BRPI0511088A - identificação e caracterização de um subconjunto de glioblastomas sensìveis ao tratamento com imatinib - Google Patents
identificação e caracterização de um subconjunto de glioblastomas sensìveis ao tratamento com imatinibInfo
- Publication number
- BRPI0511088A BRPI0511088A BRPI0511088-2A BRPI0511088A BRPI0511088A BR PI0511088 A BRPI0511088 A BR PI0511088A BR PI0511088 A BRPI0511088 A BR PI0511088A BR PI0511088 A BRPI0511088 A BR PI0511088A
- Authority
- BR
- Brazil
- Prior art keywords
- sensitive
- characterization
- subset
- identification
- glioblastomas
- Prior art date
Links
- 239000005517 L01XE01 - Imatinib Substances 0.000 title abstract 2
- 238000012512 characterization method Methods 0.000 title abstract 2
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002411 imatinib Drugs 0.000 title abstract 2
- 208000005017 glioblastoma Diseases 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 230000002062 proliferating effect Effects 0.000 abstract 3
- 229940124090 Platelet-derived growth factor (PDGF) receptor antagonist Drugs 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
IDENTIFICAçãO E CARACTERIZAçãO DE UM SUBCONJUNTO DE GLIOBLASTOMAS SENSìVEIS AO TRATAMENTO COM IMATINIB. A presente invenção refere-se aos métodos para diagnóstico in vitro de uma doença proliferativa celular em um mamífero, para prever o comportamento de um mamífero possuindo uma doença proliferativa celular sensível a um tratamento médico usando, pelo menos um antagonista do receptor do PDGF e para seleção de um mamífero possuindo doença proliferativa celular e previsto de ser sensível ao tratamento médico empregando pelo menos um antagonista do receptor do PDGF, por uso dos dados marcadores genéticos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0410883A GB0410883D0 (en) | 2004-05-14 | 2004-05-14 | Organic compounds |
| GB0425257A GB0425257D0 (en) | 2004-11-16 | 2004-11-16 | Organic compounds |
| PCT/EP2005/005269 WO2005113801A2 (en) | 2004-05-14 | 2005-05-13 | Identification and characterization of a subset of glioblastomas sensitive to treatment with imatinib |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0511088A true BRPI0511088A (pt) | 2007-12-26 |
Family
ID=35295424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0511088-2A BRPI0511088A (pt) | 2004-05-14 | 2005-05-13 | identificação e caracterização de um subconjunto de glioblastomas sensìveis ao tratamento com imatinib |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20080199855A1 (pt) |
| EP (1) | EP1756306A2 (pt) |
| JP (1) | JP2007536920A (pt) |
| AU (1) | AU2005245572B9 (pt) |
| BR (1) | BRPI0511088A (pt) |
| CA (1) | CA2564654A1 (pt) |
| MX (1) | MXPA06013079A (pt) |
| RU (1) | RU2006144122A (pt) |
| WO (1) | WO2005113801A2 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2679943A1 (en) * | 2007-03-02 | 2008-09-12 | Board Of Regents, The University Of Texas System | Multigene assay to predict outcome in an individual with glioblastoma |
| JP6159085B2 (ja) * | 2009-08-25 | 2017-07-05 | バーグ エルエルシー | エピメタボリックシフター（コエンザイムｑ１０）を使用する肉腫の処置方法 |
| US10260097B2 (en) * | 2011-06-02 | 2019-04-16 | Almac Diagnostics Limited | Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent |
| AU2013353839A1 (en) | 2012-12-03 | 2015-06-18 | Almac Diagnostics Limited | Molecular diagnostic test for cancer |
| GB201409479D0 (en) | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Molecular diagnostic test for cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2829154B1 (fr) * | 2001-09-05 | 2003-10-17 | Assist Publ Hopitaux De Paris | Nouveau procede de detection d'une mutation en phase de lecture dans une sequence codante et appareil pour sa mise en oeuvre |
| US20050164196A1 (en) * | 2002-04-17 | 2005-07-28 | Dressman Marlene M. | Methods to predict patient responsiveness to tyrosine kinase inhibitors |
| JP4035600B2 (ja) * | 2002-05-22 | 2008-01-23 | 国立大学法人 東京大学 | イマチニブに対する感受性の判定方法 |
-
2005
- 2005-05-13 MX MXPA06013079A patent/MXPA06013079A/es not_active Application Discontinuation
- 2005-05-13 BR BRPI0511088-2A patent/BRPI0511088A/pt not_active IP Right Cessation
- 2005-05-13 RU RU2006144122/13A patent/RU2006144122A/ru not_active Application Discontinuation
- 2005-05-13 AU AU2005245572A patent/AU2005245572B9/en not_active Expired - Fee Related
- 2005-05-13 WO PCT/EP2005/005269 patent/WO2005113801A2/en not_active Ceased
- 2005-05-13 JP JP2007512116A patent/JP2007536920A/ja active Pending
- 2005-05-13 CA CA002564654A patent/CA2564654A1/en not_active Abandoned
- 2005-05-13 US US11/568,781 patent/US20080199855A1/en not_active Abandoned
- 2005-05-13 EP EP05741985A patent/EP1756306A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2564654A1 (en) | 2005-12-01 |
| WO2005113801A2 (en) | 2005-12-01 |
| US20080199855A1 (en) | 2008-08-21 |
| MXPA06013079A (es) | 2007-10-08 |
| WO2005113801A3 (en) | 2006-02-23 |
| AU2005245572B2 (en) | 2008-12-04 |
| JP2007536920A (ja) | 2007-12-20 |
| EP1756306A2 (en) | 2007-02-28 |
| AU2005245572B9 (en) | 2009-01-29 |
| AU2005245572A1 (en) | 2005-12-01 |
| RU2006144122A (ru) | 2008-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |