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BRPI0606659A2 - processos para a preparação de álcoois aminoetoxibenzìlicos - Google Patents

processos para a preparação de álcoois aminoetoxibenzìlicos

Info

Publication number
BRPI0606659A2
BRPI0606659A2 BRPI0606659-3A BRPI0606659A BRPI0606659A2 BR PI0606659 A2 BRPI0606659 A2 BR PI0606659A2 BR PI0606659 A BRPI0606659 A BR PI0606659A BR PI0606659 A2 BRPI0606659 A2 BR PI0606659A2
Authority
BR
Brazil
Prior art keywords
processes
preparation
alcohols
aminoethoxybenzyl
aminoethoxybenzyl alcohols
Prior art date
Application number
BRPI0606659-3A
Other languages
English (en)
Inventor
Pietro Allegrini
Giuseppe Barreca
Giorgio Soriato
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0606659A2 publication Critical patent/BRPI0606659A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

PROCESSOS PARA A PREPARAçãO DE áLCOOIS AMINOETOXIBENZìLICOS. A presente invenção refere-se a processos e intermediários para a preparação de álcoois aminoetoxibenzílicos de fórmula (1) úteis na produção de compostos farmaceuticamente úteis.
BRPI0606659-3A 2005-01-13 2006-01-11 processos para a preparação de álcoois aminoetoxibenzìlicos BRPI0606659A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64350505P 2005-01-13 2005-01-13
PCT/US2006/000801 WO2006076350A2 (en) 2005-01-13 2006-01-11 Processes for the preparation of aminoethoxybenzyl alcohols

Publications (1)

Publication Number Publication Date
BRPI0606659A2 true BRPI0606659A2 (pt) 2009-07-07

Family

ID=36570630

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606659-3A BRPI0606659A2 (pt) 2005-01-13 2006-01-11 processos para a preparação de álcoois aminoetoxibenzìlicos

Country Status (21)

Country Link
US (2) US7375251B2 (pt)
EP (1) EP1836155A2 (pt)
JP (1) JP2008526969A (pt)
KR (1) KR20070097502A (pt)
CN (1) CN101107217A (pt)
AR (1) AR055837A1 (pt)
AU (1) AU2006205099A1 (pt)
BR (1) BRPI0606659A2 (pt)
CA (1) CA2593965A1 (pt)
CR (1) CR9208A (pt)
GT (1) GT200600010A (pt)
IL (1) IL184193A0 (pt)
MX (1) MX2007008450A (pt)
NI (1) NI200700175A (pt)
NO (1) NO20073276L (pt)
PA (1) PA8659601A1 (pt)
PE (1) PE20060874A1 (pt)
RU (1) RU2007124069A (pt)
SG (1) SG158860A1 (pt)
TW (1) TW200637803A (pt)
WO (1) WO2006076350A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102395561A (zh) 2009-04-13 2012-03-28 桑多斯股份公司 合成巴多昔芬乙酸酯及其中间体的方法
EP2794580A1 (en) * 2011-12-23 2014-10-29 Basf Se Process for manufacturing benzoxazinones
BR112015002464B8 (pt) * 2012-08-17 2020-04-22 Basf Se processo para a preparação de carbamat-benzoxazinona, carbamat-benzoxazinona e uso da carbamat-benzoxazinona
BR112017028448A2 (pt) 2015-07-02 2018-08-28 Horizon Orphan Llc análogos de cisteamina resistentes a ado e usos dos mesmos
CN107793344B (zh) * 2017-10-24 2021-01-12 扬子江药业集团有限公司 一种醋酸巴多昔芬的工业化生产方法
CN113816892A (zh) * 2021-08-27 2021-12-21 安徽鼎旺医药有限公司 一种醋酸巴多昔芬的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH543472A (fr) * 1969-01-31 1973-10-31 Orchimed Sa Procédé pour la préparation d'acides phénoxyalcoyl-carboxyliques
DE2003430C3 (de) * 1969-01-31 1978-12-07 Laboratorien Fournier Gmbh, 6600 Saarbruecken p-Benzoylphenoxyisobuttersäureester, ihre Herstellung und diese enthaltende Arzneimittel
US3772356A (en) * 1970-03-26 1973-11-13 Lab Bruneau & Cie Phenoxy-acetamides
GB8919434D0 (en) * 1989-08-25 1989-10-11 Beecham Group Plc Novel compounds
DE4438028A1 (de) 1994-10-25 1996-05-02 Thomae Gmbh Dr K Basisch substituierte N-Phenylalkyl- und N-Phenoxyalkylamide, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
US5998402A (en) 1996-04-19 1999-12-07 American Home Products Corporation 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
US5929097A (en) 1996-10-16 1999-07-27 American Cyanamid Company Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US6005102A (en) 1997-10-15 1999-12-21 American Home Products Corporation Aryloxy-alkyl-dialkylamines
EE200000225A (et) * 1997-10-15 2001-06-15 American Home Products Corporation Arüüloksüalküüldialküülamiinid, nende valmistamismeetodid ja farmatseutiline kompositsioon
DE10146867A1 (de) * 2001-09-24 2003-04-24 Bayer Ag Tetrahydroisochinoline
EP1597256A1 (en) * 2003-02-21 2005-11-23 Pfizer Inc. N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors

Also Published As

Publication number Publication date
PA8659601A1 (es) 2007-01-17
NI200700175A (es) 2008-05-09
NO20073276L (no) 2007-09-04
CR9208A (es) 2007-10-23
US7375251B2 (en) 2008-05-20
MX2007008450A (es) 2007-08-06
US20080207898A1 (en) 2008-08-28
WO2006076350A2 (en) 2006-07-20
KR20070097502A (ko) 2007-10-04
PE20060874A1 (es) 2006-10-16
CA2593965A1 (en) 2006-07-20
TW200637803A (en) 2006-11-01
JP2008526969A (ja) 2008-07-24
US20060155147A1 (en) 2006-07-13
WO2006076350A3 (en) 2007-03-01
CN101107217A (zh) 2008-01-16
IL184193A0 (en) 2007-10-31
EP1836155A2 (en) 2007-09-26
AU2006205099A1 (en) 2006-07-20
SG158860A1 (en) 2010-02-26
AR055837A1 (es) 2007-09-12
RU2007124069A (ru) 2009-02-20
GT200600010A (es) 2006-08-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE A DESPACHO 8.6 NA RPI 2161 DE 05/06/2012.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2165 DE 03/07/2012.