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BRPI0503201A - stents revestidos com blendas poliméricas hidrofìlicas, eluidoras de óxido nìtrico e s-nitrosotióis - Google Patents

stents revestidos com blendas poliméricas hidrofìlicas, eluidoras de óxido nìtrico e s-nitrosotióis

Info

Publication number
BRPI0503201A
BRPI0503201A BRPI0503201-6A BRPI0503201A BRPI0503201A BR PI0503201 A BRPI0503201 A BR PI0503201A BR PI0503201 A BRPI0503201 A BR PI0503201A BR PI0503201 A BRPI0503201 A BR PI0503201A
Authority
BR
Brazil
Prior art keywords
poly
nitrosothiols
nitric oxide
vinyl alcohol
vinyl pyrrolidone
Prior art date
Application number
BRPI0503201-6A
Other languages
English (en)
Inventor
Marcelo Ganzarolli De Oliveira
Alexander Marra Moreira
Amedea Barozzi Seabra
Maira Martins De Souza Simoes
Spero Penha Morato
Original Assignee
Unicamp
Sci Tech Produtos Medicos Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unicamp, Sci Tech Produtos Medicos Ltda filed Critical Unicamp
Priority to BRPI0503201A priority Critical patent/BRPI0503201B8/pt
Priority to PCT/BR2006/000073 priority patent/WO2007012165A1/en
Priority to US11/997,087 priority patent/US20100112033A1/en
Publication of BRPI0503201A publication Critical patent/BRPI0503201A/pt
Publication of BRPI0503201B1 publication Critical patent/BRPI0503201B1/pt
Publication of BRPI0503201B8 publication Critical patent/BRPI0503201B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/114—Nitric oxide, i.e. NO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)

Abstract

"STENTS REVESTIDOS COM BLENDAS POLIMéRICAS HIDROFìLICAS, ELUIDORAS DE óXIDO NìTRICO E S-NITROSOTIóIS". A presente invenção se refere a um dispositivo para implante intracoronário, introduzindo novos stents eluidores de S-Nitrosotióis revestidos com multicamadas de polímeros hidrofílicos, utilizado em procedimentos médicos e se refere aos processos de revestimento de stents com polímeros hidrofílicos contendo S-nitrosotióis incorporados. Os stents revestidos com polímeros hidrofílicos contendo S-nitrosotióis são capazes de liberar localmente tanto o óxido nítrico como os próprios S-nitrosotióis, por difusão para aplicações em angioplastia coronária, com o objetivo de inibir a reestenose aguda e crónica. Os polímeros hidrofílicos utilizados nos revestimentos são poli (álcool vinílico), poli(vinil pirrolidona) blendas de poli(álcool vinílico)/poli(vinil pirrolidona), poli(álcool vinílico)/poli(etileno glicol), poli(vinil pirrolidona)/poli(etileno glicol) e poli(álcool vinílico)/poli(vinil pirrolidona)/poli(etileno glicol). Os processos de revestimento incluem processos de imersão dos stents nas soluções poliméricas contendo os S-nitrosotióis e processos de nebulização das soluções poliméricas contendo os S-nitrosotióis sobre a superfície dos stents.
BRPI0503201A 2005-07-28 2005-07-28 stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis BRPI0503201B8 (pt)

Priority Applications (3)

Application Number Priority Date Filing Date Title
BRPI0503201A BRPI0503201B8 (pt) 2005-07-28 2005-07-28 stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis
PCT/BR2006/000073 WO2007012165A1 (en) 2005-07-28 2006-04-19 Stents coated with no- and s-nitrosothiol-eluting hydrophilic polymeric blends
US11/997,087 US20100112033A1 (en) 2005-07-28 2006-04-19 Stents coated with no- and s-nitrosothiol-eluting hydrophlic polymeric blends

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0503201A BRPI0503201B8 (pt) 2005-07-28 2005-07-28 stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis

Publications (3)

Publication Number Publication Date
BRPI0503201A true BRPI0503201A (pt) 2007-03-13
BRPI0503201B1 BRPI0503201B1 (pt) 2020-12-22
BRPI0503201B8 BRPI0503201B8 (pt) 2021-05-25

Family

ID=37682944

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0503201A BRPI0503201B8 (pt) 2005-07-28 2005-07-28 stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis

Country Status (3)

Country Link
US (1) US20100112033A1 (pt)
BR (1) BRPI0503201B8 (pt)
WO (1) WO2007012165A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2606565C (en) 2005-05-27 2016-05-10 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
CA2599082A1 (en) * 2007-08-27 2009-02-27 Ping I. Lee Supramacromolecular polymer complexes providing controlled nitric oxide release for healing wounds
CA2671595A1 (en) * 2009-07-09 2011-01-09 Ping I. Lee Controlled nitric oxide delivery from aqueous s-nitrosothiol conjugated polymers and their complexes
BR112012003804B1 (pt) 2009-08-21 2019-02-19 Novan, Inc. Curativo para ferimentos, método para formar um curativo para ferimentos, e, kit de curativo para ferimento
CN102711729B (zh) 2009-08-21 2015-04-01 诺万公司 局部用凝胶
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
WO2012118829A2 (en) 2011-02-28 2012-09-07 Novan, Inc. Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same
EP2731661B1 (en) * 2011-07-12 2019-09-18 Boston Scientific Scimed, Inc. Drug elution medical device
US11103622B2 (en) 2013-02-07 2021-08-31 The Regents Of The University Of Michigan Thromboresistant/bactericidal s-nitroso-n-acetylpenicillamine (SNAP)-doped nitric oxide release polymers with enhanced stability
CN110446521B (zh) 2017-01-21 2022-05-06 生物克瑞德公司 配置用于一氧化氮的控制释放的医疗产品和方法
CN115089773A (zh) * 2022-07-19 2022-09-23 中国科学院长春应用化学研究所 一种血管支架仿生涂层和血管支架及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221425B1 (en) * 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
BRPI0004238B8 (pt) * 2000-09-06 2021-05-25 Univ Estadual Campinas Unicamp formulações de s-nitrosotióis doadores de óxido nítrico incorporados em matrizes de poli (etileno glicol)/etileno glicol, e metodologia para incorporação de s-nitrosotióis em matrizes de poli (etileno glicol)/etileno glicol
US6706274B2 (en) * 2001-01-18 2004-03-16 Scimed Life Systems, Inc. Differential delivery of nitric oxide
BR0201168B1 (pt) * 2002-03-26 2011-10-04 formulações de s-nitrosotióis doadores de óxido nìtrico incorporados em géis aquosos térmicamente reversìveis de copolìmero tribloco de poli(óxido de etileno) - poli(óxido de propileno) - poli(óxido de etileno) e metodologia de incorporação de s-nitrosotióis em matrizes de géis aquosos de copolìmero tribloco de poli(óxido de etileno) - poli(óxido de propileno) - poli(óxido de etileno).
BR0201167A (pt) * 2002-03-26 2003-11-18 Unicamp Filmes poliméricos sólidos de poli(álcool vinìlico) e poli(álcool vinìlico) - poli (vinil pirrolidona), contendo s-nitrosotióis doadores de óxido nìtrico, bem como os métodos para sua preparação
WO2005018697A2 (en) * 2003-08-13 2005-03-03 Medtronic, Inc. Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices, and methods
US7229471B2 (en) * 2004-09-10 2007-06-12 Advanced Cardiovascular Systems, Inc. Compositions containing fast-leaching plasticizers for improved performance of medical devices

Also Published As

Publication number Publication date
BRPI0503201B1 (pt) 2020-12-22
WO2007012165A1 (en) 2007-02-01
BRPI0503201B8 (pt) 2021-05-25
US20100112033A1 (en) 2010-05-06

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Legal Events

Date Code Title Description
B15K Others concerning applications: alteration of classification

Ipc: A61L 27/54 (2010.01), A61F 2/82 (2010.01)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: A61L 27/54 (2006.01), A61F 2/82 (2013.01)

B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/12/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/07/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF