CA2087171A1 - Methode de depistage du cancer par mesure de la peroxidation des lipides par rmn - Google Patents
Methode de depistage du cancer par mesure de la peroxidation des lipides par rmnInfo
- Publication number
- CA2087171A1 CA2087171A1 CA002087171A CA2087171A CA2087171A1 CA 2087171 A1 CA2087171 A1 CA 2087171A1 CA 002087171 A CA002087171 A CA 002087171A CA 2087171 A CA2087171 A CA 2087171A CA 2087171 A1 CA2087171 A1 CA 2087171A1
- Authority
- CA
- Canada
- Prior art keywords
- spectrum
- category
- cancer
- abnormal
- resonance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 119
- 201000011510 cancer Diseases 0.000 title claims abstract description 109
- 238000000034 method Methods 0.000 title claims abstract description 96
- 230000003859 lipid peroxidation Effects 0.000 title description 2
- 238000001228 spectrum Methods 0.000 claims abstract description 80
- 238000005481 NMR spectroscopy Methods 0.000 claims abstract description 72
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 52
- 210000001124 body fluid Anatomy 0.000 claims abstract description 25
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 claims abstract description 24
- 150000003626 triacylglycerols Chemical class 0.000 claims abstract description 19
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims abstract description 15
- 230000002159 abnormal effect Effects 0.000 claims description 61
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 claims description 46
- 210000002381 plasma Anatomy 0.000 claims description 36
- 102000004895 Lipoproteins Human genes 0.000 claims description 34
- 108090001030 Lipoproteins Proteins 0.000 claims description 34
- 239000002131 composite material Substances 0.000 claims description 33
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 29
- 150000002632 lipids Chemical class 0.000 claims description 23
- 238000005160 1H NMR spectroscopy Methods 0.000 claims description 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
- 210000004369 blood Anatomy 0.000 claims description 12
- 239000008280 blood Substances 0.000 claims description 12
- 210000002966 serum Anatomy 0.000 claims description 7
- 210000001185 bone marrow Anatomy 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 125000000746 allylic group Chemical group 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- 239000012503 blood component Substances 0.000 claims 16
- 239000000306 component Substances 0.000 claims 8
- 238000001514 detection method Methods 0.000 abstract description 8
- 230000001629 suppression Effects 0.000 abstract description 4
- 238000004611 spectroscopical analysis Methods 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 11
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 10
- 235000020778 linoleic acid Nutrition 0.000 description 10
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 8
- 230000036210 malignancy Effects 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 208000006575 hypertriglyceridemia Diseases 0.000 description 5
- 230000007423 decrease Effects 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 3
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 3
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 3
- 235000021281 monounsaturated fatty acids Nutrition 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000000873 masking effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 102220493949 26S proteasome complex subunit SEM1_U13S_mutation Human genes 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 description 1
- 241000543381 Cliftonia monophylla Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 206010014486 Elevated triglycerides Diseases 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000252067 Megalops atlanticus Species 0.000 description 1
- 241001163743 Perlodes Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 1
- 150000002889 oleic acids Chemical class 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55752990A | 1990-07-24 | 1990-07-24 | |
| US557,529 | 1990-07-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2087171A1 true CA2087171A1 (fr) | 1992-01-25 |
Family
ID=24225791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002087171A Abandoned CA2087171A1 (fr) | 1990-07-24 | 1991-07-23 | Methode de depistage du cancer par mesure de la peroxidation des lipides par rmn |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPH05509162A (fr) |
| AU (1) | AU8413991A (fr) |
| CA (1) | CA2087171A1 (fr) |
| FI (1) | FI930177A0 (fr) |
| IE (1) | IE912581A1 (fr) |
| NZ (1) | NZ239080A (fr) |
| PT (1) | PT98433B (fr) |
| WO (1) | WO1992001419A1 (fr) |
| ZA (1) | ZA915771B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01006287A (es) | 1999-10-21 | 2002-04-17 | Nidek Kk | Aparato para determinar una cantidad de ablacion de cornea y aparato quirurgico para una cornea.,. |
| AU2006207953B2 (en) | 2005-01-28 | 2012-08-23 | The Regents Of The University Of California | Systems and methods using nuclear magnetic resonance (NMR) spectroscopy to evaluate pain and degenerative properties of tissue |
| US8761860B2 (en) | 2009-10-14 | 2014-06-24 | Nocimed, Llc | MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs |
| US8825131B2 (en) | 2009-10-14 | 2014-09-02 | Nocimed, Llc | MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs |
| US9280718B2 (en) | 2010-11-24 | 2016-03-08 | Nocimed, Llc | Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy |
| US8965094B2 (en) | 2012-04-14 | 2015-02-24 | Nocimed, Llc | Magnetic resonance spectroscopy pulse sequence, acquisition, and processing system and method |
| AU2017282665B2 (en) | 2016-06-19 | 2022-05-19 | Aclarion, Inc. | Magnetic resonance spectroscopy system and method for diagnosing pain or infection associated with propionic acid |
-
1991
- 1991-07-23 NZ NZ239080A patent/NZ239080A/en unknown
- 1991-07-23 CA CA002087171A patent/CA2087171A1/fr not_active Abandoned
- 1991-07-23 IE IE258191A patent/IE912581A1/en unknown
- 1991-07-23 AU AU84139/91A patent/AU8413991A/en not_active Abandoned
- 1991-07-23 WO PCT/US1991/005182 patent/WO1992001419A1/fr not_active Ceased
- 1991-07-23 JP JP3513741A patent/JPH05509162A/ja active Pending
- 1991-07-23 ZA ZA915771A patent/ZA915771B/xx unknown
- 1991-07-24 PT PT98433A patent/PT98433B/pt not_active IP Right Cessation
-
1993
- 1993-01-15 FI FI930177A patent/FI930177A0/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FI930177A7 (fi) | 1993-01-15 |
| AU8413991A (en) | 1992-02-18 |
| JPH05509162A (ja) | 1993-12-16 |
| ZA915771B (en) | 1992-04-29 |
| NZ239080A (en) | 1993-10-26 |
| IE912581A1 (en) | 1992-01-29 |
| PT98433B (pt) | 1999-01-29 |
| FI930177A0 (fi) | 1993-01-15 |
| WO1992001419A1 (fr) | 1992-02-06 |
| PT98433A (pt) | 1992-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |