CA2073781A1 - Procede de formation de revetements bioactifs composes sur les implants - Google Patents
Procede de formation de revetements bioactifs composes sur les implantsInfo
- Publication number
- CA2073781A1 CA2073781A1 CA 2073781 CA2073781A CA2073781A1 CA 2073781 A1 CA2073781 A1 CA 2073781A1 CA 2073781 CA2073781 CA 2073781 CA 2073781 A CA2073781 A CA 2073781A CA 2073781 A1 CA2073781 A1 CA 2073781A1
- Authority
- CA
- Canada
- Prior art keywords
- electrolyte
- implantable device
- calcium
- calcium phosphate
- hydroxyapatite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000576 coating method Methods 0.000 title claims abstract description 53
- 238000000034 method Methods 0.000 title claims abstract description 52
- 239000002131 composite material Substances 0.000 title claims abstract description 26
- 230000000975 bioactive effect Effects 0.000 title claims abstract description 11
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 40
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 30
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 30
- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 30
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 24
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 19
- 239000000758 substrate Substances 0.000 claims abstract description 19
- 239000011248 coating agent Substances 0.000 claims description 43
- 239000003792 electrolyte Substances 0.000 claims description 39
- 229910052719 titanium Inorganic materials 0.000 claims description 18
- 239000010936 titanium Substances 0.000 claims description 18
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 17
- 210000000988 bone and bone Anatomy 0.000 claims description 12
- 239000011575 calcium Substances 0.000 claims description 12
- 150000002500 ions Chemical class 0.000 claims description 10
- 229910052586 apatite Inorganic materials 0.000 claims description 9
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 230000002950 deficient Effects 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 5
- 229910001424 calcium ion Inorganic materials 0.000 claims description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 claims description 4
- 108010035532 Collagen Proteins 0.000 claims description 4
- 229910045601 alloy Inorganic materials 0.000 claims description 4
- 239000000956 alloy Substances 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 4
- -1 calcium phosphate compound Chemical class 0.000 claims description 4
- 229920001436 collagen Polymers 0.000 claims description 4
- 230000007797 corrosion Effects 0.000 claims description 4
- 238000005260 corrosion Methods 0.000 claims description 4
- 229910044991 metal oxide Inorganic materials 0.000 claims description 4
- 150000004706 metal oxides Chemical class 0.000 claims description 4
- 230000000921 morphogenic effect Effects 0.000 claims description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 4
- 239000012670 alkaline solution Substances 0.000 claims description 3
- 239000003242 anti bacterial agent Substances 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000004070 electrodeposition Methods 0.000 claims description 3
- 229940088623 biologically active substance Drugs 0.000 claims description 2
- 238000005868 electrolysis reaction Methods 0.000 claims description 2
- 239000000080 wetting agent Substances 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 238000005245 sintering Methods 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000007943 implant Substances 0.000 description 9
- 238000001228 spectrum Methods 0.000 description 9
- 239000000243 solution Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229910002804 graphite Inorganic materials 0.000 description 3
- 239000010439 graphite Substances 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000002441 X-ray diffraction Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
- 239000004068 calcium phosphate ceramic Substances 0.000 description 2
- 238000005524 ceramic coating Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000010335 hydrothermal treatment Methods 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 229910052720 vanadium Inorganic materials 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 229910020630 Co Ni Inorganic materials 0.000 description 1
- 229910002440 Co–Ni Inorganic materials 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 239000003522 acrylic cement Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 238000005275 alloying Methods 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000004394 hip joint Anatomy 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000005488 sandblasting Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D9/00—Electrolytic coating other than with metals
- C25D9/04—Electrolytic coating other than with metals with inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2073781 CA2073781A1 (fr) | 1992-07-13 | 1992-07-13 | Procede de formation de revetements bioactifs composes sur les implants |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2073781 CA2073781A1 (fr) | 1992-07-13 | 1992-07-13 | Procede de formation de revetements bioactifs composes sur les implants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2073781A1 true CA2073781A1 (fr) | 1994-01-14 |
Family
ID=4150150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2073781 Abandoned CA2073781A1 (fr) | 1992-07-13 | 1992-07-13 | Procede de formation de revetements bioactifs composes sur les implants |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2073781A1 (fr) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996007438A1 (fr) * | 1994-09-07 | 1996-03-14 | Dot Dünnschicht- Und Oberflächentechnologie Gmbh | Procede d'electrodeposition de couches d'hydroxyapatite |
| WO1996024391A1 (fr) * | 1995-02-10 | 1996-08-15 | Technische Universität Dresden | Procede pour produire un revetement a gradients de phases de phosphate de calcium et de phases d'oxyde metallique sur des implants metalliques |
| DE102004022768A1 (de) * | 2004-05-05 | 2005-12-08 | Heraeus Kulzer Gmbh | Medizinische Implantate mit glaskeramikartiger Multielement-Oberflächenschicht |
| EP1618904A1 (fr) * | 2004-06-30 | 2006-01-25 | Friadent GmbH | Implant avec une surface biofonctionnalisée et procédé pour sa fabrication |
| WO2006007730A1 (fr) * | 2004-07-21 | 2006-01-26 | The University Of British Columbia | Implants osseux et procedes d'enrobage de ces implants |
| WO2008025122A1 (fr) * | 2006-08-30 | 2008-03-06 | The University Of British Columbia | Revêtements composites biocéramiques et procédés de fabrication |
| WO2008146113A3 (fr) * | 2007-05-28 | 2009-02-05 | Fin Ceramica Faenza Spa | Procédé pour le revêtement d'une surface d'un élément métallique pour augmenter l'ostéointégration de celui-ci et dispositif prothétique comprenant ledit élément |
| ITMI20102071A1 (it) * | 2010-11-09 | 2012-05-10 | Chemical Ct S R L | Elettrodeposizione di idrossiapatite nanometrica su impianti protesici e processo elettrolitico per la sua realizzazione |
| EP3072534A1 (fr) * | 2013-03-11 | 2016-09-28 | DOT GmbH | Procédé de fabrication d'un implant fonctionnalisé et implant fonctionnalisé |
-
1992
- 1992-07-13 CA CA 2073781 patent/CA2073781A1/fr not_active Abandoned
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996007438A1 (fr) * | 1994-09-07 | 1996-03-14 | Dot Dünnschicht- Und Oberflächentechnologie Gmbh | Procede d'electrodeposition de couches d'hydroxyapatite |
| US5759376A (en) * | 1994-09-07 | 1998-06-02 | Dot Dunnschicht- Und Oberflaechen-Technologie Gmbh | Method for the electrodeposition of hydroxyapatite layers |
| WO1996024391A1 (fr) * | 1995-02-10 | 1996-08-15 | Technische Universität Dresden | Procede pour produire un revetement a gradients de phases de phosphate de calcium et de phases d'oxyde metallique sur des implants metalliques |
| US5723038A (en) * | 1995-02-10 | 1998-03-03 | Jurgen Hofinger | Process for producing a gradient coating made of calcium phosphate phases and metal oxide phase on metallic implants |
| DE102004022768A1 (de) * | 2004-05-05 | 2005-12-08 | Heraeus Kulzer Gmbh | Medizinische Implantate mit glaskeramikartiger Multielement-Oberflächenschicht |
| EP1618904A1 (fr) * | 2004-06-30 | 2006-01-25 | Friadent GmbH | Implant avec une surface biofonctionnalisée et procédé pour sa fabrication |
| WO2006007730A1 (fr) * | 2004-07-21 | 2006-01-26 | The University Of British Columbia | Implants osseux et procedes d'enrobage de ces implants |
| WO2008025122A1 (fr) * | 2006-08-30 | 2008-03-06 | The University Of British Columbia | Revêtements composites biocéramiques et procédés de fabrication |
| WO2008146113A3 (fr) * | 2007-05-28 | 2009-02-05 | Fin Ceramica Faenza Spa | Procédé pour le revêtement d'une surface d'un élément métallique pour augmenter l'ostéointégration de celui-ci et dispositif prothétique comprenant ledit élément |
| ITMI20102071A1 (it) * | 2010-11-09 | 2012-05-10 | Chemical Ct S R L | Elettrodeposizione di idrossiapatite nanometrica su impianti protesici e processo elettrolitico per la sua realizzazione |
| EP3072534A1 (fr) * | 2013-03-11 | 2016-09-28 | DOT GmbH | Procédé de fabrication d'un implant fonctionnalisé et implant fonctionnalisé |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |