BRPI1012673A2 - Method of Preparation of 1-amino-1,3,3,5,5-pentamethylcyclohexane - Google Patents
Method of Preparation of 1-amino-1,3,3,5,5-pentamethylcyclohexaneInfo
- Publication number
- BRPI1012673A2 BRPI1012673A2 BRPI1012673A BRPI1012673A BRPI1012673A2 BR PI1012673 A2 BRPI1012673 A2 BR PI1012673A2 BR PI1012673 A BRPI1012673 A BR PI1012673A BR PI1012673 A BRPI1012673 A BR PI1012673A BR PI1012673 A2 BRPI1012673 A2 BR PI1012673A2
- Authority
- BR
- Brazil
- Prior art keywords
- pentamethylcyclohexane
- amino
- preparation
- neramexane
- chloroacetamido
- Prior art date
Links
- OGZQTTHDGQBLBT-UHFFFAOYSA-N neramexane Chemical compound CC1(C)CC(C)(C)CC(C)(N)C1 OGZQTTHDGQBLBT-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229950004543 neramexane Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
método de preparo de 1-amino- 1,3,3,5,5-pentametilciclohexano a invenção refere-se a um método de produção de 1- amino-1,3,3,5,5-pentametilciclohexano (neramexano) ou um sal farmaceuticamente aceitável dele, que compreende a etapa de aquecer uma mistura compreendendo 1-cloroacetamido-1,3,3,5,5- pentametilciclohexano, tiouréia e água.Method of Preparation of 1-Amino-1,3,3,5,5-pentamethylcyclohexane The invention relates to a method of producing 1-amino-1,3,3,5,5-pentamethylcyclohexane (neramexane) or a a pharmaceutically acceptable salt thereof, comprising the step of heating a mixture comprising 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, thiourea and water.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26978209P | 2009-06-29 | 2009-06-29 | |
| EP09084658 | 2009-06-29 | ||
| PCT/EP2010/003924 WO2011000541A1 (en) | 2009-06-29 | 2010-06-28 | Method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1012673A2 true BRPI1012673A2 (en) | 2019-04-02 |
Family
ID=67251266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1012673A BRPI1012673A2 (en) | 2009-06-29 | 2010-06-28 | Method of Preparation of 1-amino-1,3,3,5,5-pentamethylcyclohexane |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BRPI1012673A2 (en) |
-
2010
- 2010-06-28 BR BRPI1012673A patent/BRPI1012673A2/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A, 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2518 DE 09-04-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] |