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BRPI0512378A - método para clarificação de amostra de célula em escala industrial - Google Patents

método para clarificação de amostra de célula em escala industrial

Info

Publication number
BRPI0512378A
BRPI0512378A BRPI0512378-0A BRPI0512378A BRPI0512378A BR PI0512378 A BRPI0512378 A BR PI0512378A BR PI0512378 A BRPI0512378 A BR PI0512378A BR PI0512378 A BRPI0512378 A BR PI0512378A
Authority
BR
Brazil
Prior art keywords
industrial scale
cell sample
scale cell
clarification method
sample clarification
Prior art date
Application number
BRPI0512378-0A
Other languages
English (en)
Inventor
Christine Y Pham
J Rg Th Mmes
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35784204&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0512378(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of BRPI0512378A publication Critical patent/BRPI0512378A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/803—Physical recovery methods, e.g. chromatography, grinding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Water Supply & Treatment (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Centrifugal Separators (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

MéTODO PARA CLARIFICAçãO DE AMOSTRA DE CéLULA EM ESCALA INDUSTRIAL. A presente invenção refere-se a métodos para clarificação de amostras celulares empregando-se centrifugação em combinação com filtração profunda.
BRPI0512378-0A 2004-06-21 2005-06-21 método para clarificação de amostra de célula em escala industrial BRPI0512378A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/871,261 US7157276B2 (en) 2003-06-20 2004-06-21 Use of depth filtration in series with continuous centrifugation to clarify mammalian cell cultures
PCT/US2005/021781 WO2006007459A1 (en) 2004-06-21 2005-06-21 Use of depth filtration in series with continuous centrifugation to clarify mammalian cell cultures

Publications (1)

Publication Number Publication Date
BRPI0512378A true BRPI0512378A (pt) 2008-03-11

Family

ID=35784204

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512378-0A BRPI0512378A (pt) 2004-06-21 2005-06-21 método para clarificação de amostra de célula em escala industrial

Country Status (19)

Country Link
US (2) US7157276B2 (pt)
EP (1) EP1776174A4 (pt)
JP (1) JP2008503218A (pt)
KR (1) KR20070046818A (pt)
CN (1) CN100531868C (pt)
AU (1) AU2005262431A1 (pt)
BR (1) BRPI0512378A (pt)
CA (1) CA2572181A1 (pt)
CZ (1) CZ2006822A3 (pt)
EA (1) EA011353B1 (pt)
GE (1) GEP20094715B (pt)
IL (1) IL180173A0 (pt)
IS (1) IS8582A (pt)
MX (1) MXPA06014891A (pt)
NO (1) NO20070386L (pt)
PL (1) PL382304A1 (pt)
RS (1) RS20060680A (pt)
WO (1) WO2006007459A1 (pt)
ZA (1) ZA200700180B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7157276B2 (en) 2003-06-20 2007-01-02 Biogen Idec Inc. Use of depth filtration in series with continuous centrifugation to clarify mammalian cell cultures
US9222067B2 (en) * 2008-04-22 2015-12-29 Pneumatic Scale Corporation Single use centrifuge system for highly concentrated and/or turbid feeds
US20110184154A1 (en) * 2008-10-17 2011-07-28 Percivia Llc Cell broth clarification and host cell protein removal
ES2480268T3 (es) * 2010-02-25 2014-07-25 Alfa Laval Corporate Ab Equipo de limpieza para fluido de lavado químico de gases
EP2402288B1 (en) * 2010-07-02 2016-11-16 Alfa Laval Corporate AB Cleaning equipment for gas scrubber fluid
BR112012019037A2 (pt) 2010-02-25 2018-03-13 Alfa Laval Corp Ab equipamento de limpeza de gás de escapamento para um motor diesel , e, método para limpar fluido de purificador poluído
BR112012024628A2 (pt) * 2010-04-02 2016-06-07 Pneumatic Scale Corp método e sistema de centrífuga
US20140324360A1 (en) * 2011-09-21 2014-10-30 Millennium Pharmaceuticals, Inc. Anti-gcc antibody molecules and related compositions and methods
US9556412B2 (en) 2012-04-17 2017-01-31 Regents Of The University Of Minnesota Inlet and outlet geometries for a vertical three-stream microfluidic device
US8911634B2 (en) * 2012-08-07 2014-12-16 Molecular Devices, Llc Apparatus and method for separating materials of different densities
RU2768003C2 (ru) 2013-03-08 2022-03-22 Джензим Корпорейшн Интегрированное непрерывное производство терапевтических белковых лекарственных веществ
NZ756750A (en) 2013-09-13 2022-05-27 Genentech Inc Methods and compositions comprising purified recombinant polypeptides
ES2915378T3 (es) 2013-09-13 2022-06-22 Hoffmann La Roche Procedimientos para detectar y cuantificar una proteína de célula huésped en líneas celulares
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
EP3119871A4 (en) * 2014-03-17 2018-01-03 Regeneron Pharmaceuticals, Inc. Clarification of mammalian cell culture
WO2017027861A1 (en) 2015-08-13 2017-02-16 Amgen Inc. Charged depth filtration of antigen-binding proteins
RU2751919C2 (ru) * 2016-03-29 2021-07-20 Басф Се Способ получения раствора полиакриламида с увеличенной вязкостью
CN108624499A (zh) * 2017-12-18 2018-10-09 佛山安普泽生物医药股份有限公司 一种哺乳动物细胞大规模生产培养方法
HK40046210A (en) 2018-08-31 2021-10-29 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
CN113286804A (zh) * 2018-12-21 2021-08-20 伊克诺斯科学公司 细胞培养物澄清的方法
GB201904083D0 (en) * 2019-03-25 2019-05-08 Ge Healthcare Bio Sciences Ab A bioreactor system
WO2021150996A1 (en) * 2020-01-24 2021-07-29 Amgen Inc. Methods for harvesting biomolecules
EP3936601A1 (en) * 2020-07-06 2022-01-12 Sartorius Stedim Biotech GmbH Clarification setup of a bioprocessing installation
KR102621026B1 (ko) * 2021-10-15 2024-01-09 에스케이바이오사이언스(주) 단백질의 정제방법
CN115466303A (zh) * 2022-09-15 2022-12-13 无锡药明生物技术股份有限公司 一种澄清处理的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0734750B2 (ja) * 1988-02-22 1995-04-19 三菱化学株式会社 エリスリトールの分離・回収方法
DE3831771A1 (de) * 1988-09-19 1990-03-29 Heraeus Sepatech Verfahren zum abtrennen von hochmolekularen substanzen aus fluessigen naehrmedien sowie vorrichtung zur durchfuehrung des verfahrens
JPH05232A (ja) * 1991-02-04 1993-01-08 Nitto Denko Corp 懸濁物質を含む醗酵液の処理方法
US5451660A (en) * 1993-12-13 1995-09-19 Genentech, Inc. Method for purifying polypeptides
US20040248271A1 (en) 2001-06-08 2004-12-09 Bu-Soo Park Composition for detecting peptidoglycan, and diagnostic kit detecting peptidoglycan
JP4293908B2 (ja) * 2001-11-28 2009-07-08 サンド・アクチエンゲゼルシヤフト 組換えヒトエリスロポエチンのクロマトグラフィー精製
WO2003046162A2 (en) 2001-11-28 2003-06-05 Polymun Scientific Immunbiologische Forschung Gmbh Process for the production of polypeptides in mammalian cell cultures
NZ533084A (en) 2001-11-28 2006-02-24 Sandoz Ag Cell culture process
US7157276B2 (en) 2003-06-20 2007-01-02 Biogen Idec Inc. Use of depth filtration in series with continuous centrifugation to clarify mammalian cell cultures

Also Published As

Publication number Publication date
US7759117B2 (en) 2010-07-20
KR20070046818A (ko) 2007-05-03
CZ2006822A3 (cs) 2007-03-21
CN100531868C (zh) 2009-08-26
IL180173A0 (en) 2007-06-03
GEP20094715B (en) 2009-06-25
ZA200700180B (en) 2008-05-28
AU2005262431A1 (en) 2006-01-19
US20050037333A1 (en) 2005-02-17
NO20070386L (no) 2007-02-14
PL382304A1 (pl) 2007-08-06
EP1776174A1 (en) 2007-04-25
IS8582A (is) 2006-12-19
CN101014402A (zh) 2007-08-08
US20070267360A1 (en) 2007-11-22
EA200700094A1 (ru) 2007-04-27
CA2572181A1 (en) 2006-01-19
MXPA06014891A (es) 2007-03-01
EP1776174A4 (en) 2007-08-15
US7157276B2 (en) 2007-01-02
RS20060680A (sr) 2008-06-05
JP2008503218A (ja) 2008-02-07
WO2006007459A1 (en) 2006-01-19
EA011353B1 (ru) 2009-02-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.