[go: up one dir, main page]

BRPI0509668A - compound, pharmaceutical composition comprising the same, method of treating the disease, inflammatory disorder or symptom and method of preparing the compound - Google Patents

compound, pharmaceutical composition comprising the same, method of treating the disease, inflammatory disorder or symptom and method of preparing the compound

Info

Publication number
BRPI0509668A
BRPI0509668A BRPI0509668-5A BRPI0509668A BRPI0509668A BR PI0509668 A BRPI0509668 A BR PI0509668A BR PI0509668 A BRPI0509668 A BR PI0509668A BR PI0509668 A BRPI0509668 A BR PI0509668A
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
symptom
same
disease
Prior art date
Application number
BRPI0509668-5A
Other languages
Portuguese (pt)
Inventor
Shomir Ghosh
Amy M Elder
Kevin T Sprott
Frederick A Hicks
Dominic Reynolds
Kenneth G Carson
Sean J Harrison
Christelle C Renou
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of BRPI0509668A publication Critical patent/BRPI0509668A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

COMPOSTO, COMPOSIçãO FARMACêUTICA QUE COMPREENDE O MESMO, MéTODO DE TRATAMENTO DE ENFERMIDADE, DISTúRBIO OU SINTOMA INFLAMATóRIO E MéTODO DE PREPARAçãO DO COMPOSTO. Expõem-se neste contexto compostos representados pelas fórmulas estruturais (I) e (I-A). Expõe-se igualmente o uso desses compostos para inibir o receptor acoplado a proteína G, chamado de molécula homóloga receptora químio-atratora expressada na Th2, ou simplesmente "CRTH2" para o tratamento de distúrbios inflamatórios. As variáveis da Fórmula Estrutural (1) e (1-A) estão definidas neste contexto.COMPOUND, PHARMACEUTICAL COMPOSITION UNDERSTANDING THE SAME, METHOD OF TREATMENT OF NURSING, INFLAMMATORY SYMPTOM, AND COMPOSITE PREPARATION METHOD. In this context, compounds represented by the structural formulas (I) and (I-A) are disclosed. The use of such compounds to inhibit the G-protein coupled receptor, called a Th2-expressed homologous receptor-receptor molecule, or simply "CRTH2" for the treatment of inflammatory disorders is also disclosed. The variables of Structural Formula (1) and (1-A) are defined in this context.

BRPI0509668-5A 2004-04-07 2005-04-07 compound, pharmaceutical composition comprising the same, method of treating the disease, inflammatory disorder or symptom and method of preparing the compound BRPI0509668A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56041004P 2004-04-07 2004-04-07
PCT/US2005/011643 WO2005100321A1 (en) 2004-04-07 2005-04-07 Pgd2 receptor antagonists for the treatment of inflammatory diseases

Publications (1)

Publication Number Publication Date
BRPI0509668A true BRPI0509668A (en) 2007-10-09

Family

ID=34965223

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509668-5A BRPI0509668A (en) 2004-04-07 2005-04-07 compound, pharmaceutical composition comprising the same, method of treating the disease, inflammatory disorder or symptom and method of preparing the compound

Country Status (21)

Country Link
EP (1) EP1740547A1 (en)
JP (1) JP2007532555A (en)
KR (1) KR20070002085A (en)
CN (1) CN101018770A (en)
AR (1) AR048528A1 (en)
AU (1) AU2005233125A1 (en)
BR (1) BRPI0509668A (en)
CA (1) CA2561564A1 (en)
CL (1) CL2008000069A1 (en)
CR (1) CR8659A (en)
EC (1) ECSP066977A (en)
IL (1) IL178328A0 (en)
MA (1) MA28566B1 (en)
MX (1) MXPA06011540A (en)
NO (1) NO20065107L (en)
RU (1) RU2006138603A (en)
TN (1) TNSN06320A1 (en)
TW (1) TW200538127A (en)
UA (1) UA84749C2 (en)
WO (1) WO2005100321A1 (en)
ZA (1) ZA200608955B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008543726A (en) 2005-02-24 2008-12-04 ミレニアム・ファーマシューティカルズ・インコーポレイテッド PGD2 receptor antagonist for the treatment of inflammatory diseases
EP1717235A3 (en) * 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
KR101020351B1 (en) 2005-07-29 2011-03-08 에프. 호프만-라 로슈 아게 Indol-3-yl-carbonyl-piperidine and piperazine derivatives
WO2007149312A2 (en) 2006-06-16 2007-12-27 The Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and bph
MX2009002019A (en) 2006-08-24 2009-03-09 Novartis Ag 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyraz0l-3-yl) -thiazole derivatives as well as related compounds as stearoyl-coa desaturase (scd) inhibitors for the treatment of metabolic, cardiovascular and other disorders.
JPWO2008029924A1 (en) 2006-09-08 2010-01-21 大日本住友製薬株式会社 Cyclic aminoalkylcarboxamide derivatives
CA2662574A1 (en) 2006-09-22 2008-03-27 Novartis Ag Heterocyclic organic compounds
MX2009006728A (en) 2006-12-20 2009-09-09 Novartis Ag 2-substituted 5-membered heterocycles as scd inhibitors.
US20100222347A1 (en) 2007-09-27 2010-09-02 Kowa Company, Ltd. Prophylactic and/or therapeutic agent for anemia, comprising tetrahydroquinoline compound as active ingredient
ATE502920T1 (en) 2007-12-14 2011-04-15 Pulmagen Therapeutics Asthma Ltd INDOLES AND THEIR THERAPEUTIC USE
JP2011102241A (en) * 2008-03-04 2011-05-26 Dainippon Sumitomo Pharma Co Ltd Novel 1-aminocarbonylpiperidine derivative
DK2328619T3 (en) 2008-08-22 2017-03-13 Baxalta GmbH POLYMER BENZYL CARBONATE DERIVATES
JP2011256110A (en) * 2008-09-30 2011-12-22 Takeda Chem Ind Ltd Manufacturing method of hexahydropyrroloquinoline
WO2010113498A1 (en) 2009-03-31 2010-10-07 興和株式会社 Prophylactic and/or therapeutic agent for anemia comprising tetrahydroquinoline compound as active ingredient
GB0919431D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
WO2011054851A1 (en) 2009-11-05 2011-05-12 Glaxosmithkline Llc Novel process
EP2590944B1 (en) 2010-07-05 2015-09-30 Actelion Pharmaceuticals Ltd. 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
PE20140788A1 (en) 2011-06-17 2014-07-09 Merck Sharp & Dohme CYCLOALKYL CONDENSED TETRAHYDROQUINOLINES AS CRTH2 RECEPTOR MODULATORS
JP2015500326A (en) 2011-12-16 2015-01-05 アトピックス テラピューティクス リミテッド Combination of CRTH2 antagonist and proton pump inhibitor for the treatment of eosinophilic esophagitis
EP2794563B1 (en) 2011-12-21 2017-02-22 Actelion Pharmaceuticals Ltd Heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
WO2014006585A1 (en) 2012-07-05 2014-01-09 Actelion Pharmaceuticals Ltd 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
US20180021302A1 (en) 2015-02-13 2018-01-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus
HK1256553A1 (en) 2015-07-30 2019-09-27 The Trustees Of The University Of Pennsylvania Single nucleotide polymorphic alleles of human dp-2 gene for detection of susceptibility to hair growth inhibition by pgd2
JOP20190105A1 (en) * 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc Magl inhibitors
HUE066783T2 (en) 2018-04-18 2024-09-28 Constellation Pharmaceuticals Inc Modulators of methyl modifying enzymes, their preparations and their application
CA3100977A1 (en) 2018-05-21 2019-11-28 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
CN113201316B (en) * 2021-04-25 2022-08-26 西南石油大学 temperature/CO 2 pH multi-responsive emulsifier and emulsion and application thereof
CN116425623B (en) * 2023-04-10 2024-02-13 大连凯飞化学股份有限公司 Method for synthesizing 3,5-dichloro-4-methylbenzoic acid by one-pot method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100596284B1 (en) * 1998-03-31 2006-07-03 시오노기 앤드 컴파니, 리미티드 Method for preparing 5-hydroxybenzo [bi] thiophene-3-carboxylic acid derivative
CA2445693A1 (en) * 2001-04-30 2002-11-07 Pfizer Products Inc. Compounds useful as intermediates for 4-aminoquinoline derivatives
JP2003321471A (en) * 2002-04-30 2003-11-11 Fuji Photo Film Co Ltd Lactam compound and method of production for the same
US20040053842A1 (en) * 2002-07-02 2004-03-18 Pfizer Inc. Methods of treatment with CETP inhibitors and antihypertensive agents
KR20050055747A (en) * 2002-10-04 2005-06-13 밀레니엄 파머슈티컬스 인코퍼레이티드 Pgd2 receptor antagonists for the treatment of inflammatory diseases
ES2263015T3 (en) * 2002-10-21 2006-12-01 Warner-Lambert Company Llc TETRAHYDROQUINOLINE DERIVATIVES AS AN ANTHOGONIST OF CRTH2
AU2003289207A1 (en) * 2002-12-06 2004-06-30 Kyowa Hakko Kogyo Co., Ltd. Anti-inflammatory agent
EP1435356A1 (en) * 2003-01-06 2004-07-07 Warner-Lambert Company LLC Quinoline derivatives as CRTH2 antagonists

Also Published As

Publication number Publication date
UA84749C2 (en) 2008-11-25
KR20070002085A (en) 2007-01-04
TW200538127A (en) 2005-12-01
WO2005100321A1 (en) 2005-10-27
ECSP066977A (en) 2006-12-29
NO20065107L (en) 2006-12-01
TNSN06320A1 (en) 2008-02-22
CL2008000069A1 (en) 2008-05-16
CA2561564A1 (en) 2005-10-27
EP1740547A1 (en) 2007-01-10
MXPA06011540A (en) 2007-01-26
IL178328A0 (en) 2007-02-11
CN101018770A (en) 2007-08-15
AR048528A1 (en) 2006-05-03
RU2006138603A (en) 2008-05-20
CR8659A (en) 2007-06-08
JP2007532555A (en) 2007-11-15
ZA200608955B (en) 2009-05-27
MA28566B1 (en) 2007-05-02
AU2005233125A1 (en) 2005-10-27

Similar Documents

Publication Publication Date Title
BRPI0509668A (en) compound, pharmaceutical composition comprising the same, method of treating the disease, inflammatory disorder or symptom and method of preparing the compound
BR0213612A (en) Compound, pharmaceutical composition, use of compound and method for treating disease or condition
BR0312216A (en) Compound, process for producing a compound, pharmaceutical composition, use of the compound, method for treating a subject suffering from a disease or condition and product combination
UY29919A1 (en) SUBSTITUTED DERIVATIVES OF 3,4-DIHYDROISOQUINOLIN-1-AMINO-TRIFLUOROACETATE, ITS PHARMACEUTICAL COMPOSITIONS AND APPLICATIONS
BRPI0515482A (en) heterocyclic derivatives and their uses as therapeutic agents
UY30407A1 (en) DERIVATIVES OF [2,3,4,8-TETRAHYDROIMIDAZO- [1,5-A] -PIRIMIDIN-8-IL] -FENIL SUBSTITUTED SULPHONATES, PHARMACEUTICAL COMPOSITIONS AND APPLICATIONS.
BRPI0409109A (en) new compounds
BR0309167A (en) Compound, process for producing a compound, pharmaceutical composition, use of the compound, method for treating a subject affected by a pathological condition or disease and combination product
BRPI0417323A (en) indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, compound, pharmaceutical composition and uses thereof
BRPI0517945A (en) quinuclidine derivatives and their use as m3 muscarinic receptor antagonists
BR0312398A (en) Substituted 1,3-diphenylprop-2-en-1-one derivative, compound preparation process, pharmaceutical composition and use of at least one substituted 1,3-diphenylprop-2-en-1-one derivative
MA31158B1 (en) Tricyclic compounds and their use as modifiers for glucocorticoid receptors.
MA31593B1 (en) 2-AZA-BICYCLO [3.3.0] OCTANE DERIVATIVES
SI1716152T1 (en) Condensed heterocyclic compounds and their use as metabotropic receptor antagonists for the treatment of gastrointestinal disorders
MA29170B1 (en) PURINIC DERIVATIVES AS A2A RECEPTOR AGONISTS
AR024240A1 (en) COMPOUNDS OF 4- (AMINOMETIL) -PIPERIDIN BENZAMIDA USEFUL TO TREAT GASTROINTESTINAL DISORDERS, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM, PROCESS TO PREPARE SUCH PHARMACEUTICAL COMPOSITION, INTERMEDIATE COMPOSITE TO PREPARE PREPARATION FOR PREPARATION
BRPI0407253A (en) Heterocyclyl-3-sulfonylindazoles as ligands 5-hydroxytryptamine-6 process for their preparation, their uses in the preparation of a pharmaceutical composition and a pharmaceutical composition comprising said compounds
MA30821B1 (en) PYRAZOLINE DERIVATIVES USEFUL AS ANTAGONISTS OF MINERALOCORTICOID RECEPTORS
TN2009000483A1 (en) 7-ALKYNYL-1-8-NAPHTHYRIDONES DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF
CL2008003811A1 (en) 4-aminopyrimidine-2,6-disubstituted derivative compounds, histamine h4 receptor antagonists; Preparation process; pharmaceutical composition comprising said compound; and use of the compound for the treatment of an allergic, immunological or inflammatory disease, or pain.
ATE459619T1 (en) GLUCAGON RECEPTOR ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC USE
ATE479433T1 (en) NEW LONG-ACTING BETA-2 AGONISTS AND THEIR USE AS MEDICINAL PRODUCTS
BRPI0516454A (en) compound, process for preparing a compound, pharmaceutical composition comprising it, its use, method for treating and prophylaxis of diseases, and type II diabetes
BRPI0606437A (en) compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, use of a compound, and method of treating a platelet aggregation disorder
BRPI0507657A (en) compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, method for treating a disorder, and use of a compound or a pharmaceutically acceptable salt thereof

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.