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BRPI0814558A2 - Métodos para aagerar resposta imune usando liberação de ácido nucléico mediada por lipossoma catiônico - Google Patents

Métodos para aagerar resposta imune usando liberação de ácido nucléico mediada por lipossoma catiônico

Info

Publication number
BRPI0814558A2
BRPI0814558A2 BRPI0814558-0A2A BRPI0814558A BRPI0814558A2 BR PI0814558 A2 BRPI0814558 A2 BR PI0814558A2 BR PI0814558 A BRPI0814558 A BR PI0814558A BR PI0814558 A2 BRPI0814558 A2 BR PI0814558A2
Authority
BR
Brazil
Prior art keywords
liposoma
cationic
methods
nucleic acid
immune response
Prior art date
Application number
BRPI0814558-0A2A
Other languages
English (en)
Inventor
Esther H Chang
Kathleen F Pirollo
Original Assignee
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown filed Critical Univ Georgetown
Publication of BRPI0814558A2 publication Critical patent/BRPI0814558A2/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins

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BRPI0814558-0A2A 2007-07-09 2008-07-09 Métodos para aagerar resposta imune usando liberação de ácido nucléico mediada por lipossoma catiônico BRPI0814558A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92968507P 2007-07-09 2007-07-09
PCT/US2008/008394 WO2009009054A1 (en) 2007-07-09 2008-07-09 Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery

Publications (1)

Publication Number Publication Date
BRPI0814558A2 true BRPI0814558A2 (pt) 2015-01-06

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ID=40228915

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Application Number Title Priority Date Filing Date
BRPI0814558-0A2A BRPI0814558A2 (pt) 2007-07-09 2008-07-09 Métodos para aagerar resposta imune usando liberação de ácido nucléico mediada por lipossoma catiônico

Country Status (15)

Country Link
US (1) US20090053299A1 (pt)
EP (1) EP2175835B1 (pt)
JP (2) JP5890095B2 (pt)
KR (2) KR101570886B1 (pt)
CN (2) CN106890142A (pt)
AU (1) AU2008275713B2 (pt)
BR (1) BRPI0814558A2 (pt)
CA (1) CA2692546C (pt)
EA (1) EA201070050A1 (pt)
IL (1) IL203204B (pt)
MX (1) MX2010000166A (pt)
NZ (1) NZ582414A (pt)
SG (1) SG182994A1 (pt)
WO (1) WO2009009054A1 (pt)
ZA (1) ZA201000038B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5573111B2 (ja) * 2009-11-06 2014-08-20 ライオン株式会社 イソプロピルメチルフェノール含有液体口腔用組成物
US20110182976A1 (en) * 2010-01-28 2011-07-28 National Taiwan Ocean University Lipoplex-patch based dna vaccine
WO2011105520A1 (ja) * 2010-02-26 2011-09-01 国立大学法人 長崎大学 抗原または薬物送達複合体
EP4043040B1 (en) * 2010-08-31 2023-01-11 GlaxoSmithKline Biologicals SA Small liposomes for delivery of immunogen-encoding rna
WO2012040101A1 (en) 2010-09-21 2012-03-29 University Of Miami Compositions and methods for inducing migration by dendritic cells and an immune response
WO2012040266A2 (en) * 2010-09-24 2012-03-29 University Of Miami Gene-based adjuvants and compositions thereof to increase antibody production in response to gene-based vaccines
KR20140038288A (ko) * 2012-09-19 2014-03-28 조지타운 유니버시티 표적화된 리포솜
US20140120157A1 (en) 2012-09-19 2014-05-01 Georgetown University Targeted liposomes
CN103405386B (zh) * 2012-09-21 2016-05-18 上海泽润生物科技有限公司 一种脂质体的制备方法及制作脂质体佐剂的方法
CA2901616A1 (en) * 2013-03-14 2014-10-02 Georgetown University Treatment for exposure to nerve agent
CN105726485B (zh) * 2016-03-24 2019-08-06 东华大学 一种半乳糖化壳聚糖修饰的免疫醇质体的制备方法
WO2020117715A1 (en) 2018-12-03 2020-06-11 Board Of Regents, The University Of Texas System Oligo-benzamide analogs and their use in cancer treatment
CN111840538A (zh) * 2020-05-29 2020-10-30 中山大学 一种水痘-带状疱疹病毒亚单位纳米疫苗的制备方法和应用
CN117883382B (zh) * 2023-11-27 2025-02-14 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 高效递送疫苗的脂质体载体及脂质体疫苗的制备与用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957735A (en) * 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5688488A (en) * 1989-04-03 1997-11-18 Purdue Research Foundation Composition and method for tumor imaging
US5753258A (en) * 1990-10-19 1998-05-19 University Of Florida Artificial viral envelopes
US6099842A (en) * 1990-12-03 2000-08-08 The United States Of America As Represented By The Department Of Health And Human Services Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin receptor and diptheria toxin
EP0671926B1 (en) * 1992-08-11 2002-11-13 President And Fellows Of Harvard College Immunomodulatory peptides
US5786214A (en) * 1994-12-15 1998-07-28 Spinal Cord Society pH-sensitive immunoliposomes and method of gene delivery to the mammalian central nervous system
FR2730637B1 (fr) * 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
AU6113396A (en) * 1995-06-14 1997-01-15 Regents Of The University Of California, The Novel high affinity human antibodies to tumor antigens
US6210707B1 (en) * 1996-11-12 2001-04-03 The Regents Of The University Of California Methods of forming protein-linked lipidic microparticles, and compositions thereof
CA2271325A1 (en) * 1996-11-12 1998-05-22 The Regents Of The University Of California Preparation of stable formulations of lipid-nucleic acid complexes for efficient in vivo delivery
US6794128B2 (en) * 1998-04-24 2004-09-21 The Regents Of The University Of California Methods of selecting internalizing antibodies
US20030022854A1 (en) * 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
PT1811036E (pt) 1999-02-22 2011-07-11 Univ Georgetown Imunolipossomas dirigidos por fragmento de anticorpo para distribuição sistémica de genes
US9034329B2 (en) * 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
US20020103165A1 (en) * 2000-02-29 2002-08-01 Alliance Pharmaceutical Corp., Engineered spray-dried lipid-based microparticles for cellular targeting
CN1798545B (zh) 2003-06-04 2013-06-05 乔治敦大学 改良脂质体复合物的稳定性和保存期的方法
KR20080064169A (ko) * 2005-10-20 2008-07-08 조지타운 유니버시티 암의 초기 ｍｒｉ 검출을 개선하기 위한 종양-표적화나노전달 시스템

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CN106890142A (zh) 2017-06-27
AU2008275713A1 (en) 2009-01-15
EP2175835A1 (en) 2010-04-21
CA2692546C (en) 2018-03-13
IL203204B (en) 2018-05-31
EA201070050A1 (ru) 2010-10-29
US20090053299A1 (en) 2009-02-26
NZ582414A (en) 2012-09-28
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MX2010000166A (es) 2010-04-27
KR101570886B1 (ko) 2015-11-23
KR20100044206A (ko) 2010-04-29
JP2014148533A (ja) 2014-08-21
WO2009009054A1 (en) 2009-01-15
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CA2692546A1 (en) 2009-01-15
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AU2008275713B2 (en) 2014-08-07

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