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CA2069910A1 - Antagonistes du recepteur muscarinique - Google Patents

Antagonistes du recepteur muscarinique

Info

Publication number
CA2069910A1
CA2069910A1 CA2069910A CA2069910A CA2069910A1 CA 2069910 A1 CA2069910 A1 CA 2069910A1 CA 2069910 A CA2069910 A CA 2069910A CA 2069910 A CA2069910 A CA 2069910A CA 2069910 A1 CA2069910 A1 CA 2069910A1
Authority
CA
Canada
Prior art keywords
alkyl
receptor antagonists
muscarinic receptor
formula
nconr6r7
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2069910A
Other languages
English (en)
Other versions
CA2069910C (fr
Inventor
Peter Edward Cross
Alexander Roderick Mackenzie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2069910A1 publication Critical patent/CA2069910A1/fr
Application granted granted Critical
Publication of CA2069910C publication Critical patent/CA2069910C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002069910A 1989-12-12 1990-11-28 Antagonistes du recepteur muscarinique Expired - Fee Related CA2069910C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8928042.4 1989-12-12
GB898928042A GB8928042D0 (en) 1989-12-12 1989-12-12 Muscarinic receptor antagonists

Publications (2)

Publication Number Publication Date
CA2069910A1 true CA2069910A1 (fr) 1991-06-13
CA2069910C CA2069910C (fr) 1996-11-12

Family

ID=10667813

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002069910A Expired - Fee Related CA2069910C (fr) 1989-12-12 1990-11-28 Antagonistes du recepteur muscarinique

Country Status (14)

Country Link
US (1) US5340831A (fr)
EP (1) EP0505376B1 (fr)
JP (1) JPH0678303B2 (fr)
AT (1) ATE115126T1 (fr)
CA (1) CA2069910C (fr)
DE (1) DE69014901T2 (fr)
DK (1) DK0505376T3 (fr)
ES (1) ES2064771T3 (fr)
FI (1) FI95027C (fr)
GB (1) GB8928042D0 (fr)
GR (1) GR3014907T3 (fr)
IE (1) IE64205B1 (fr)
PT (1) PT96144A (fr)
WO (1) WO1991009013A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5569664A (en) * 1995-02-16 1996-10-29 Fmc Corporation Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl) methyl]pi
US6017931A (en) * 1994-03-01 2000-01-25 Fmc Corporation Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5639763A (en) * 1994-03-01 1997-06-17 Fmc Corporation Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
JP4167302B2 (ja) * 1996-12-02 2008-10-15 杏林製薬株式会社 新規ｎ―置換ピロリジン誘導体及びその製造法
US6693202B1 (en) * 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
EP1546099B1 (fr) 2002-07-08 2008-12-31 Ranbaxy Laboratories Limited Derives d'azabicyclo 3.1.0 hexanes 3,6-disubstitues utiles comme antagonistes des recepteurs muscariniques
ATE396969T1 (de) 2002-07-31 2008-06-15 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo (3.1.0)hexanderivate, die sich als muscarinrezeptorantagonisten eignen
AU2002321711A1 (en) 2002-08-09 2004-02-25 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives useful as muscarinic receptor antagonist
DE60231341D1 (de) 2002-08-23 2009-04-09 Ranbaxy Lab Ltd Fluor- und sulfonylaminohaltige, 3,6-disubstituierptorantagonisten
TWI295669B (en) * 2002-10-30 2008-04-11 Theravance Inc Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
US7232835B2 (en) 2002-12-10 2007-06-19 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo derivatives as muscarinic receptor antagonists
DE60225195T2 (de) 2002-12-23 2009-02-26 Ranbaxy Laboratories, Ltd. Flavaxat-derivate als muscarin-rezeptor antagonisten
WO2004056767A1 (fr) 2002-12-23 2004-07-08 Ranbaxy Laboratories Limited Derives de 1-substitues-3-pyrrolidines comme antagonistes de recepteurs muscariniques
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
US7317102B2 (en) 2003-04-01 2008-01-08 Theravance, Inc. Diarylmethyl and related compounds
US7517905B2 (en) 2003-04-09 2009-04-14 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
CA2521788A1 (fr) 2003-04-10 2004-10-21 Ranbaxy Laboratories Limited Derives d'azabicyclo hexanes substitues en tant qu'antagonistes des recepteurs muscariniques
AU2003223010A1 (en) 2003-04-10 2004-11-01 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2004089900A1 (fr) 2003-04-11 2004-10-21 Ranbaxy Laboratories Limited Derives azabicyclo utiles comme antagonistes du recepteur muscarinique
TW200510298A (en) 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
EP1644356A1 (fr) 2003-07-11 2006-04-12 Theravance, Inc. Composes de 4-amino-1-benzylpiperidine substitues
US7071224B2 (en) * 2004-03-11 2006-07-04 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
US7250414B2 (en) * 2004-03-11 2007-07-31 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
EP1926709A4 (fr) 2005-08-25 2009-06-24 Rstech Corp Procédé de synthèse d'un composé chiral de type 3-hydroxypyrrolidine et de dérivés dudit composé de pureté optique élevée
AU2006305619A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
WO2007076159A2 (fr) * 2005-12-27 2007-07-05 Teva Pharmaceutical Industries Ltd. Bromhydrate de darifenacine pur sensiblement exempt de darifenacine oxydee, sels de celui-ci, et procedes de preparation de ceux-ci
ES2554646T3 (es) * 2007-02-23 2015-12-22 Theravance Biopharma R&D Ip, Llc Compuestos de difenilmetilo de amonio cuaternario, de utilidad como antagonistas de receptores muscarínicos
JP2010525058A (ja) 2007-04-24 2010-07-22 セラヴァンス， インコーポレーテッド ムスカリン受容体アンタゴニストとして有用な第４級アンモニウム化合物
AU2009318789B2 (en) 2008-11-24 2014-05-29 Council Of Scientific & Industrial Research A Process For The Preparation Of Optically Active N-Benzyl-3-Hydroxypyrrolidines

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL76583A (en) * 1984-10-19 1988-08-31 Robins Co Inc A H 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them
EP0228893A3 (fr) * 1985-12-20 1990-01-03 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Amines arylalkyl-hétérocycliques N-substitués par un groupe aryloxyalkyl dans le traitement des allergies
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
IN163948B (fr) * 1986-01-17 1988-12-10 Robins Co Inc A H
US5233053A (en) * 1989-03-17 1993-08-03 Pfizer Inc. Pyrrolidine derivatives
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents

Also Published As

Publication number Publication date
FI922345A0 (fi) 1992-05-22
US5340831A (en) 1994-08-23
IE64205B1 (en) 1995-07-12
EP0505376A1 (fr) 1992-09-30
PT96144A (pt) 1991-09-30
DE69014901D1 (de) 1995-01-19
JPH0678303B2 (ja) 1994-10-05
WO1991009013A1 (fr) 1991-06-27
ES2064771T3 (es) 1995-02-01
ATE115126T1 (de) 1994-12-15
DE69014901T2 (de) 1995-04-27
DK0505376T3 (da) 1995-02-13
GR3014907T3 (en) 1995-05-31
FI922345L (fi) 1992-05-22
JPH04505927A (ja) 1992-10-15
CA2069910C (fr) 1996-11-12
EP0505376B1 (fr) 1994-12-07
GB8928042D0 (en) 1990-02-14
FI95027C (fi) 1995-12-11
FI95027B (fi) 1995-08-31
IE904463A1 (en) 1991-06-19

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed