BRPI0518117A - uso de um derivado de piridotienopirimidina, composição farmacêutica, método para o tratamento de um sujeito que sofre de uma condição patológica ou doença susceptìvel de cura pela inibição da fosfodiesterase 4 e produto de combinação - Google Patents
uso de um derivado de piridotienopirimidina, composição farmacêutica, método para o tratamento de um sujeito que sofre de uma condição patológica ou doença susceptìvel de cura pela inibição da fosfodiesterase 4 e produto de combinaçãoInfo
- Publication number
- BRPI0518117A BRPI0518117A BRPI0518117-8A BRPI0518117A BRPI0518117A BR PI0518117 A BRPI0518117 A BR PI0518117A BR PI0518117 A BRPI0518117 A BR PI0518117A BR PI0518117 A BRPI0518117 A BR PI0518117A
- Authority
- BR
- Brazil
- Prior art keywords
- groups
- group
- alkyl
- phosphodiesterase
- inhibition
- Prior art date
Links
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 title abstract 3
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title abstract 3
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 230000005764 inhibitory process Effects 0.000 title abstract 3
- 230000001575 pathological effect Effects 0.000 title abstract 3
- 239000013066 combination product Substances 0.000 title abstract 2
- 229940127555 combination product Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- -1 monoalkylamino Chemical group 0.000 abstract 4
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
USO DE UM DERIVADO DE PIRIDOTIENOPIRIMIDINA, COMPOSIçãO FARMACêUTICA, MéTODO PARA O TRATAMENTO DE UM SUJEITO QUE SOFRE DE UMA CONDIçãO PATOLóGICA OU DOENçA SUSCEPTìVEL DE CURA PELA INIBIçãO DA FOSFODIESTERASE 4 E PRODUTO DE COMBINAçãO. A presente invenção refere-se ao uso de um derivado de pírído¢3', 2':4,5!tíeno¢3,2-d!pírímídína tendo a fórmula (I): onde n é um número inteiro selecionado a partir de 0 ou 1; R e R são independentemente selecionados a partir de átomos de hidrogênio e os grupos alquíla C~ 1~-C~ 4~, R representa um grupo selecionado a partir de alquíla, amíno, monoalquílamíno, díalquilamino, aríla, heteroarila, e grupos heterocíclíla contendo N saturados ligados através do átomo de nitrogênio ao anel de piridina, todos os quais sendo opcionalmente substituidos por um ou mais substituintes selecionados a partir do grupo que consiste em átomos de halogênio, e alquíla, alcóxíalquíla, arilalquíla, e grupos R¬ 6¬OCO-, alcóxi, R¬ 6¬R¬ 7¬N-CO-, -CN, -CF~ 3~, -NR¬ 6¬R¬ 7¬ , -SR¬ 6¬ e -SO~ 2~NH~ 2~ onde R~ 6~ e R~ 7~ são independentemente selecionados a partir de átomos de hidrogênio e grupos alquila C~ 1~ - C~ 4~. R¬ 4¬ e R¬ 5¬ são independentemente selecionados a partir do grupo que consiste em átomos de hidrogênio, grupos alquíla e grupos de fórmula (II) onde p e q são números inteiros selecionados a partir de 1, 2 e 3; A é ou uma ligação direta ou um grupo selecionado partir de -CONR~ 12~-, -NR~ 12~CO-, -O-, -COO-, -OCO-, -NR~ 12~COO-, -OCONR~ 12~-NR~ 12~CONR~ 1 ~ -, -S-, -SO-, -SO~ 2~-, -COS- e -SCO-; e G é um grupo selecionado a partir de arila, heteroarila ou heterociclila; onde os grupos alquíla e o grupo G são opcionalmente substituidos por um ou mais substítuíntes selecionados a partir do grupo que consiste átomos de halogênio e grupos alquíla, alcóxialquíla, arilalquila, R~ 14~OCO-, hídróxi, alcóxi, oxo, R~ 14~R~ 15~N- CO-, -CN, -CF~ 3~, -NR~ 14~R~ 15~, -SR~ 14~ e -SO~ 2~NH~ 2~; onde os grupos de R~ 8~ a R~ 15~ são independentemente selecionados a partir de átomos de hidrogênio e grupos alquila C~ 1~-C~ 4~, e os sais farmaceutícamente aceitáveis e N-óxidos dos mesmos; e os sais farmaceuticamente aceitáveis e N-óxídos dos mesmos; na fabricação de um medicamento para o tratamento ou a prevenção de uma condição patológica ou doença susceptível de cura pela inibição da fosfodiesterase 4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200402877A ES2259892B1 (es) | 2004-11-30 | 2004-11-30 | Nuevos derivados de piridotienopirimidina. |
| PCT/EP2005/012773 WO2006058723A1 (en) | 2004-11-30 | 2005-11-30 | New pyridothienopyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0518117A true BRPI0518117A (pt) | 2008-11-04 |
Family
ID=35064809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0518117-8A BRPI0518117A (pt) | 2004-11-30 | 2005-11-30 | uso de um derivado de piridotienopirimidina, composição farmacêutica, método para o tratamento de um sujeito que sofre de uma condição patológica ou doença susceptìvel de cura pela inibição da fosfodiesterase 4 e produto de combinação |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20080207645A1 (pt) |
| EP (1) | EP1819712A1 (pt) |
| JP (1) | JP2008521854A (pt) |
| KR (1) | KR20070086652A (pt) |
| CN (1) | CN101068817A (pt) |
| AR (1) | AR052413A1 (pt) |
| AU (1) | AU2005311422A1 (pt) |
| BR (1) | BRPI0518117A (pt) |
| CA (1) | CA2588808A1 (pt) |
| ES (1) | ES2259892B1 (pt) |
| IL (1) | IL183141A0 (pt) |
| MX (1) | MX2007006172A (pt) |
| NO (1) | NO20073271L (pt) |
| PE (1) | PE20061080A1 (pt) |
| RU (1) | RU2007124493A (pt) |
| TW (1) | TW200631954A (pt) |
| UY (1) | UY29240A1 (pt) |
| WO (1) | WO2006058723A1 (pt) |
| ZA (1) | ZA200703700B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2281251B1 (es) * | 2005-07-27 | 2008-08-16 | Laboratorios Almirall S.A. | Nuevos derivados de pirido (3',2':4,5) furo (3,2-d) pirimidina. |
| WO2012131297A1 (en) | 2011-03-28 | 2012-10-04 | Jonathan Bayldon Baell | Pyrido [3',2' :4,5] thieno [3, 2-d] pyrimidin- 4 - ylamine derivatives and their therapeutical use |
| KR20140127218A (ko) | 2011-12-21 | 2014-11-03 | 인비스타 테크놀러지스 에스.에이 알.엘. | 안정한 에멀젼을 감소시키기 위한 추출 용매 제어 |
| CN103242276B (zh) * | 2013-05-07 | 2014-07-16 | 白银安杰利生化科技有限公司 | 2,2-二甲基四氢-2h-吡喃-4-羧酸的合成方法 |
| GEP20207167B (en) | 2016-06-22 | 2020-10-12 | Univ Vanderbilt | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| CN109863139B (zh) | 2016-11-07 | 2023-02-17 | 范德比尔特大学 | 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂 |
| CN109862893B (zh) | 2016-11-07 | 2023-02-17 | 范德比尔特大学 | 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂 |
| US11008335B2 (en) | 2016-11-07 | 2021-05-18 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| TW201930311A (zh) | 2017-12-05 | 2019-08-01 | 泛德比爾特大學 | 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑 |
| MA51036A (fr) | 2017-12-05 | 2021-03-17 | Univ Vanderbilt | Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19644228A1 (de) * | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
| DE19752952A1 (de) * | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidine |
| DE19819023A1 (de) * | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidine |
| KR20010105399A (ko) * | 1999-03-30 | 2001-11-28 | 쓰끼하시 다미까따 | 티에노피리미딘 화합물 및 그의 염, 및 그들의 제조 방법 |
-
2004
- 2004-11-30 ES ES200402877A patent/ES2259892B1/es not_active Expired - Fee Related
-
2005
- 2005-11-28 AR ARP050104957A patent/AR052413A1/es unknown
- 2005-11-28 PE PE2005001378A patent/PE20061080A1/es not_active Application Discontinuation
- 2005-11-29 UY UY29240A patent/UY29240A1/es unknown
- 2005-11-30 AU AU2005311422A patent/AU2005311422A1/en not_active Abandoned
- 2005-11-30 EP EP05813317A patent/EP1819712A1/en not_active Withdrawn
- 2005-11-30 CN CNA2005800409703A patent/CN101068817A/zh active Pending
- 2005-11-30 KR KR1020077014496A patent/KR20070086652A/ko not_active Withdrawn
- 2005-11-30 TW TW094142174A patent/TW200631954A/zh unknown
- 2005-11-30 BR BRPI0518117-8A patent/BRPI0518117A/pt not_active IP Right Cessation
- 2005-11-30 US US11/791,451 patent/US20080207645A1/en not_active Abandoned
- 2005-11-30 JP JP2007543766A patent/JP2008521854A/ja active Pending
- 2005-11-30 CA CA002588808A patent/CA2588808A1/en not_active Abandoned
- 2005-11-30 MX MX2007006172A patent/MX2007006172A/es not_active Application Discontinuation
- 2005-11-30 RU RU2007124493/04A patent/RU2007124493A/ru not_active Application Discontinuation
- 2005-11-30 WO PCT/EP2005/012773 patent/WO2006058723A1/en not_active Ceased
-
2007
- 2007-05-08 ZA ZA200703700A patent/ZA200703700B/en unknown
- 2007-05-10 IL IL183141A patent/IL183141A0/en unknown
- 2007-06-26 NO NO20073271A patent/NO20073271L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008521854A (ja) | 2008-06-26 |
| UY29240A1 (es) | 2006-02-24 |
| PE20061080A1 (es) | 2006-11-10 |
| TW200631954A (en) | 2006-09-16 |
| IL183141A0 (en) | 2007-09-20 |
| NO20073271L (no) | 2007-06-26 |
| KR20070086652A (ko) | 2007-08-27 |
| MX2007006172A (es) | 2007-07-13 |
| AU2005311422A1 (en) | 2006-06-08 |
| WO2006058723A8 (en) | 2007-07-12 |
| CN101068817A (zh) | 2007-11-07 |
| EP1819712A1 (en) | 2007-08-22 |
| ES2259892A1 (es) | 2006-10-16 |
| AR052413A1 (es) | 2007-03-21 |
| US20080207645A1 (en) | 2008-08-28 |
| RU2007124493A (ru) | 2009-01-10 |
| ZA200703700B (en) | 2008-07-30 |
| CA2588808A1 (en) | 2006-06-08 |
| ES2259892B1 (es) | 2007-11-01 |
| WO2006058723A1 (en) | 2006-06-08 |
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