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BRPI0919635A8 - PROCESS FOR PREPARING CINACALCET - Google Patents

PROCESS FOR PREPARING CINACALCET

Info

Publication number
BRPI0919635A8
BRPI0919635A8 BRPI0919635A BRPI0919635A BRPI0919635A8 BR PI0919635 A8 BRPI0919635 A8 BR PI0919635A8 BR PI0919635 A BRPI0919635 A BR PI0919635A BR PI0919635 A BRPI0919635 A BR PI0919635A BR PI0919635 A8 BRPI0919635 A8 BR PI0919635A8
Authority
BR
Brazil
Prior art keywords
cinacalcet
preparing cinacalcet
preparing
propan
intermediates
Prior art date
Application number
BRPI0919635A
Other languages
Portuguese (pt)
Inventor
Soriato Giorgio
Catozzi Nicola
Foletto Johnny
Forcato Massimiliano
Giovanetti Roberto
Verzini Massimo
Original Assignee
Zach System Spa
Fis Fabbrica Italiana Sintetici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zach System Spa, Fis Fabbrica Italiana Sintetici Spa filed Critical Zach System Spa
Publication of BRPI0919635A2 publication Critical patent/BRPI0919635A2/en
Publication of BRPI0919635A8 publication Critical patent/BRPI0919635A8/en
Publication of BRPI0919635B1 publication Critical patent/BRPI0919635B1/en
Publication of BRPI0919635B8 publication Critical patent/BRPI0919635B8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCESSO PARA PREPARAÇÃO DE CINACALCET. Trata-se de um processo para a preparação de N- [ (1R) - 1- (1-naftil) etil] -3- [3 (trifluorometil) -fenil] propan-1- amina da fórmula (I), isto é, Cinacalcet, e seus intermediários das fórmulas (V), (Va) e (Vb).PROCESS FOR PREPARING CINACALCET. This is a process for the preparation of N-[(1R)-1-(1-naphthyl)ethyl]-3-[3(trifluoromethyl)-phenyl]propan-1-amine of formula (I), i.e. , Cinacalcet, and their intermediates of formulas (V), (Va) and (Vb).

BRPI0919635A 2008-10-28 2009-10-16 process for preparing cinacalcet BRPI0919635B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08167762 2008-10-28
EP08167762.7 2008-10-28
PCT/EP2009/063603 WO2010049293A2 (en) 2008-10-28 2009-10-16 Process for preparing cinacalcet

Publications (4)

Publication Number Publication Date
BRPI0919635A2 BRPI0919635A2 (en) 2015-12-01
BRPI0919635A8 true BRPI0919635A8 (en) 2017-07-11
BRPI0919635B1 BRPI0919635B1 (en) 2021-03-09
BRPI0919635B8 BRPI0919635B8 (en) 2021-05-25

Family

ID=42041800

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0919635A BRPI0919635B8 (en) 2008-10-28 2009-10-16 process for preparing cinacalcet

Country Status (15)

Country Link
US (1) US8614353B2 (en)
EP (1) EP2358659B1 (en)
JP (1) JP5514218B2 (en)
CN (1) CN102159533B (en)
AU (1) AU2009309860B2 (en)
BR (1) BRPI0919635B8 (en)
CA (1) CA2734971C (en)
CY (1) CY1113722T1 (en)
ES (1) ES2401851T3 (en)
HR (1) HRP20130154T1 (en)
IL (1) IL211307A0 (en)
PL (1) PL2358659T3 (en)
PT (1) PT2358659E (en)
SI (1) SI2358659T1 (en)
WO (1) WO2010049293A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI1008294B1 (en) * 2009-02-19 2021-08-17 F.I.S. - Fabbrica Italiana Sintetici S.P.A METHOD FOR PREPARING CINACALCET HYDROCHLORIDE AND CINACALCET INTERMEDIATE
AU2010294283B2 (en) 2009-09-10 2016-09-29 F.I.S. - Fabbrica Italiana Sintetici S.P.A. Process for preparing Cinacalcet
CZ303627B6 (en) * 2011-11-25 2013-01-16 Zentiva, K.S. Process for preparing cinacalcet
CN103664577B (en) * 2012-09-06 2015-04-08 北京万生药业有限责任公司 Preparation method of cinacalcet intermediate
FR2995307A1 (en) 2012-09-07 2014-03-14 Prod Chim Auxiliaires Et De Synthese PROCESS FOR THE PREPARATION OF CINACALCET AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
CN106810452B (en) * 2017-01-13 2018-12-28 华北水利水电大学 A kind of preparation method of cinacalcet hydrochloride
CN106831441B (en) * 2017-01-23 2019-04-02 江苏康思尔医药科技有限公司 A kind of preparation method of cinacalcet hydrochloride

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2649616A1 (en) * 2006-04-27 2007-11-08 Teva Pharmaceutical Industries Ltd. Process for the preparation of cinacalcet base
EP1928817A1 (en) * 2006-04-27 2008-06-11 Teva Pharmaceutical Industries Ltd Process for the preparation of cinacalcet base
WO2008035381A2 (en) * 2006-09-22 2008-03-27 Ind-Swift Laboratories Limited Process for the preparation of amine derivatives as calcimimetics
WO2008117299A1 (en) * 2007-03-26 2008-10-02 Macleods Pharmaceuticals Limited Process for preparing cinacalcet hydrochloride

Also Published As

Publication number Publication date
ES2401851T3 (en) 2013-04-25
CA2734971C (en) 2017-01-31
WO2010049293A3 (en) 2010-10-21
JP5514218B2 (en) 2014-06-04
SI2358659T1 (en) 2013-04-30
US8614353B2 (en) 2013-12-24
EP2358659B1 (en) 2012-12-26
PL2358659T3 (en) 2013-06-28
CN102159533A (en) 2011-08-17
JP2012506847A (en) 2012-03-22
AU2009309860B2 (en) 2015-07-23
US20110207965A1 (en) 2011-08-25
EP2358659A2 (en) 2011-08-24
BRPI0919635B1 (en) 2021-03-09
BRPI0919635A2 (en) 2015-12-01
CN102159533B (en) 2014-08-27
CY1113722T1 (en) 2016-06-22
BRPI0919635B8 (en) 2021-05-25
AU2009309860A1 (en) 2010-05-06
HRP20130154T1 (en) 2013-03-31
CA2734971A1 (en) 2010-05-06
WO2010049293A2 (en) 2010-05-06
PT2358659E (en) 2013-03-28
IL211307A0 (en) 2011-04-28

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT)

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/03/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/10/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF