BRPI0815092A2 - DUAL 5-HT2A AND D3 RECEIVER MODULATORS - Google Patents

DUAL 5-HT2A AND D3 RECEIVER MODULATORS

Info

Publication number: BRPI0815092A2
Authority: BR; Brazil
Prior art keywords: ht2a; dual; receiver modulators; modulators; receiver
Prior art date: 2007-07-26

Application number

BRPI0815092-3A2A

Other languages

Portuguese (pt)

Inventor

Luca Gobbi

Georg Jaeshke

Olivier Roche

Rosa Maria Rodrigues Sarmiento

Lucinda Steward

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-26

Filing date

2008-07-17

Publication date

2015-02-03

2008-07-17 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2015-02-03 Publication of BRPI0815092A2 publication Critical patent/BRPI0815092A2/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0815092-3A2A 2007-07-26 2008-07-17 DUAL 5-HT2A AND D3 RECEIVER MODULATORS BRPI0815092A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07113252		2007-07-26
PCT/EP2008/059356 WO2009013212A2 (en)	2007-07-26	2008-07-17	Dual modulators of 5-ht2a and d3 receptors

Publications (1)

Publication Number	Publication Date
BRPI0815092A2 true BRPI0815092A2 (en)	2015-02-03

Family

ID=40281888

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0815092-3A2A BRPI0815092A2 (en)	2007-07-26	2008-07-17	DUAL 5-HT2A AND D3 RECEIVER MODULATORS

Country Status (16)

Country	Link
US (4)	US20090029977A1 (en)
EP (1)	EP2183245B1 (en)
JP (1)	JP5502733B2 (en)
KR (1)	KR101169518B1 (en)
CN (1)	CN101778844B (en)
AR (1)	AR067662A1 (en)
AU (1)	AU2008280187B2 (en)
BR (1)	BRPI0815092A2 (en)
CA (1)	CA2694009A1 (en)
CL (1)	CL2008002162A1 (en)
ES (1)	ES2498673T3 (en)
PE (1)	PE20090892A1 (en)
RU (1)	RU2480466C2 (en)
TW (1)	TWI363623B (en)
WO (1)	WO2009013212A2 (en)
ZA (1)	ZA201000354B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2396265C2 (en) *	2006-02-17	2010-08-10	Ф. Хоффманн-Ля Рош Аг	Benzoylpiperidine derivatives as 5ht2 and d3 receptor modulators
AU2009294695B2 (en) *	2008-09-22	2012-09-13	F. Hoffmann-La Roche Ag	Piperazine D3 and 5-HT2a receptor modulators
KR20110076944A (en)	2008-09-23	2011-07-06	에프. 호프만-라 로슈 아게	Isoxazolo [4,5] pyridin-3-yl-piperazine derivatives useful as modulators of the dopamine D3 receptor
US8470828B2 (en) *	2010-07-06	2013-06-25	Hoffmann-La Roche Inc.	Anellated pyridine compounds
US8877778B2 (en) *	2010-12-15	2014-11-04	Hoffmann-La Roche Inc.	Benzofurane compounds
US8722683B2 (en) *	2011-02-17	2014-05-13	Hoffmann La-Roche Inc.	Benzodioxole piperazine compounds
US8598357B2 (en) *	2011-03-03	2013-12-03	Hoffmann-La Roche Inc.	Benzodioxole piperidine compounds
US8921397B2 (en) *	2011-05-04	2014-12-30	Hoffmann-La Roche Inc.	Benzofurane-piperidine compounds
CN105367565B (en) *	2014-08-20	2018-10-02	上海医药工业研究院	Piperazine (pyridine) cyclohexyl derivatives and its application for treating Mental disease
CN106518841B (en) *	2015-09-15	2019-03-05	浙江京新药业股份有限公司	Cyclohexane derivant or its stereoisomer or salt and its preparation and application
WO2017045599A1 (en) *	2015-09-15	2017-03-23	浙江京新药业股份有限公司	Cyclohexane derivative or stereoisomer or salt thereof, and preparation and use thereof
US10870660B2 (en)	2016-07-28	2020-12-22	Shionogi & Co., Ltd.	Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
CA3089498A1 (en)	2018-01-26	2019-08-01	Shionogi & Co., Ltd.	Condensed ring compounds having dopamine d3 receptor antagonistic effect
JP7250405B2 (en) *	2018-01-26	2023-04-03	塩野義製薬株式会社	Cyclic compound having dopamine D3 receptor antagonistic activity
MX2022004473A (en)	2019-10-29	2022-05-06	Shanghai Hansoh Biomedical Co Ltd	Modifier of four-membered ring derivative, preparation method and application thereof.
KR20220119013A (en)	2019-11-05	2022-08-26	상하이 한서 바이오메디컬 컴퍼니 리미티드	Benzothiophene derivative modulators, methods for their preparation and uses thereof
WO2021218863A1 (en) *	2020-04-26	2021-11-04	江苏恩华药业股份有限公司	1,5-dihydro-2,4-benzodiazepine-3-one derivative and application thereof
WO2022228447A1 (en)	2021-04-28	2022-11-03	上海翰森生物医药科技有限公司	Salt containing piperazine polycyclic derivative, crystal form thereof, preparation method therefor, and use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5364866A (en) *	1989-05-19	1994-11-15	Hoechst-Roussel Pharmaceuticals, Inc.	Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5776963A (en) *	1989-05-19	1998-07-07	Hoechst Marion Roussel, Inc.	3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
DK60693D0 (en) *	1993-05-26	1993-05-26	Novo Nordisk As	CHEMICAL COMPOUNDS, THEIR PREPARATION AND USE
BRPI9807312B8 (en)	1997-02-07	2016-09-13	Aventis Holdings Inc	(4-piperidinyl) -1h-2-benzopyran derivatives useful as antipsychotic agents, pharmaceutical composition and processes for preparing said derivatives
WO1999040067A2 (en) *	1998-02-09	1999-08-12	Duphar International Research B.V.	Benzisoxazole derivatives having d4-antagonistic activity
DE10010612A1 (en) *	2000-03-03	2001-09-27	Merck Patent Gmbh	Treatment of erectile dysfunction without inducing circulatory side-effects, using penis-specific phosphodiesterase V inhibitors, preferably benzo (4,5) thieno (2,3-d) pyrimidine derivatives
GB0117950D0 (en)	2001-02-16	2001-09-19	Aventis Pharma Inc	Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands
EP1632483B1 (en)	2001-02-16	2008-10-29	Aventis Pharmaceuticals Inc.	Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands
WO2002066469A2 (en)	2001-02-16	2002-08-29	Aventis Pharmaceuticals Inc.	Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands
GB0117577D0 (en) *	2001-02-16	2001-09-12	Aventis Pharm Prod Inc	Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
RU2396265C2 (en) *	2006-02-17	2010-08-10	Ф. Хоффманн-Ля Рош Аг	Benzoylpiperidine derivatives as 5ht2 and d3 receptor modulators
EP2079693B1 (en) *	2006-10-31	2013-02-27	F. Hoffmann-La Roche AG	Ether derivatives dual modulators of the 5-ht2a and d3 receptors
AU2008285729B2 (en) *	2007-08-09	2012-11-01	F. Hoffmann-La Roche Ag	Benzoyl-piperidine derivatives as dual modulators of the 5-HT2a and D3 receptors
AU2009294695B2 (en) *	2008-09-22	2012-09-13	F. Hoffmann-La Roche Ag	Piperazine D3 and 5-HT2a receptor modulators
EP2420558B1 (en) *	2010-08-17	2017-08-02	The Procter & Gamble Company	Stable sustainable hand dish-washing detergents
US8877778B2 (en) *	2010-12-15	2014-11-04	Hoffmann-La Roche Inc.	Benzofurane compounds

2008
- 2008-07-17 RU RU2010104631/04A patent/RU2480466C2/en not_active IP Right Cessation
- 2008-07-17 WO PCT/EP2008/059356 patent/WO2009013212A2/en not_active Ceased
- 2008-07-17 JP JP2010517368A patent/JP5502733B2/en not_active Expired - Fee Related
- 2008-07-17 ES ES08775170.7T patent/ES2498673T3/en active Active
- 2008-07-17 CA CA2694009A patent/CA2694009A1/en not_active Abandoned
- 2008-07-17 BR BRPI0815092-3A2A patent/BRPI0815092A2/en not_active IP Right Cessation
- 2008-07-17 CN CN2008800255361A patent/CN101778844B/en not_active Expired - Fee Related
- 2008-07-17 AU AU2008280187A patent/AU2008280187B2/en not_active Ceased
- 2008-07-17 EP EP08775170.7A patent/EP2183245B1/en not_active Not-in-force
- 2008-07-17 KR KR1020107004201A patent/KR101169518B1/en not_active Expired - Fee Related
- 2008-07-18 US US12/175,476 patent/US20090029977A1/en not_active Abandoned
- 2008-07-23 PE PE2008001250A patent/PE20090892A1/en not_active Application Discontinuation
- 2008-07-24 CL CL2008002162A patent/CL2008002162A1/en unknown
- 2008-07-24 AR ARP080103200A patent/AR067662A1/en not_active Application Discontinuation
- 2008-07-25 TW TW097128485A patent/TWI363623B/en not_active IP Right Cessation
2010
- 2010-01-18 ZA ZA201000354A patent/ZA201000354B/en unknown
2011
- 2011-10-25 US US13/280,523 patent/US20120040972A1/en not_active Abandoned
2013
- 2013-02-21 US US13/772,390 patent/US8829029B2/en not_active Expired - Fee Related
2014
- 2014-07-24 US US14/340,093 patent/US20140350051A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2010534632A (en)	2010-11-11
AU2008280187A1 (en)	2009-01-29
RU2480466C2 (en)	2013-04-27
US20130165432A1 (en)	2013-06-27
EP2183245B1 (en)	2014-07-09
WO2009013212A3 (en)	2009-06-11
CA2694009A1 (en)	2009-01-29
US20120040972A1 (en)	2012-02-16
PE20090892A1 (en)	2009-07-13
TW200911236A (en)	2009-03-16
US20090029977A1 (en)	2009-01-29
AR067662A1 (en)	2009-10-21
US20140350051A1 (en)	2014-11-27
KR101169518B1 (en)	2012-07-27
WO2009013212A2 (en)	2009-01-29
US8829029B2 (en)	2014-09-09
TWI363623B (en)	2012-05-11
JP5502733B2 (en)	2014-05-28
AU2008280187B2 (en)	2013-05-16
CN101778844B (en)	2013-01-02
ES2498673T3 (en)	2014-09-25
RU2010104631A (en)	2011-09-10
CL2008002162A1 (en)	2009-05-29
CN101778844A (en)	2010-07-14
EP2183245A2 (en)	2010-05-12
KR20100036384A (en)	2010-04-07
ZA201000354B (en)	2010-10-27

Publication	Publication Date	Title
BRPI0815092A2 (en)	2015-02-03	DUAL 5-HT2A AND D3 RECEIVER MODULATORS
CR10930A (en)	2013-02-12	ACETILCOLINE NICOTINIC RECEIVER MODULATORS
EP2173040A4 (en)	2014-07-23	MONOPORT SIGNAL REPEATER
EP2051523A4 (en)	2011-06-15	RECEIVER
BRPI0818380A2 (en)	2014-10-07	HERBICIDE-PROTECTOR COMBINATION
BRPI0903496A2 (en)	2015-06-23	Transmitting and receiving devices.
EP2033391A4 (en)	2010-09-29	ALTBOC RECEIVER
BRPI0921327A2 (en)	2015-08-25	Herbicide-Protector Combination
EP2333393A4 (en)	2011-08-24	JOINT UNIT
BRPI0820978A2 (en)	2015-06-16	Communication of visual change content
GB2452361B (en)	2010-09-22	Optical time domain refectometry
EP3270564C0 (en)	2024-04-10	DISTRIBUTED SECURITY PROVISION
EP2124523A4 (en)	2010-08-04	LINE OF LITTLE P2428-5006090
BRPI0918949A2 (en)	2019-09-24	5-ht2a and piperazine d3 receptor modulators
BRPI0908821A2 (en)	2015-07-28	Power-sharing hydrostatic transmission
EP2192831A4 (en)	2012-12-19	CUPPER-TRAINER SLEEVE
ITMI20072422A1 (en)	2008-06-27	OPTICAL RECEIVER
EP2153565A4 (en)	2015-03-18	TRANSMISSION MODE SELECTION
EP2116533A4 (en)	2012-01-25	GLUCOKINASE ACTIVATOR
BRPI0921058A2 (en)	2018-10-16	dihydrotetraazabenzoazulenes alkylcyclohexyl ethers
BRPI0811115A2 (en)	2014-12-23	PYRIMIDONE HYPEREROYLAMIDE
EP2218202A4 (en)	2012-10-24	IMPROVED CONFLICT-BASED COMMUNICATION
EP2304494A4 (en)	2012-02-22	BACKLIGHT UNIT
EP2309690A4 (en)	2016-04-20	MDF RECEIVER
BRPI0922728A2 (en)	2019-09-24	herbicide-antidote combination

Legal Events

Date	Code	Title	Description
2017-05-23	B08F	Application fees: dismissal - article 86 of industrial property law
2017-09-05	B08K	Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)