 abstract 3
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 abstract 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- MWRBNPKJOOWZPW-CLFAGFIQSA-N dioleoyl phosphatidylethanolamine Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC MWRBNPKJOOWZPW-CLFAGFIQSA-N 0.000 abstract 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 abstract 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 abstract 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 abstract 1
- 230000036760 body temperature Effects 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000000151 deposition Methods 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000002356 single layer Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne une composition d'un agent tensio-actif synthétique pour les poumons ainsi qu'un procédé permettant de déposer une monocouche d'un agent tensio-actif à base de phosphatidylcholine sur les alvéoles des poumons d'un mammifère. La composition comprend un agent tensio-actif à base de phosphatidylcholine, une phosphatidyléthanolamine, et du cholestérol dans des proportions telles que la composition se présente sous forme lamellaire à une température égale ou inférieure à une première température et dans une forme non lamellaire à une seconde température qui est supérieure à la première température. Un agent tensio-actif à base de phosphatidylcholine préféré pour le traitement des poumons est le dipalmitoyl phosphatidylcholine (DPPC), qui est connu comme étant le constituant lipide principal de l'agent tensio-actif naturel des poumons de mammifère, et une phosphatidyléthanolamine préférée est la dioléoyle phosphatidyléthanolamine (DOPE). Dans des modes particuliers de réalisation, la composition se présente sous forme lamellaire approximativement à température ambiante (25 C), et sous forme non lamellaire à une température de l'ordre de 30 à 37 C, ce qui est une température égale ou inférieure à la température normale du corps (37 C). La composition peut également contenir un ou plusieurs peptides thérapeutiques ou autres agents pharmaceutiques. L'agent tensio-actif synthétique pour le traitement des poumons peut être utilisé pour traiter un mammifère présentant un syndrome de gènes respiratoires dus à une insuffisance de l'agent tensio-actif naturel des poumons.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59949390A | 1990-10-17 | 1990-10-17 | |
| US07/599,493 | 1990-10-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2093133A1 true CA2093133A1 (fr) | 1992-04-18 |
| CA2093133C CA2093133C (fr) | 1999-03-30 |
Family
ID=24399851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002093133A Expired - Fee Related CA2093133C (fr) | 1990-10-17 | 1991-10-17 | Surfactant synthetique du poumon |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0553272B1 (fr) |
| JP (1) | JP3171445B2 (fr) |
| KR (1) | KR0181309B1 (fr) |
| AT (1) | ATE192930T1 (fr) |
| AU (1) | AU650303B2 (fr) |
| CA (1) | CA2093133C (fr) |
| DE (1) | DE69132211T2 (fr) |
| DK (1) | DK0553272T3 (fr) |
| ES (1) | ES2146580T3 (fr) |
| GR (1) | GR3034211T3 (fr) |
| WO (1) | WO1992006703A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9120005D0 (en) * | 1991-09-19 | 1991-11-06 | Wellcome Found | Method of administering phospholipid dispersions |
| WO1997026863A1 (fr) | 1996-01-24 | 1997-07-31 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Procede pour fabriquer des preparations de surfactants pulmonaires en poudre |
| WO1997035559A2 (fr) * | 1996-03-27 | 1997-10-02 | Ortho Pharmaceutical Corporation | Preparation de liposomes et de complexes lipoproteiques par injection d'ethanol et evaporation en couche mince |
| CA2477592A1 (fr) * | 2002-03-18 | 2003-09-25 | Yamanouchi Pharmaceutical Co., Ltd. | Compositions medicales en poudre pour inhalation et procede de production de celles-ci |
| CN103052380B (zh) | 2010-08-23 | 2015-11-25 | 塔科达有限责任公司 | 包含治疗活性物质的湿润颗粒 |
| AU2015226287B2 (en) | 2014-03-05 | 2019-01-31 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Humidifier for humidifying an aerosol |
| US10737088B2 (en) | 2014-03-05 | 2020-08-11 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Device for providing a constant amount of aerosol |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5795920A (en) * | 1980-12-04 | 1982-06-15 | Teijin Ltd | Remedy for respiratory disease |
| US4915951A (en) * | 1987-12-03 | 1990-04-10 | California Institute Of Technology | Cryoprotective reagent |
-
1991
- 1991-10-17 ES ES91920210T patent/ES2146580T3/es not_active Expired - Lifetime
- 1991-10-17 AT AT91920210T patent/ATE192930T1/de not_active IP Right Cessation
- 1991-10-17 KR KR1019930701000A patent/KR0181309B1/ko not_active Expired - Fee Related
- 1991-10-17 CA CA002093133A patent/CA2093133C/fr not_active Expired - Fee Related
- 1991-10-17 AU AU89291/91A patent/AU650303B2/en not_active Ceased
- 1991-10-17 JP JP50075992A patent/JP3171445B2/ja not_active Expired - Fee Related
- 1991-10-17 DK DK91920210T patent/DK0553272T3/da active
- 1991-10-17 DE DE69132211T patent/DE69132211T2/de not_active Expired - Fee Related
- 1991-10-17 EP EP91920210A patent/EP0553272B1/fr not_active Expired - Lifetime
- 1991-10-17 WO PCT/US1991/007746 patent/WO1992006703A1/fr not_active Ceased
-
2000
- 2000-08-17 GR GR20000401896T patent/GR3034211T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0553272B1 (fr) | 2000-05-17 |
| AU8929191A (en) | 1992-05-20 |
| DE69132211D1 (de) | 2000-06-21 |
| KR0181309B1 (ko) | 1999-03-20 |
| EP0553272A4 (en) | 1994-09-07 |
| EP0553272A1 (fr) | 1993-08-04 |
| DK0553272T3 (da) | 2000-09-04 |
| DE69132211T2 (de) | 2000-11-23 |
| CA2093133C (fr) | 1999-03-30 |
| JPH06502427A (ja) | 1994-03-17 |
| AU650303B2 (en) | 1994-06-16 |
| WO1992006703A1 (fr) | 1992-04-30 |
| GR3034211T3 (en) | 2000-12-29 |
| ES2146580T3 (es) | 2000-08-16 |
| ATE192930T1 (de) | 2000-06-15 |
| JP3171445B2 (ja) | 2001-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed | ||
| MKLA | Lapsed |
Effective date: 20071017 |