CA2064710A1 - Proteine recombinante qui se lie a un antigene viral complexe de vih-1 - Google Patents

Proteine recombinante qui se lie a un antigene viral complexe de vih-1

Info

Publication number: CA2064710A1
Authority: CA; Canada
Prior art keywords: protein; sc3d6; ser; val; stated
Prior art date: 1990-05-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA 2064710

Other languages

English (en)

Inventor

Martin Felgenhauer

Gottfried Himmler

Johann Kohl

Franz Steindl

Alois Jungbauer

Hermann Katinger

Florian Ruker

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-29

Filing date

1991-05-28

Publication date

1991-11-30

1991-05-28 Application filed by Individual filed Critical Individual

1991-11-30 Publication of CA2064710A1 publication Critical patent/CA2064710A1/fr

Status Abandoned legal-status Critical Current

Links

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108091007433 antigens Proteins 0.000 title claims abstract description 17
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108010008281 Recombinant Fusion Proteins Proteins 0.000 title claims abstract description 11
230000003612 virological effect Effects 0.000 title claims abstract description 4
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238000000746 purification Methods 0.000 claims abstract description 12
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UPJONISHZRADBH-XPUUQOCRSA-N Val-Glu Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O UPJONISHZRADBH-XPUUQOCRSA-N 0.000 description 1
UEHRGZCNLSWGHK-DLOVCJGASA-N Val-Glu-Val Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O UEHRGZCNLSWGHK-DLOVCJGASA-N 0.000 description 1
DJEVQCWNMQOABE-RCOVLWMOSA-N Val-Gly-Asp Chemical compound CC(C)[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)O)N DJEVQCWNMQOABE-RCOVLWMOSA-N 0.000 description 1
XTDDIVQWDXMRJL-IHRRRGAJSA-N Val-Leu-His Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)NC(=O)[C@H](C(C)C)N XTDDIVQWDXMRJL-IHRRRGAJSA-N 0.000 description 1
VHIZXDZMTDVFGX-DCAQKATOSA-N Val-Ser-Leu Chemical compound CC(C)C[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)N VHIZXDZMTDVFGX-DCAQKATOSA-N 0.000 description 1
PZTZYZUTCPZWJH-FXQIFTODSA-N Val-Ser-Ser Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)O)N PZTZYZUTCPZWJH-FXQIFTODSA-N 0.000 description 1
QPJSIBAOZBVELU-BPNCWPANSA-N Val-Tyr-Ala Chemical compound C[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](C(C)C)N QPJSIBAOZBVELU-BPNCWPANSA-N 0.000 description 1
STTYIMSDIYISRG-UHFFFAOYSA-N Valyl-Serine Chemical compound CC(C)C(N)C(=O)NC(CO)C(O)=O STTYIMSDIYISRG-UHFFFAOYSA-N 0.000 description 1
108010006886 Vitrogen Proteins 0.000 description 1
241000607479 Yersinia pestis Species 0.000 description 1
101150008263 accD gene Proteins 0.000 description 1
FKNHDDTXBWMZIR-GEMLJDPKSA-N acetic acid;(2s)-1-[(2r)-2-amino-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid Chemical compound CC(O)=O.SC[C@H](N)C(=O)N1CCC[C@H]1C(O)=O FKNHDDTXBWMZIR-GEMLJDPKSA-N 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 1
229960005305 adenosine Drugs 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
108010008685 alanyl-glutamyl-aspartic acid Proteins 0.000 description 1
108010069020 alanyl-prolyl-glycine Proteins 0.000 description 1
108010044940 alanylglutamine Proteins 0.000 description 1
108010087924 alanylproline Proteins 0.000 description 1
108010050025 alpha-glutamyltryptophan Proteins 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
108010013835 arginine glutamate Proteins 0.000 description 1
108010008355 arginyl-glutamine Proteins 0.000 description 1
108010052670 arginyl-glutamyl-glutamic acid Proteins 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
238000002306 biochemical method Methods 0.000 description 1
229960002685 biotin Drugs 0.000 description 1
235000020958 biotin Nutrition 0.000 description 1
239000011616 biotin Substances 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
238000010276 construction Methods 0.000 description 1
239000013256 coordination polymer Substances 0.000 description 1
108010060199 cysteinylproline Proteins 0.000 description 1
229960005156 digoxin Drugs 0.000 description 1
239000013024 dilution buffer Substances 0.000 description 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
238000010828 elution Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
239000006167 equilibration buffer Substances 0.000 description 1
238000000605 extraction Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
150000002270 gangliosides Chemical class 0.000 description 1
108010078144 glutaminyl-glycine Proteins 0.000 description 1
VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 description 1
108010010096 glycyl-glycyl-tyrosine Proteins 0.000 description 1
108010048994 glycyl-tyrosyl-alanine Proteins 0.000 description 1
YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 description 1
108010050848 glycylleucine Proteins 0.000 description 1
238000003384 imaging method Methods 0.000 description 1
230000008105 immune reaction Effects 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
210000003000 inclusion body Anatomy 0.000 description 1
238000011534 incubation Methods 0.000 description 1
150000002540 isothiocyanates Chemical class 0.000 description 1
101150085091 lat-2 gene Proteins 0.000 description 1
108010012058 leucyltyrosine Proteins 0.000 description 1
239000006166 lysate Substances 0.000 description 1
108010064235 lysylglycine Proteins 0.000 description 1
108020004999 messenger RNA Proteins 0.000 description 1
238000005065 mining Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
201000000050 myeloid neoplasm Diseases 0.000 description 1
235000017524 noni Nutrition 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
229940055729 papain Drugs 0.000 description 1
235000019834 papain Nutrition 0.000 description 1
101150040383 pel2 gene Proteins 0.000 description 1
101150050446 pelB gene Proteins 0.000 description 1
NRNCYVBFPDDJNE-UHFFFAOYSA-N pemoline Chemical compound O1C(N)=NC(=O)C1C1=CC=CC=C1 NRNCYVBFPDDJNE-UHFFFAOYSA-N 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
239000013600 plasmid vector Substances 0.000 description 1
229920002492 poly(sulfone) Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
239000013641 positive control Substances 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
108010031719 prolyl-serine Proteins 0.000 description 1
108010070643 prolylglutamic acid Proteins 0.000 description 1
108010053725 prolylvaline Proteins 0.000 description 1
235000019419 proteases Nutrition 0.000 description 1
230000002797 proteolythic effect Effects 0.000 description 1
239000013014 purified material Substances 0.000 description 1
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210000003705 ribosome Anatomy 0.000 description 1
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238000010561 standard procedure Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
QGVNJRROSLYGKF-UHFFFAOYSA-N thiobarbital Chemical compound CCC1(CC)C(=O)NC(=S)NC1=O QGVNJRROSLYGKF-UHFFFAOYSA-N 0.000 description 1
101150014006 thrA gene Proteins 0.000 description 1
108010080629 tryptophan-leucine Proteins 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Hematology (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

CA 2064710 1990-05-29 1991-05-28 Proteine recombinante qui se lie a un antigene viral complexe de vih-1 Abandoned CA2064710A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ATA1178/90		1990-05-29
AT117890A AT396939B (de)	1990-05-29	1990-05-29	Komplexes virales antigen von hiv-1 bindendes rekombinantes protein

Publications (1)

Publication Number	Publication Date
CA2064710A1 true CA2064710A1 (fr)	1991-11-30

Family

ID=3508299

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA 2064710 Abandoned CA2064710A1 (fr)	1990-05-29	1991-05-28	Proteine recombinante qui se lie a un antigene viral complexe de vih-1

Country Status (7)

Country	Link
EP (1)	EP0484500A1 (fr)
JP (1)	JPH05501062A (fr)
AT (1)	AT396939B (fr)
CA (1)	CA2064710A1 (fr)
SK (1)	SK160391A3 (fr)
WO (1)	WO1991018983A1 (fr)
YU (1)	YU114691A (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8440189B2 (en)	1999-01-15	2013-05-14	Biogen Idec Ma Inc.	Antagonists of TWEAK and of TWEAK receptor and their use to treat immunological disorders
US8728475B2 (en)	2005-05-10	2014-05-20	Biogen Idec Ma Inc.	Methods for treating inflammatory bowel disease
US9011859B2 (en)	2002-04-09	2015-04-21	Biogen Idec Ma Inc.	Methods for treating TWEAK-related conditions
US9730947B2 (en)	2005-06-13	2017-08-15	Biogen Ma Inc.	Method of treating lupus nephritis
US9775899B2 (en)	2005-02-17	2017-10-03	Biogen Ma Inc.	Treating neurological disorders

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5808032A (en) *	1992-03-30	1998-09-15	Suntory Limited	Anti-HBS antibody genes and expression plasmids therefor
CA2162577C (fr) *	1993-05-10	2005-06-14	Fumihiko Matsuda	Segments de gene vh d'immunoglobuline humaine et fragments d'adn qui en renferment
US6936705B1 (en)	1993-05-10	2005-08-30	Japan Tobacco Inc.	Human immunoglobulin VH gene segments and DNA fragments containing the same
US6096878A (en) *	1993-05-10	2000-08-01	Japan Tobacco Inc.	Human immunoglobulin VH gene segments and DNA fragments containing the same
CA2402729A1 (fr) *	2000-03-15	2001-09-20	Incyte Genomics, Inc.	Proteines de reponse immunitaire humaines
UA96416C2 (uk) *	2005-05-27	2011-11-10	Байоджэн Айдэк Ма Инк.	Антитіло, яке зв'язується з tweak людини
JP2010528583A (ja) *	2007-06-11	2010-08-26	エーシーイミューンソシエテアノニム	アミロイドβに対するヒト化抗体
US8048420B2 (en)	2007-06-12	2011-11-01	Ac Immune S.A.	Monoclonal antibody
US8613923B2 (en)	2007-06-12	2013-12-24	Ac Immune S.A.	Monoclonal antibody
DK2238166T3 (da)	2007-10-05	2014-01-27	Ac Immune Sa	Anvendelse af et anti-amyloid-beta-antistof ved øjensygdomme
EP2899209A1 (fr)	2008-04-29	2015-07-29	Abbvie Inc.	Immunoglobuline à double domaine variable et ses utilisations
EP2297208A4 (fr)	2008-06-03	2012-07-11	Abbott Lab	Immunoglobulines à double domaine variable et leurs utilisations
RU2012112550A (ru)	2009-09-01	2013-10-10	Эбботт Лэборетриз	Иммуноглобулины с двумя вариабельными доменами и их применение
US8716450B2 (en)	2009-10-15	2014-05-06	Abbvie Inc.	Dual variable domain immunoglobulins and uses thereof
UY32979A (es)	2009-10-28	2011-02-28	Abbott Lab	Inmunoglobulinas con dominio variable dual y usos de las mismas
AU2011282536B2 (en)	2010-07-30	2015-12-24	Ac Immune S.A.	Safe and functional humanized anti beta-amyloid antibody
TW201206473A (en)	2010-08-03	2012-02-16	Abbott Lab	Dual variable domain immunoglobulins and uses thereof
PE20140229A1 (es)	2010-08-26	2014-03-27	Abbvie Inc	Inmunoglobulinas con dominio variable dual y usos de las mismas
TW201333035A (zh)	2011-12-30	2013-08-16	Abbvie Inc	針對ｉｌ－１３及／或ｉｌ－１７之雙特異性結合蛋白
UY35110A (es)	2012-11-01	2014-05-30	Abbvie Inc	Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas
CA2904448A1 (fr)	2013-03-15	2014-09-18	Tariq Ghayur	Proteines de liaison specifiques a domaines variables doubles dirigees contre il-1.beta. et/ou il-17
WO2016094881A2 (fr)	2014-12-11	2016-06-16	Abbvie Inc.	Protéines de liaison à lrp-8
TW201710286A (zh)	2015-06-15	2017-03-16	艾伯維有限公司	抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4851341A (en) *	1986-12-19	1989-07-25	Immunex Corporation	Immunoaffinity purification system
NZ226414A (en) *	1987-10-02	1992-07-28	Genentech Inc	Cd4 peptide adhesion variants and their preparation and use
EP0312164A1 (fr) *	1987-10-16	1989-04-19	Merck & Co. Inc.	Purification d'antigènes recombinants du virus epstein-barr à partir de cellules vero, cellules de levure ou cellules L
JPH02502251A (ja) *	1987-11-13	1990-07-26	ヘルマン　カーティンガー	ヒトのモノクローン性抗ｈｉｖ‐１‐抗体

1990
- 1990-05-29 AT AT117890A patent/AT396939B/de not_active IP Right Cessation
1991
- 1991-05-28 WO PCT/AT1991/000067 patent/WO1991018983A1/fr not_active Ceased
- 1991-05-28 JP JP3509464A patent/JPH05501062A/ja active Pending
- 1991-05-28 YU YU114691A patent/YU114691A/sh unknown
- 1991-05-28 EP EP19910910271 patent/EP0484500A1/fr not_active Withdrawn
- 1991-05-28 CA CA 2064710 patent/CA2064710A1/fr not_active Abandoned
- 1991-05-29 SK SK160391A patent/SK160391A3/sk unknown

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8440189B2 (en)	1999-01-15	2013-05-14	Biogen Idec Ma Inc.	Antagonists of TWEAK and of TWEAK receptor and their use to treat immunological disorders
US9011859B2 (en)	2002-04-09	2015-04-21	Biogen Idec Ma Inc.	Methods for treating TWEAK-related conditions
US9775899B2 (en)	2005-02-17	2017-10-03	Biogen Ma Inc.	Treating neurological disorders
US8728475B2 (en)	2005-05-10	2014-05-20	Biogen Idec Ma Inc.	Methods for treating inflammatory bowel disease
US9730947B2 (en)	2005-06-13	2017-08-15	Biogen Ma Inc.	Method of treating lupus nephritis

Also Published As

Publication number	Publication date
YU114691A (sh)	1994-06-10
WO1991018983A1 (fr)	1991-12-12
ATA117890A (de)	1993-05-15
JPH05501062A (ja)	1993-03-04
EP0484500A1 (fr)	1992-05-13
SK160391A3 (en)	1995-07-11
AT396939B (de)	1993-12-27

Publication	Publication Date	Title
CA2064710A1 (fr)	1991-11-30	Proteine recombinante qui se lie a un antigene viral complexe de vih-1
EP0199301B2 (fr)	1997-07-09	Protéine recombinante d'enveloppe du virus du syndrome d'immunodéficience acquise (SIDA) et procédé pour l'analyse du SIDA
KR950008570B1 (ko)	1995-08-03	임파선중 관련 바이러스(lav)의 코어 단백질 인식용 단일 클론 항체가 인식하는 폴리펩타이드의 정제 방법과 그러한 항체를 분비하는 하이브리도마의 제조방법
NO870027L (no)	1987-07-07	Ekspresjon av htlv-iii gag-gen.
KR20050108389A (ko)	2005-11-16	모노클로날 항체 및 이것을 생산하는 하이브리도마
JPH02107196A (ja)	1990-04-19	抗ＨＩＶ―１ｐ２４マウスモノクローナル抗体、その産生細胞株およびそれを用いたイムノアッセイ法
EP0540586A1 (fr)	1993-05-12	Domaines d'agglutination
NO300462B1 (no)	1997-06-02	Monoklonale antistoffer og peptider som kan anvendes til diagnose av HIV-infeksjoner
JP3536731B2 (ja)	2004-06-14	ＨＩＶ−１ｐ２４抗原の免疫測定方法及び試薬
CA2028172A1 (fr)	1991-04-24	Peptides de htlv-i a enveloppe synthetique
US6171596B1 (en)	2001-01-09	Oligomeric HIV-1 envelope glycoproteins
CA1340878C (fr)	2000-01-25	Production bacterienne de fragments de proteine de l'enveloppe du retrovirus de la leucemie (lymphotropique) des cellules t de l'humain (htlu-i), que son usage dans le depisage seroepidemiologique de tumeurs malignes lymphatiques chez les humains
KR102453605B1 (ko)	2022-10-12	신규 펩타이드 태그, 이에 결합하는 항체 및 이들의 용도
JPH06510790A (ja)	1994-12-01	分泌Ｍａｃ−２結合糖タンパク質
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Park et al.	2000	Characterization and gene cloning of monoclonal antibody specific for the hepatitis B virus X protein
CN110078820A (zh)	2019-08-02	牛白血病病毒抗体及检测试剂盒
US6039957A (en)	2000-03-21	Oligomeric HIV-1 envelope glycoproteins
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JP4029153B2 (ja)	2008-01-09	核酸、当該核酸を含むニワトリ由来モノクローナル抗体及びこれを用いたプリオンタンパク質の検出方法

Legal Events

Date	Code	Title	Description
1995-05-17	EEER	Examination request
1999-01-11	FZDE	Dead

CA2064710A1 - Proteine recombinante qui se lie a un antigene viral complexe de vih-1 - Google Patents

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Links

Classifications

Landscapes

Applications Claiming Priority (2)

Publications (1)

Family

ID=3508299

Family Applications (1)

Country Status (7)

Cited By (5)

Families Citing this family (23)

Family Cites Families (4)

Cited By (5)

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