CA2065044A1 - Compositions stabilisees et a odeur masquee pour le traitement des tissus keratinoides, des maladies de la peau et pour favoriser la guerison des plaies - Google Patents

Compositions stabilisees et a odeur masquee pour le traitement des tissus keratinoides, des maladies de la peau et pour favoriser la guerison des plaies

Info

Publication number: CA2065044A1
Authority: CA; Canada
Prior art keywords: composition according; agents; weight; protein; compositions
Prior art date: 1989-08-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002065044A

Other languages

English (en)

Inventor

John Rothman

Philip Band

Jack Oceta

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

John Morris Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-18

Filing date

1990-08-17

Publication date

1991-02-19

1990-08-17 Application filed by John Morris Co Inc filed Critical John Morris Co Inc

1991-02-19 Publication of CA2065044A1 publication Critical patent/CA2065044A1/fr

Status Abandoned legal-status Critical Current

Links

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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
- A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
- A61K2800/5426—Polymers characterized by specific structures/properties characterized by the charge cationic

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Birds (AREA)
Inorganic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Marine Sciences & Fisheries (AREA)
Cosmetics (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002065044A 1989-08-18 1990-08-17 Compositions stabilisees et a odeur masquee pour le traitement des tissus keratinoides, des maladies de la peau et pour favoriser la guerison des plaies Abandoned CA2065044A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US39647489A	1989-08-18	1989-08-18
US396,474		1989-08-18

Publications (1)

Publication Number	Publication Date
CA2065044A1 true CA2065044A1 (fr)	1991-02-19

Family

ID=23567320

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002065044A Abandoned CA2065044A1 (fr)	1989-08-18	1990-08-17	Compositions stabilisees et a odeur masquee pour le traitement des tissus keratinoides, des maladies de la peau et pour favoriser la guerison des plaies

Country Status (6)

Country	Link
EP (1)	EP0487648A4 (fr)
JP (1)	JPH05503071A (fr)
AU (1)	AU6425590A (fr)
CA (1)	CA2065044A1 (fr)
IL (1)	IL95393A0 (fr)
WO (1)	WO1991002538A1 (fr)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW222591B (fr) *	1991-08-30	1994-04-21	Procter & Gamble
IT1252061B (it) *	1991-11-22	1995-05-29	Gentili Ist Spa	Composizioni per uso dermatologico e cosmetico
AU3328693A (en) *	1991-12-18	1993-07-19	Advanced Oxygen Technologies, Inc.	Treatment of fungal infections
DE4142319A1 (de) *	1991-12-20	1993-06-24	Henkel Kgaa	Wundantiseptikum
US5645827A (en) *	1992-09-30	1997-07-08	Union Carbide Chemicals & Plastics Technology Corporation	Muco-adhesive polymers
US5358706A (en) *	1992-09-30	1994-10-25	Union Carbide Chemicals & Plastics Technology Corporation	Muco-adhesive polymers
FR2704394B1 (fr) *	1993-04-27	1995-06-02	Boiron	Complément nutritionnel absorbable pour le traitement des cheveux et des ongles.
FR2705564B1 (fr) *	1993-05-25	1995-07-13	Oreal	Nouveau procédé de déformation permanente des cheveux et composition pour sa mise en Óoeuvre contenant en association un amino ou amidothiol et au moins un bromure minéral.
JP2735392B2 (ja) *	1993-07-28	1998-04-02	ファイザー・インコーポレーテッド	乾癬の治療法
US6113893A (en) *	1993-07-28	2000-09-05	Pfizer Inc.	Psoriasis treatment
GB9515373D0 (en) *	1995-07-21	1995-09-20	Unilever Plc	Hair styling method
FR2740341B1 (fr) *	1995-10-26	1997-12-19	Oreal	Utilisation de sel de lanthanide, d'etain, de zinc, de manganese, d'yttrium, de cobalt, de baryum, de strontium dans une composition pour la peau
FR2740340B1 (fr) *	1995-10-30	1997-12-05	Oreal	Utilisation d'acides carboxyliques porteurs d'une fonction soufree pour favoriser la desquamation de la peau ou stimuler le renouvellement epidermique
GB2320431B (en) *	1996-12-20	2000-08-30	Johnson & Johnson Medical	Compositions for the treatment of chronic wounds
WO1998038975A1 (fr) *	1997-03-03	1998-09-11	Quest International B.V.	Compositions pour traiter des cheveux et des poils, contenant une espece sulfureuse reductrice et un compose de zinc
BR9807810A (pt)	1997-03-03	2000-02-22	Quest Int	Composição para tratamento de cabelo , e, processo de redução do mau odor das composiçãoes para tratamento de cabelo contendo espécies de enxofre redutoras
GB9711447D0 (fr) *	1997-04-09	1997-07-30	Reckitt & Colman France
IT1291622B1 (it) *	1997-04-18	1999-01-11	Marcello Izzo	Uso dell'acido tioglicolico come agente depigmentante
US6169114B1 (en) *	1997-09-26	2001-01-02	Shiseido Company, Ltd.	Endermic liniment containing a thiol compound and zinc oxide
JP4111546B2 (ja) *	1997-12-15	2008-07-02	ウルトラデントプロダクツインコーポレイテッド	重合可能な隔離バリア、およびかかるバリアを形成しかつ使用する方法
DE19831043A1 (de) *	1998-07-13	2000-01-27	Deutsches Krebsforsch	Hemmung von Alopezie
US6497893B1 (en) *	1999-06-30	2002-12-24	Kimberly-Clark Worldwide, Inc.	Silk protein treatment composition and treated substrate for transfer to skin
EP1145707A4 (fr) *	1999-01-28	2005-08-31	Shiseido Co Ltd	Compositions destinees a un usage externe
US6500443B1 (en)	1999-06-30	2002-12-31	Kimberly-Clark Worldwide, Inc.	Delivery of a sacrificial substrate to inhibit protease permeation into skin
US6506394B1 (en)	1999-06-30	2003-01-14	Kimberly-Clark Worldwide, Inc.	Delivery of a botanical extract to a treated substrate for transfer to skin
WO2001000156A1 (fr) *	1999-06-30	2001-01-04	Kimberly-Clark Worldwide, Inc.	Administration d"un agent benefique pour la peau sur un substrat traite
US6371984B1 (en)	1999-09-13	2002-04-16	Keraplast Technologies, Ltd.	Implantable prosthetic or tissue expanding device
US6503524B1 (en)	2000-06-16	2003-01-07	Kimberly-Clark Worldwide, Inc.	Delivery of a skin health benefit agent to a treated substrate for transfer to skin
AU2002223679A1 (en) *	2000-12-19	2002-07-01	Unilever Plc	Hair treatment composition
ES2426420T3 (es)	2002-01-28	2013-10-23	Keraplast Technologies Ltd.	Péptidos de queratina bioactivos
US20030219465A1 (en) *	2002-05-23	2003-11-27	Suresh Kumar Gidwani	Composition for delivery of dithranol
WO2004024176A1 (fr) *	2002-08-30	2004-03-25	Henkel Kommanditgesellschaft Auf Aktien	Combinaison synergique de proteines de soie
AT502435B1 (de) *	2002-11-19	2008-01-15	Oekopharm Forschungs Und Entwi	Pharmazeutische zusammensetzung umfassend ein wasserstoffübertragendes coenzym und chlorophyll
US7439012B2 (en)	2004-08-17	2008-10-21	Wake Forest University Health Sciences	Ambient stored blood plasma expanders containing keratose
DE102004046063A1 (de) *	2004-09-22	2006-03-23	Henkel Kgaa	Geruchsreduzierendes Haarbehandlungsmittel
GB0511499D0 (en) *	2005-06-06	2005-07-13	Medpharm Ltd	Topical ungual formulations
US8920827B2 (en)	2005-10-21	2014-12-30	Wake Forest University Health Sciences	Keratin bioceramic compositions
WO2007095151A2 (fr)	2006-02-10	2007-08-23	Wake Forest University Health Sciences	Régénération nerveuse utilisant des bio-matériaux de kératine
US8273702B2 (en)	2006-02-17	2012-09-25	Wake Forest University Health Sciences	Wound healing compositions containing keratin biomaterials
AU2007217898A1 (en)	2006-02-17	2007-08-30	Wake Forest University Health Sciences	Coatings and biomedical implants formed from keratin biomaterials
JP2008063334A (ja) *	2006-08-10	2008-03-21	Lion Corp	水溶性有効成分の付着化組成物及び水溶性有効成分の付着方法
GB2458531A (en) *	2008-03-26	2009-09-30	Boots Co Plc	Strengthening hair care composition comprising mild reducing agent
WO2010093882A1 (fr)	2009-02-13	2010-08-19	Wake Forest University Health Sciences	Biomatériaux de kératine pour culture de cellules et procédés d'utilisation
CA2791386C (fr)	2010-03-05	2023-10-31	Wake Forest University Health Sciences	Composition de gel de keratine servant a controler la distribution d'un compose
US8545893B2 (en)	2010-03-08	2013-10-01	Wake Forest University Health Sciences	Keratin biomaterials for treatment of ischemia
CA2818166C (fr)	2010-11-17	2019-04-30	Wake Forest University Health Sciences	Compositions keratiniques pour le traitement d'une deficience ou lesion osseuse
EP2934695B1 (fr) *	2012-12-19	2016-11-30	Colgate-Palmolive Company	Produits antitranspirants contenant une protéine et des sels antitranspirants
WO2016094887A2 (fr) *	2014-12-12	2016-06-16	Robert Valentine Kasowski	Agent retardateur de flammes, et utilisations de l'agent retardateur de flammes
CN116585257A (zh) *	2016-04-13	2023-08-15	诺万公司	用于治疗感染的组合物、系统、试剂盒和方法
EP3544573A1 (fr) *	2016-11-25	2019-10-02	Urgo Recherche Innovation et Développement	Composition filmogène
CN113134028B (zh) *	2021-04-28	2022-04-12	维尼健康（深圳）股份有限公司	一种伤口消毒液及其制备方法
WO2024142417A1 (fr) *	2022-12-28	2024-07-04	ハウスウェルネスフーズ株式会社	Agent de rétention d'ingrédient actif

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3842848A (en) *	1971-05-27	1974-10-22	Wilson Sinclair Co	Keratin polypeptide hydrolyzates as hair treating agents
US4438102A (en) *	1982-08-10	1984-03-20	Ciro's Touch, Ltd.	Method of promoting tissue growth
GB2160419B (en) *	1984-06-08	1990-02-14	Crestol Ltd	Treatment of hair, skin and nails
US4909986A (en) *	1985-07-23	1990-03-20	Dainippon Ink	Aqueous deodorants and deodorizing methods
AU604940B2 (en) *	1988-07-13	1991-01-03	Aikoh Co. Ltd.	A reaction typed deodorant composition having a corrosion-inhibiting activity
ATE118350T1 (de) *	1988-07-22	1995-03-15	Morris John Co Inc	Zusammensetzungen und verfahren zur behandlung von hautkrankheiten und zur aktivierung der wundheilung.

1990
- 1990-08-16 IL IL95393A patent/IL95393A0/xx unknown
- 1990-08-17 AU AU64255/90A patent/AU6425590A/en not_active Abandoned
- 1990-08-17 CA CA002065044A patent/CA2065044A1/fr not_active Abandoned
- 1990-08-17 WO PCT/US1990/004649 patent/WO1991002538A1/fr not_active Ceased
- 1990-08-17 EP EP19900914307 patent/EP0487648A4/en not_active Withdrawn
- 1990-08-17 JP JP2513384A patent/JPH05503071A/ja active Pending

Also Published As

Publication number	Publication date
JPH05503071A (ja)	1993-05-27
EP0487648A4 (en)	1993-03-31
EP0487648A1 (fr)	1992-06-03
IL95393A0 (en)	1991-06-30
WO1991002538A1 (fr)	1991-03-07
AU6425590A (en)	1991-04-03

Publication	Publication Date	Title
CA2065044A1 (fr)	1991-02-19	Compositions stabilisees et a odeur masquee pour le traitement des tissus keratinoides, des maladies de la peau et pour favoriser la guerison des plaies
US5047249A (en)	1991-09-10	Compositions and methods for treating skin conditions and promoting wound healing
JP3157823B2 (ja)	2001-04-16	含水ペースト型製薬組成物
US3252866A (en)	1966-05-24	2-hydrocarbon substituted-amido mercaptopropionamides in hair waving compositions and processes
EP0368253A2 (fr)	1990-05-16	Système de délivrance de principes actifs pharmaceutiques ou thérapeutiques
JPH08502509A (ja)	1996-03-19	化粧品組成物
CN101980687A (zh)	2011-02-23	令气味和刺激消减的脱毛剂套盒
WO1988000186A1 (fr)	1988-01-14	Composition pour l'alteration permanente de la stucture des cheveux
JP2002080401A (ja)	2002-03-19	ゲル状外用剤組成物
EP0425507B1 (fr)	1995-02-15	Compositions et procedes pour traiter des infections dermiques et activer la cicatrisation
JP2884428B2 (ja)	1999-04-19	洗浄組成物
JPH07101831A (ja)	1995-04-18	養毛化粧料
JPH05221821A (ja)	1993-08-31	皮膚化粧料
JPH01501001A (ja)	1989-04-06	毛髪の永久的構造変更に使用される組成物
AU614832B2 (en)	1991-09-12	Storage-stable compositions and methods for treating keratinous tissue
JPH09124434A (ja)	1997-05-13	皮膚外用剤
US3917815A (en)	1975-11-04	Cosmetic compositions containing N-oxypyridyl derivatives
JPH05170625A (ja)	1993-07-09	養毛化粧料
JP3272743B2 (ja)	2002-04-08	安定なｓｏｄ活性を有する胎盤または肝臓抽出液およびそれを含有する外用剤組成物
JPH04305517A (ja)	1992-10-28	養毛化粧料
US7182939B2 (en)	2007-02-27	Hair tonic composition
JP3434635B2 (ja)	2003-08-11	含水化粧料の変臭・変色防止方法
JPH06145037A (ja)	1994-05-24	皮膚外用剤
JPH069348A (ja)	1994-01-18	養毛化粧料
EP0087374B1 (fr)	1987-05-27	Produit à base d'allantoine et de protéines animales hydrolysées

Legal Events

Date	Code	Title	Description
1998-08-17	FZDE	Discontinued