BRPI0817881A2 - Compostos orgânicos e seus usos - Google Patents

Compostos orgânicos e seus usos

Info

Publication number: BRPI0817881A2
Authority: BR; Brazil
Prior art keywords: organic compounds; compounds; organic
Prior art date: 2007-10-10

Application number

Other languages

English (en)

Inventor

Shawn D Britt

Lech Ciszewsky

Jiping Fu

Subramanian Karur

Yugang Liu

David Thomas Parker

Mahavir Prashad

Prakash Raman

Mohindra Seepersaud

Rui Zheng

Peichao Lu

Pascal Rigollier

Aregahegn Yifru

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-10

Filing date

2008-10-08

Publication date

2015-03-31

2008-10-08 Application filed by Novartis Ag filed Critical Novartis Ag

2015-03-31 Publication of BRPI0817881A2 publication Critical patent/BRPI0817881A2/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Virology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

BRPI0817881 2007-10-10 2008-10-08 Compostos orgânicos e seus usos BRPI0817881A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US97897407P	2007-10-10	2007-10-10
PCT/EP2008/063460 WO2009047264A1 (en)	2007-10-10	2008-10-08	Spiropyrrolidines and their use against hcv and hiv infection

Publications (1)

Publication Number	Publication Date
BRPI0817881A2 true BRPI0817881A2 (pt)	2015-03-31

Family

ID=40243948

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0817881 BRPI0817881A2 (pt)	2007-10-10	2008-10-08	Compostos orgânicos e seus usos

Country Status (20)

Country	Link
US (2)	US8008263B2 (pt)
EP (1)	EP2205584A1 (pt)
JP (1)	JP5095824B2 (pt)
KR (2)	KR101396696B1 (pt)
CN (2)	CN101868452B (pt)
AR (1)	AR068756A1 (pt)
AU (1)	AU2008309589B2 (pt)
BR (1)	BRPI0817881A2 (pt)
CA (1)	CA2702132A1 (pt)
CL (1)	CL2008002995A1 (pt)
CO (1)	CO6270317A2 (pt)
CR (1)	CR11310A (pt)
EA (1)	EA020951B1 (pt)
MA (1)	MA31767B1 (pt)
MX (1)	MX2010003916A (pt)
PE (1)	PE20091237A1 (pt)
TN (1)	TN2010000137A1 (pt)
TW (1)	TW200932737A (pt)
WO (1)	WO2009047264A1 (pt)
ZA (1)	ZA201001585B (pt)

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US20110182850A1 (en) *	2009-04-10	2011-07-28	Trixi Brandl	Organic compounds and their uses
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IN2014MN01547A (pt)	2012-02-10	2015-05-08	Lupin Ltd
CN103420991B (zh) *	2012-05-17	2017-07-07	乳源东阳光药业有限公司	作为丙型肝炎抑制剂的吡咯烷衍生物及其在药物中的应用
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WO2014070974A1 (en)	2012-11-05	2014-05-08	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
WO2014082379A1 (en) *	2012-11-29	2014-06-05	Sunshine Lake Pharma Co.,Ltd.	Spiro ring compound as hepatitis c virus (hcv) inhibitor and uses thereof field of the invention
TW201439084A (zh) *	2012-11-29	2014-10-16	Sunshine Lake Pharma Co Ltd	作爲丙型肝炎抑制劑的螺環化合物、藥物組合物及它們在藥物中的應用
WO2014082380A1 (en)	2012-11-29	2014-06-05	Sunshine Lake Pharma Co., Ltd.	Fused ring compounds as hepatitis c virus inhibitors, pharmaceutical compositions and uses thereof
US9580463B2 (en)	2013-03-07	2017-02-28	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
KR102178606B1 (ko)	2013-03-15	2020-11-13	자임워크스 인코포레이티드	세포독성 및 유사분열-억제 화합물, 및 이를 사용하는 방법
RU2729194C2 (ru)	2013-12-27	2020-08-05	Займворкс Инк.	Сульфонамидсодержащие связывающие системы для лекарственных конъюгатов
BR112016015105A8 (pt)	2013-12-27	2018-04-24	Var2 Pharmaceuticals Aps	conjugados var2csa-droga
CN104803989B (zh)	2014-01-23	2017-12-22	广东东阳光药业有限公司	作为丙型肝炎抑制剂的桥环化合物及其在药物中的应用
RU2723651C2 (ru)	2014-09-17	2020-06-17	Займворкс Инк.	Цитотоксические и антимитотические соединения и способы их применения
US11234977B2 (en)	2017-12-20	2022-02-01	Novartis Ag	Fused tricyclic pyrazolo-dihydropyrazinyl-pyridone compounds as antivirals
WO2022109360A1 (en)	2020-11-23	2022-05-27	Enanta Pharmaceuticals, Inc.	Novel spiropyrrolidine derived antiviral agents
WO2022140515A1 (en) *	2020-12-22	2022-06-30	The Regents Of The University Of California	Novel cyp3a4-specific inhibitors and methods of using same
WO2022235605A1 (en)	2021-05-04	2022-11-10	Enanta Pharmaceuticals, Inc.	Novel macrocyclic antiviral agents
US12398147B2 (en)	2021-05-11	2025-08-26	Enanta Pharmaceuticals, Inc.	Macrocyclic spiropyrrolidine derived antiviral agents
WO2023003610A1 (en) *	2021-07-23	2023-01-26	Enanta Pharmaceuticals, Inc.	Novel spiropyrrolidine derived antiviral agents
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2008
- 2008-10-08 AU AU2008309589A patent/AU2008309589B2/en not_active Ceased
- 2008-10-08 CN CN200880110944.7A patent/CN101868452B/zh not_active Expired - Fee Related
- 2008-10-08 EA EA201000556A patent/EA020951B1/ru not_active IP Right Cessation
- 2008-10-08 KR KR1020127015695A patent/KR101396696B1/ko not_active Expired - Fee Related
- 2008-10-08 KR KR1020107007789A patent/KR101218882B1/ko not_active Expired - Fee Related
- 2008-10-08 BR BRPI0817881 patent/BRPI0817881A2/pt not_active IP Right Cessation
- 2008-10-08 CA CA2702132A patent/CA2702132A1/en not_active Abandoned
- 2008-10-08 WO PCT/EP2008/063460 patent/WO2009047264A1/en not_active Ceased
- 2008-10-08 EP EP08805142A patent/EP2205584A1/en not_active Withdrawn
- 2008-10-08 MX MX2010003916A patent/MX2010003916A/es active IP Right Grant
- 2008-10-08 AR ARP080104396A patent/AR068756A1/es not_active Application Discontinuation
- 2008-10-08 CN CN201410273335.0A patent/CN104016970A/zh active Pending
- 2008-10-08 JP JP2010528385A patent/JP5095824B2/ja not_active Expired - Fee Related
- 2008-10-09 CL CL2008002995A patent/CL2008002995A1/es unknown
- 2008-10-09 TW TW097139071A patent/TW200932737A/zh unknown
- 2008-10-09 PE PE2008001744A patent/PE20091237A1/es not_active Application Discontinuation
- 2008-10-10 US US12/249,186 patent/US8008263B2/en not_active Expired - Fee Related
2010
- 2010-03-04 ZA ZA2010/01585A patent/ZA201001585B/en unknown
- 2010-03-11 CR CR11310A patent/CR11310A/es not_active Application Discontinuation
- 2010-03-26 TN TNP2010000137A patent/TN2010000137A1/fr unknown
- 2010-04-08 MA MA32757A patent/MA31767B1/fr unknown
- 2010-04-30 CO CO10051497A patent/CO6270317A2/es not_active Application Discontinuation
2011
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Also Published As

Publication number	Publication date
TN2010000137A1 (en)	2011-09-26
MA31767B1 (fr)	2010-10-01
CL2008002995A1 (es)	2009-06-26
PE20091237A1 (es)	2009-09-14
EA201000556A1 (ru)	2010-10-29
CN101868452A (zh)	2010-10-20
CN104016970A (zh)	2014-09-03
AR068756A1 (es)	2009-12-02
CO6270317A2 (es)	2011-04-20
KR101396696B1 (ko)	2014-05-16
AU2008309589B2 (en)	2012-07-05
CN101868452B (zh)	2014-08-06
KR20100051749A (ko)	2010-05-17
JP5095824B2 (ja)	2012-12-12
CA2702132A1 (en)	2009-04-16
US8222425B2 (en)	2012-07-17
WO2009047264A1 (en)	2009-04-16
AU2008309589A1 (en)	2009-04-16
TW200932737A (en)	2009-08-01
US20110275819A1 (en)	2011-11-10
CR11310A (es)	2010-05-06
MX2010003916A (es)	2010-05-05
US20090137495A1 (en)	2009-05-28
EA020951B1 (ru)	2015-03-31
JP2011500528A (ja)	2011-01-06
KR20120094049A (ko)	2012-08-23
ZA201001585B (en)	2010-12-29
EP2205584A1 (en)	2010-07-14
KR101218882B1 (ko)	2013-01-07
US8008263B2 (en)	2011-08-30

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