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BRPI0815708B8 - composto, éster de pró-droga, composição farmacêutica, e, método para tratar uma doença ou condição - Google Patents

composto, éster de pró-droga, composição farmacêutica, e, método para tratar uma doença ou condição

Info

Publication number
BRPI0815708B8
BRPI0815708B8 BRPI0815708A BRPI0815708A BRPI0815708B8 BR PI0815708 B8 BRPI0815708 B8 BR PI0815708B8 BR PI0815708 A BRPI0815708 A BR PI0815708A BR PI0815708 A BRPI0815708 A BR PI0815708A BR PI0815708 B8 BRPI0815708 B8 BR PI0815708B8
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
disease
treating
prodrug ester
Prior art date
Application number
BRPI0815708A
Other languages
English (en)
Inventor
Xu Baihua
Lv Binhua
Seed Brian
Wang Congna
Cheng Huawei
Y Roberge Jacques
Du Jiyan
J Hadd Michael
Li Shengbin
Feng Yan
Song Yanli
Chen Yuanwei
Wu Yuelin
Original Assignee
Theracos Sub Llc
Theracos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theracos Sub Llc, Theracos Inc filed Critical Theracos Sub Llc
Publication of BRPI0815708A2 publication Critical patent/BRPI0815708A2/pt
Publication of BRPI0815708A8 publication Critical patent/BRPI0815708A8/pt
Publication of BRPI0815708B1 publication Critical patent/BRPI0815708B1/pt
Publication of BRPI0815708B8 publication Critical patent/BRPI0815708B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

composto, éster de pró-droga, composição farmacêutica, e, uso de um composto fornecidos são compostos tendo um efeito inibitório sobre o cotransportador de glicose dependente de sódio sglt. a invenção também fornece composições farmacêuticas, métodos de preparar os compostos, intermediários sintéticos, e métodos de usar os compostos, independentemente ou em combinação com outros agentes terapêuticos, para tratar doenças e condições que são afetadas pela inibição de sglt.
BRPI0815708A 2007-08-23 2008-08-22 composto, éster de pró-droga, composição farmacêutica, e, método para tratar uma doença ou condição BRPI0815708B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95762507P 2007-08-23 2007-08-23
US60/957625 2007-08-23
PCT/US2008/074058 WO2009026537A1 (en) 2007-08-23 2008-08-22 Benzylbenzene derivatives and methods of use

Publications (4)

Publication Number Publication Date
BRPI0815708A2 BRPI0815708A2 (pt) 2014-09-30
BRPI0815708A8 BRPI0815708A8 (pt) 2019-04-09
BRPI0815708B1 BRPI0815708B1 (pt) 2019-07-02
BRPI0815708B8 true BRPI0815708B8 (pt) 2021-05-25

Family

ID=40378694

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815708A BRPI0815708B8 (pt) 2007-08-23 2008-08-22 composto, éster de pró-droga, composição farmacêutica, e, método para tratar uma doença ou condição

Country Status (30)

Country Link
US (4) US7838499B2 (pt)
EP (2) EP3318562A3 (pt)
JP (1) JP4809931B2 (pt)
KR (1) KR101107425B1 (pt)
CN (1) CN101790311B (pt)
AR (2) AR068016A1 (pt)
AU (1) AU2008288770B2 (pt)
BR (1) BRPI0815708B8 (pt)
CA (1) CA2697349C (pt)
CY (1) CY1119810T1 (pt)
DK (1) DK2187742T3 (pt)
ES (1) ES2654894T3 (pt)
HK (1) HK1254895A1 (pt)
HR (1) HRP20180127T1 (pt)
HU (1) HUE035947T2 (pt)
IL (1) IL203915A (pt)
LT (1) LT2187742T (pt)
MX (1) MX2010002027A (pt)
NO (1) NO2187742T3 (pt)
NZ (1) NZ583369A (pt)
PL (1) PL2187742T3 (pt)
PT (1) PT2187742T (pt)
RS (1) RS56822B1 (pt)
RU (1) RU2497526C2 (pt)
SG (1) SG188800A1 (pt)
SI (1) SI2187742T1 (pt)
TW (1) TWI434691B (pt)
UA (1) UA99924C2 (pt)
WO (1) WO2009026537A1 (pt)
ZA (1) ZA201001051B (pt)

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