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BRPI0814097A2 - Derivado do peptídeo insulinotrópico cm seu aminoácido n-terminal modificado - Google Patents

Derivado do peptídeo insulinotrópico cm seu aminoácido n-terminal modificado

Info

Publication number
BRPI0814097A2
BRPI0814097A2 BRPI0814097-9A2A BRPI0814097A BRPI0814097A2 BR PI0814097 A2 BRPI0814097 A2 BR PI0814097A2 BR PI0814097 A BRPI0814097 A BR PI0814097A BR PI0814097 A2 BRPI0814097 A2 BR PI0814097A2
Authority
BR
Brazil
Prior art keywords
modified
amino acid
terminal amino
peptide derivative
insulinotropic peptide
Prior art date
Application number
BRPI0814097-9A2A
Other languages
English (en)
Inventor
Dae Hae Song
Chang Ki Lim
Young Hoon Kim
Se Chang Kwon
Gwan Sun Lee
Sung Min Bae
Sung Youb Jung
Original Assignee
Hanmi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharmaceutical Co Ltd filed Critical Hanmi Pharmaceutical Co Ltd
Publication of BRPI0814097A2 publication Critical patent/BRPI0814097A2/pt
Publication of BRPI0814097A8 publication Critical patent/BRPI0814097A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
BRPI0814097A 2007-07-16 2008-07-16 Derivado do peptídeo insulinotrópico cm seu aminoácido n-terminal modificado BRPI0814097A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20070071071 2007-07-16
EP60991155 2007-11-29
PCT/KR2008/004170 WO2009011544A2 (en) 2007-07-16 2008-07-16 Insulinotropic peptide derivative wherein its n-terminal amino acid is modified

Publications (2)

Publication Number Publication Date
BRPI0814097A2 true BRPI0814097A2 (pt) 2015-02-03
BRPI0814097A8 BRPI0814097A8 (pt) 2016-01-12

Family

ID=40260219

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814097A BRPI0814097A8 (pt) 2007-07-16 2008-07-16 Derivado do peptídeo insulinotrópico cm seu aminoácido n-terminal modificado

Country Status (21)

Country Link
US (1) US9422349B2 (pt)
EP (4) EP2537861B1 (pt)
JP (7) JP2009019027A (pt)
KR (1) KR101231431B1 (pt)
CN (2) CN101778863A (pt)
AR (1) AR067555A1 (pt)
AU (1) AU2008276762A1 (pt)
BR (1) BRPI0814097A8 (pt)
CA (3) CA2789112C (pt)
DK (1) DK2390265T3 (pt)
ES (3) ES2444622T3 (pt)
IL (1) IL203288A (pt)
MY (1) MY167486A (pt)
NZ (3) NZ594853A (pt)
PH (2) PH12014500922A1 (pt)
PT (1) PT2390265E (pt)
RU (1) RU2442792C2 (pt)
SG (3) SG10201510249PA (pt)
TW (3) TWI454276B (pt)
WO (1) WO2009011544A2 (pt)
ZA (1) ZA201000125B (pt)

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JP2009019027A (ja) * 2007-07-16 2009-01-29 Hanmi Pharmaceutical Co Ltd アミノ末端のアミノ酸が変異したインスリン分泌ペプチド誘導体
DK2408800T3 (en) 2009-03-20 2016-08-29 Hanmi Science Co Ltd A process for the preparation of a site-specific conjugate of a physiologically active polypeptide
KR20120116942A (ko) 2009-11-23 2012-10-23 아밀린 파마슈티칼스, 인크. 폴리펩티드 접합체
RU2422461C1 (ru) * 2010-02-09 2011-06-27 Федеральное государственное образовательное учреждение высшего профессионального образования Санкт-Петербургский государственный университет Аналоги эксенатида
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JP6006309B2 (ja) 2011-07-08 2016-10-12 アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc 作用持続期間が増大し、免疫原性が減少した操作されたポリペプチド
KR20130049671A (ko) 2011-11-04 2013-05-14 한미사이언스 주식회사 생리활성 폴리펩타이드 결합체 제조 방법
AR090281A1 (es) 2012-03-08 2014-10-29 Hanmi Science Co Ltd Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo
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US10441665B2 (en) 2012-07-25 2019-10-15 Hanmi Pharm. Co., Ltd. Liquid formulation of long acting insulinotropic peptide conjugate
AR094821A1 (es) 2012-07-25 2015-09-02 Hanmi Pharm Ind Co Ltd Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada
AR092862A1 (es) 2012-07-25 2015-05-06 Hanmi Pharm Ind Co Ltd Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion
KR20140088837A (ko) * 2013-01-03 2014-07-11 한미약품 주식회사 Ｎ-말단 전하가 변형된 인슐린 분비 펩티드 유도체
AR096891A1 (es) 2013-07-12 2016-02-03 Hanmi Pharm Ind Co Ltd Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo
AR096890A1 (es) 2013-07-12 2016-02-03 Hanmi Pharm Ind Co Ltd Conjugando fc de inmunoglobulina, que mantiene la afinidad de unión del fragmento fc de la inmunoglobulina a fcrn
PE20161153A1 (es) 2014-01-20 2016-10-27 Hanmi Pharm Ind Co Ltd Insulina de accion prolongada y uso de la misma
EP4464332A1 (en) 2014-03-31 2024-11-20 Hanmi Pharm. Co., Ltd. Composition for improving the solubility of a protein or peptide by using immunoglobulin fc fragment linkage
AR100639A1 (es) 2014-05-29 2016-10-19 Hanmi Pharm Ind Co Ltd Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada
TWI684458B (zh) 2014-05-30 2020-02-11 南韓商韓美藥品股份有限公司 包含胰島素及ｇｌｐ-１/昇糖素雙重促效劑之治療糖尿病之組成物
EP3325496B1 (en) 2015-07-24 2024-02-07 Hanmi Pharm. Co., Ltd. Method of preparing physiologically active polypeptide conjugate
UY36870A (es) 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos
WO2017075505A2 (en) * 2015-10-28 2017-05-04 Tufts University Novel polypeptides with improved proteolytic stability, and methods of preparing and using same
RU2764197C1 (ru) 2016-09-23 2022-01-14 Ханми Фарм. Ко., Лтд. Аналоги инсулина с пониженной аффинностью к рецептору инсулина и их применение
WO2018105988A1 (ko) 2016-12-05 2018-06-14 한미약품 주식회사 면역반응이 약화된 결합체
WO2018143729A1 (ko) 2017-02-03 2018-08-09 한미약품 주식회사 지속성이 증가된 생리활성 물질의 결합체 및 이의 용도
WO2018174668A2 (ko) 2017-03-23 2018-09-27 한미약품 주식회사 인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도
AU2021409610A1 (en) * 2020-12-24 2023-07-06 Hanmi Pharm. Co., Ltd. Combination therapy of insulinotropic peptide and glp-2, for preventing or treating short bowel syndrome
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KR20230000682A (ko) 2021-06-25 2023-01-03 한미약품 주식회사 심혈관 질환 또는 신장 기능장애 발생의 위험을 감소시키기 위한 에페글레나타이드
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Also Published As

Publication number Publication date
WO2009011544A2 (en) 2009-01-22
MY167486A (en) 2018-08-30
ES2528346T3 (es) 2015-02-09
JP5481377B2 (ja) 2014-04-23
EP2390265A3 (en) 2012-03-21
ZA201000125B (en) 2011-04-28
CA2693154A1 (en) 2009-01-22
EP2537861B1 (en) 2014-11-26
TW200922615A (en) 2009-06-01
JP2015172058A (ja) 2015-10-01
CN104672319B (zh) 2020-03-10
TWI532496B (zh) 2016-05-11
EP2176289A2 (en) 2010-04-21
US9422349B2 (en) 2016-08-23
NZ596828A (en) 2012-03-30
EP2537860A1 (en) 2012-12-26
JP2013014598A (ja) 2013-01-24
SG183033A1 (en) 2012-08-30
CN101778863A (zh) 2010-07-14
TW201311273A (zh) 2013-03-16
NZ582471A (en) 2012-01-12
EP2537860B1 (en) 2014-11-26
JP2009019027A (ja) 2009-01-29
JP2015166368A (ja) 2015-09-24
JP2014094948A (ja) 2014-05-22
SG10201510245SA (en) 2016-01-28
PH12014500923A1 (en) 2016-03-07
HK1207088A1 (en) 2016-01-22
US20100204451A1 (en) 2010-08-12
ES2444622T3 (es) 2014-02-26
CA2789112C (en) 2015-01-20
NZ594853A (en) 2012-03-30
CN104672319A (zh) 2015-06-03
TWI524896B (zh) 2016-03-11
DK2390265T3 (da) 2014-02-10
AU2008276762A1 (en) 2009-01-22
EP2390265B1 (en) 2013-11-06
EP2176289A4 (en) 2010-10-27
WO2009011544A3 (en) 2009-03-19
CA2789123C (en) 2015-01-06
JP2010533709A (ja) 2010-10-28
AR067555A1 (es) 2009-10-14
KR20090008151A (ko) 2009-01-21
KR101231431B1 (ko) 2013-02-07
SG10201510249PA (en) 2016-01-28
BRPI0814097A8 (pt) 2016-01-12
RU2442792C2 (ru) 2012-02-20
RU2010101232A (ru) 2011-07-27
CA2693154C (en) 2014-09-09
EP2537861A1 (en) 2012-12-26
JP6023515B2 (ja) 2016-11-09
EP2390265A2 (en) 2011-11-30
TWI454276B (zh) 2014-10-01
PT2390265E (pt) 2014-02-12
ES2528347T3 (es) 2015-02-09
JP6023516B2 (ja) 2016-11-09
TW201311272A (zh) 2013-03-16
CA2789123A1 (en) 2009-01-22
IL203288A (en) 2016-02-29
PH12014500922A1 (en) 2016-03-07
CA2789112A1 (en) 2009-01-22
JP2013010779A (ja) 2013-01-17

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