BRPI1009900A2 - métodos para a preparação de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfônico e seus precursores - Google Patents
métodos para a preparação de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfônico e seus precursoresInfo
- Publication number
- BRPI1009900A2 BRPI1009900A2 BRPI1009900A BRPI1009900A BRPI1009900A2 BR PI1009900 A2 BRPI1009900 A2 BR PI1009900A2 BR PI1009900 A BRPI1009900 A BR PI1009900A BR PI1009900 A BRPI1009900 A BR PI1009900A BR PI1009900 A2 BRPI1009900 A2 BR PI1009900A2
- Authority
- BR
- Brazil
- Prior art keywords
- dioxo
- diazabicyclo
- precursors
- ethyl
- preparation
- Prior art date
Links
- BDABGOLMYNHHTR-UHFFFAOYSA-N Perzinfotel Chemical compound OP(O)(=O)CCN1CCCNC2=C1C(=O)C2=O BDABGOLMYNHHTR-UHFFFAOYSA-N 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16151309P | 2009-03-19 | 2009-03-19 | |
| PCT/US2010/027908 WO2010108063A1 (en) | 2009-03-19 | 2010-03-19 | Methods for the preparation of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]phosphonic acid and precursors thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1009900A2 true BRPI1009900A2 (pt) | 2016-03-15 |
Family
ID=42227623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1009900A BRPI1009900A2 (pt) | 2009-03-19 | 2010-03-19 | métodos para a preparação de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfônico e seus precursores |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20120116074A1 (pt) |
| EP (1) | EP2408790A1 (pt) |
| JP (1) | JP2012521352A (pt) |
| KR (1) | KR20110139274A (pt) |
| CN (1) | CN102356087A (pt) |
| AR (1) | AR075900A1 (pt) |
| AU (1) | AU2010226479A1 (pt) |
| BR (1) | BRPI1009900A2 (pt) |
| CA (1) | CA2754390A1 (pt) |
| MX (1) | MX2011009716A (pt) |
| WO (1) | WO2010108063A1 (pt) |
| ZA (1) | ZA201107412B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8547100B2 (en) * | 2008-02-25 | 2013-10-01 | Koninklijke Philips N.V. | Magnetic resonance gradient coil iso-plane backbone for radiation detectors of 511Kev |
| WO2010121133A2 (en) * | 2009-04-17 | 2010-10-21 | The General Hospital Corporation | Multimodal imaging of fibrin |
| KR101474063B1 (ko) | 2012-05-23 | 2014-12-19 | 동국대학교 산학협력단 | 피브린 표적 펩타이드 서열이 결합된 글라이콜 키토산-금 나노입자를 포함하는 혈전 탐지용 ｃｔ 조영제 |
| EP3077009A4 (en) * | 2013-12-03 | 2017-06-14 | The General Hospital Corporation | Molecular imaging probes |
| BR112019023249A8 (pt) | 2017-05-05 | 2021-02-23 | Centre For Probe Dev And Commercialization | anticorpos monoclonais igf-1r e usos dos mesmos |
| US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
| IL270453B2 (en) | 2017-05-05 | 2025-05-01 | Fusion Pharmaceuticals Inc | Pharmacokinetic enhancements of bifunctional chelates and uses thereof |
| EP4072425A4 (en) * | 2019-12-09 | 2023-08-23 | Sino Canada Health Institute Inc. | METHOD OF MONITORING PET READOUT POSITIONS USING MRI FILING MARKS |
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| CH584232A5 (pt) * | 1973-07-26 | 1977-01-31 | Ciba Geigy Ag | |
| US4899755A (en) | 1985-05-08 | 1990-02-13 | The General Hospital Corporation | Hepatobiliary NMR contrast agents |
| US5021556A (en) | 1987-07-22 | 1991-06-04 | Neorx Corporation | Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides |
| US5075099A (en) | 1988-05-31 | 1991-12-24 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| EP0489869B1 (en) | 1989-08-28 | 1998-11-11 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic nmr imaging |
| US5367080A (en) | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
| US5168103A (en) | 1991-01-22 | 1992-12-01 | American Home Products Corporation | [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives |
| ATE188387T1 (de) | 1991-02-08 | 2000-01-15 | Diatide Inc | Technetium-99m markierte polypeptide zur bildformung |
| US5849261A (en) | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US5965107A (en) | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| HUT76623A (en) | 1994-03-16 | 1997-10-28 | Mallinckrodt Medical Inc | Stabilization of peptides and proteins for radiopharmaceutical use |
| US5582814A (en) | 1994-04-15 | 1996-12-10 | Metasyn, Inc. | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging |
| TW319763B (pt) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| US5672877A (en) | 1996-03-27 | 1997-09-30 | Adac Laboratories | Coregistration of multi-modality data in a medical imaging system |
| KR20060025233A (ko) | 1996-04-01 | 2006-03-20 | 에픽스 메디칼, 인코포레이티드 | 생체활성화 진단용 영상 콘트라스트 제제 |
| WO1998018496A2 (en) | 1996-10-28 | 1998-05-07 | Nycomed Imaging As | Contrast agents |
| US5919967A (en) | 1997-04-11 | 1999-07-06 | Epix Medical, Inc. | Process for synthesizing phosphodiesters |
| US5886142A (en) | 1997-05-20 | 1999-03-23 | Thomas Jefferson University | Radiolabeled thrombus imaging agents |
| NZ502509A (en) * | 1997-08-01 | 2002-08-28 | Wyeth Corp | Process for the preparation of [2-((8,9)- dioxo-2,6-diazabicyclo[5.2.0]-non-1(7)-en-2-yl)-ethyl] phosphonic acid |
| JP2001518523A (ja) | 1997-10-02 | 2001-10-16 | エピックス メディカル， インコーポレイテッド | インターベンショナル療法をモニタリングするためのコントラスト増強型診断的画像化方法 |
| EP1203026A4 (en) | 1999-07-29 | 2005-03-16 | Dyax Corp | FRACTIONS BINDING FIBRIN |
| US6984373B2 (en) | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
| US6549798B2 (en) | 2001-02-07 | 2003-04-15 | Epix Medical, Inc. | Magnetic resonance angiography data |
| TWI240632B (en) | 2001-07-30 | 2005-10-01 | Epix Medical Inc | Purified peptides for peptide-based multimeric targeted contrast agents |
| TWI221406B (en) | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
| DE10141186A1 (de) | 2001-08-22 | 2003-03-20 | Siemens Ag | Einrichtung zum Bearbeiten von Bildern, insbesondere medizinischen Bildern |
| UA78529C2 (en) | 2001-10-10 | 2007-04-10 | Wyeth Corp | Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain |
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| US20060155120A1 (en) * | 2003-05-23 | 2006-07-13 | Amedio John C | Optically pure and enriched isomers of chelating ligands and contrast agents |
| AU2004259028C1 (en) | 2003-07-24 | 2009-12-24 | Bracco Imaging S.P.A. | Stable radiopharmaceutical compositions and methods for preparation |
| GT200400213A (es) | 2003-10-22 | 2007-09-05 | Metodos para la preparacion del acido {2-[(8,9)-dioxo-2,6-diaza-biciclo[5.2.0]-non-1(7)-en-2-il]etil} fosfonico y esteres del mismo | |
| US20070111947A1 (en) | 2005-10-14 | 2007-05-17 | Mcmurry Thomas J | Fibrin targeted therapeutics |
| WO2008073458A2 (en) * | 2006-12-11 | 2008-06-19 | Bracco Imaging S.P.A. | Fibrin-binding peptides and conjugates thereof |
| CN101896205A (zh) | 2007-08-27 | 2010-11-24 | 惠氏有限责任公司 | 使用nmda拮抗剂用于获得麻醉剂节约效果的组合物和方法 |
-
2010
- 2010-03-19 MX MX2011009716A patent/MX2011009716A/es not_active Application Discontinuation
- 2010-03-19 CN CN2010800119434A patent/CN102356087A/zh active Pending
- 2010-03-19 AR ARP100100895A patent/AR075900A1/es not_active Application Discontinuation
- 2010-03-19 AU AU2010226479A patent/AU2010226479A1/en not_active Abandoned
- 2010-03-19 CA CA2754390A patent/CA2754390A1/en not_active Abandoned
- 2010-03-19 EP EP10710739A patent/EP2408790A1/en not_active Withdrawn
- 2010-03-19 JP JP2012500984A patent/JP2012521352A/ja not_active Withdrawn
- 2010-03-19 BR BRPI1009900A patent/BRPI1009900A2/pt not_active Application Discontinuation
- 2010-03-19 WO PCT/US2010/027908 patent/WO2010108063A1/en not_active Ceased
- 2010-03-19 US US13/256,777 patent/US20120116074A1/en not_active Abandoned
- 2010-03-19 KR KR1020117024351A patent/KR20110139274A/ko not_active Ceased
- 2010-04-16 US US13/256,795 patent/US9200017B2/en active Active
-
2011
- 2011-10-10 ZA ZA2011/07412A patent/ZA201107412B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20110139274A (ko) | 2011-12-28 |
| AR075900A1 (es) | 2011-05-04 |
| MX2011009716A (es) | 2011-10-17 |
| WO2010108063A1 (en) | 2010-09-23 |
| EP2408790A1 (en) | 2012-01-25 |
| JP2012521352A (ja) | 2012-09-13 |
| US9200017B2 (en) | 2015-12-01 |
| ZA201107412B (en) | 2012-07-25 |
| CA2754390A1 (en) | 2010-09-23 |
| US20120116074A1 (en) | 2012-05-10 |
| US20120077958A1 (en) | 2012-03-29 |
| CN102356087A (zh) | 2012-02-15 |
| AU2010226479A1 (en) | 2011-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |