BRPI0507777A - método para produzir um composto de 4-nitroimidazol - Google Patents
método para produzir um composto de 4-nitroimidazolInfo
- Publication number
- BRPI0507777A BRPI0507777A BRPI0507777-0A BRPI0507777A BRPI0507777A BR PI0507777 A BRPI0507777 A BR PI0507777A BR PI0507777 A BRPI0507777 A BR PI0507777A BR PI0507777 A BRPI0507777 A BR PI0507777A
- Authority
- BR
- Brazil
- Prior art keywords
- nitroimidazole compound
- produce
- nitroimidazole
- producing
- general formula
- Prior art date
Links
- -1 4-nitroimidazole compound Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 238000004880 explosion Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dentistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Medicinal Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Abstract
MéTODO PARA PRODUZIR UM COMPOSTO DE 4-NITROIMIDAZOL A presente invenção proporciona um método para produzir um composto de 4-nitroimidazol representado pela fórmula geral (1) com alto rendimento e com alta pureza, por meio de um método seguro que causa poucos perigos, como explosão. O método de produção da presente invenção compreende iodar um composto de 4-nitrosoimidazol representado pela fórmula geral (2): sendo que cada um de X¬1¬ e X¬2¬ representa um átomo de cloro ou átomo de bromo, e, depois reduzir o composto de 5-iodo-4-nitroimidazol obtido representado pela fórmula geral (3): sendo que X¬2¬ é como definido acima.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004041381 | 2004-02-18 | ||
| JP2004278999 | 2004-09-27 | ||
| PCT/JP2005/002668 WO2005077913A1 (en) | 2004-02-18 | 2005-02-15 | Method for producing 4-nitroimidazole compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0507777A true BRPI0507777A (pt) | 2007-07-17 |
Family
ID=34863488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0507777-0A BRPI0507777A (pt) | 2004-02-18 | 2005-02-15 | método para produzir um composto de 4-nitroimidazol |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7569702B2 (pt) |
| EP (1) | EP1720838B1 (pt) |
| JP (1) | JP4789483B2 (pt) |
| KR (1) | KR100830386B1 (pt) |
| CN (1) | CN100526300C (pt) |
| AR (1) | AR047672A1 (pt) |
| AT (1) | ATE366241T1 (pt) |
| AU (1) | AU2005212093B2 (pt) |
| BR (1) | BRPI0507777A (pt) |
| CA (1) | CA2555372A1 (pt) |
| DE (1) | DE602005001553T2 (pt) |
| EG (1) | EG24393A (pt) |
| ES (1) | ES2289695T3 (pt) |
| MY (1) | MY141776A (pt) |
| RU (1) | RU2345071C2 (pt) |
| TW (1) | TWI300409B (pt) |
| UA (1) | UA82773C2 (pt) |
| WO (1) | WO2005077913A1 (pt) |
| ZA (1) | ZA200606332B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI331607B (en) * | 2002-10-15 | 2010-10-11 | Otsuka Pharma Co Ltd | 1-substituted-4-nitroimidazole compound |
| TW200624422A (en) * | 2004-09-27 | 2006-07-16 | Otsuka Pharma Co Ltd | Process for production of 2-chloro-4-nitroimidazole |
| JP5072675B2 (ja) * | 2007-04-03 | 2012-11-14 | 四国化成工業株式会社 | ２−ハロイミダゾール化合物の製造方法 |
| WO2010021409A1 (en) | 2008-08-21 | 2010-02-25 | Dynamit Nobel Gmbh Explosivstoff - Und Systemtechnik | Methods for the production of 2-halo-4-nitroimidazole and intermediates thereof |
| RU2542988C2 (ru) * | 2009-07-31 | 2015-02-27 | Глоубал Элаенс Фор Тб Драг Дивелопмент | Нитроимидазооксазины и их применения при противотуберкулезной терапии |
| CN103265494A (zh) * | 2013-05-28 | 2013-08-28 | 南京理工大学 | 一种硝基咪唑含能化合物及其制备方法 |
| CN105439957B (zh) * | 2015-11-24 | 2018-05-08 | 浙江省诸暨合力化学对外贸易有限公司 | 一种合成2-溴-4-硝基咪唑的方法 |
| KR20200116118A (ko) | 2018-01-29 | 2020-10-08 | 오츠카 세이야쿠 가부시키가이샤 | 2-클로로-4-니트로이미다졸 유도체의 제조 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3341548A (en) * | 1964-04-29 | 1967-09-12 | Hoffmann La Roche | Nitroimidazoles and their preparation |
| DE2414280C2 (de) * | 1974-03-25 | 1981-12-17 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von 1-Methyl-5-nitroimidazolen |
| IL88943A (en) * | 1988-01-15 | 1994-05-30 | Rhone Poulenc Sante | Process for preparing 1-alkyl-5- nitroimidazoles |
| RU2049780C1 (ru) * | 1992-12-04 | 1995-12-10 | Государственный научно-исследовательский институт "Кристалл" | Способ получения производных 2-r-4(5)-нитроимидазолов |
| US5668127A (en) | 1995-06-26 | 1997-09-16 | Pathogenesis Corporation | Nitroimidazole antibacterial compounds and methods of use thereof |
| TWI347946B (en) | 2002-10-11 | 2011-09-01 | Otsuka Pharma Co Ltd | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound |
| TWI331607B (en) * | 2002-10-15 | 2010-10-11 | Otsuka Pharma Co Ltd | 1-substituted-4-nitroimidazole compound |
-
2005
- 2005-02-01 TW TW094103101A patent/TWI300409B/zh not_active IP Right Cessation
- 2005-02-08 MY MYPI20050484A patent/MY141776A/en unknown
- 2005-02-15 ZA ZA200606332A patent/ZA200606332B/en unknown
- 2005-02-15 AU AU2005212093A patent/AU2005212093B2/en not_active Ceased
- 2005-02-15 RU RU2006133312/04A patent/RU2345071C2/ru not_active IP Right Cessation
- 2005-02-15 UA UAA200610008A patent/UA82773C2/uk unknown
- 2005-02-15 KR KR1020067017553A patent/KR100830386B1/ko not_active Expired - Fee Related
- 2005-02-15 AT AT05710450T patent/ATE366241T1/de not_active IP Right Cessation
- 2005-02-15 CA CA002555372A patent/CA2555372A1/en not_active Abandoned
- 2005-02-15 ES ES05710450T patent/ES2289695T3/es not_active Expired - Lifetime
- 2005-02-15 DE DE602005001553T patent/DE602005001553T2/de not_active Expired - Lifetime
- 2005-02-15 BR BRPI0507777-0A patent/BRPI0507777A/pt not_active IP Right Cessation
- 2005-02-15 EP EP05710450A patent/EP1720838B1/en not_active Expired - Lifetime
- 2005-02-15 CN CNB2005800053101A patent/CN100526300C/zh not_active Expired - Fee Related
- 2005-02-15 WO PCT/JP2005/002668 patent/WO2005077913A1/en not_active Ceased
- 2005-02-15 AR ARP050100523A patent/AR047672A1/es not_active Application Discontinuation
- 2005-02-15 US US10/589,864 patent/US7569702B2/en not_active Expired - Fee Related
- 2005-02-18 JP JP2005042010A patent/JP4789483B2/ja not_active Expired - Fee Related
-
2006
- 2006-08-14 EG EGNA2006000764 patent/EG24393A/xx active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2345071C2 (ru) | 2009-01-27 |
| EG24393A (en) | 2009-04-19 |
| DE602005001553T2 (de) | 2008-03-13 |
| ATE366241T1 (de) | 2007-07-15 |
| AU2005212093A1 (en) | 2005-08-25 |
| MY141776A (en) | 2010-06-30 |
| AR047672A1 (es) | 2006-02-01 |
| WO2005077913A1 (en) | 2005-08-25 |
| AU2005212093B2 (en) | 2008-04-03 |
| RU2006133312A (ru) | 2008-03-27 |
| ES2289695T3 (es) | 2008-02-01 |
| EP1720838A1 (en) | 2006-11-15 |
| HK1097846A1 (zh) | 2007-07-06 |
| CA2555372A1 (en) | 2005-08-25 |
| CN1922154A (zh) | 2007-02-28 |
| JP2006117628A (ja) | 2006-05-11 |
| TWI300409B (en) | 2008-09-01 |
| DE602005001553D1 (de) | 2007-08-16 |
| EP1720838B1 (en) | 2007-07-04 |
| JP4789483B2 (ja) | 2011-10-12 |
| KR20060116857A (ko) | 2006-11-15 |
| US7569702B2 (en) | 2009-08-04 |
| US20070161802A1 (en) | 2007-07-12 |
| CN100526300C (zh) | 2009-08-12 |
| TW200530194A (en) | 2005-09-16 |
| UA82773C2 (uk) | 2008-05-12 |
| KR100830386B1 (ko) | 2008-05-19 |
| ZA200606332B (en) | 2008-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112013002461A2 (pt) | método para produzir um composto, e, cristal de um composto | |
| BR112014004313A8 (pt) | Composto glicosídeo, métodos de produção de um tioéter, de éter e de composto glicosídeo, e, éter. | |
| BR112014004268A8 (pt) | método para a produção de agente de controle de praga | |
| BR112012033013A2 (pt) | composição de controle de doenças de plantas e método de controle de doenças de plantas | |
| MX2010000770A (es) | Seleccionar trayectoria optima de pozo de sondeo mientras se perfora. | |
| PE20120617A1 (es) | Procesos para preparar cobicistat y sus productos intermedios | |
| MX2009008781A (es) | Derivados de ciclohexano espirociclicos. | |
| WO2009154754A3 (en) | Synthesis of deuterated morpholine derivatives | |
| CY1111327T1 (el) | Υποκατεστημενα παραγωγα κυκλοεξυλοξεικου οξεος | |
| BRPI0507777A (pt) | método para produzir um composto de 4-nitroimidazol | |
| BR112015015097A2 (pt) | método para produção de composto de amina purificada | |
| BR112012022823A2 (pt) | composto contendo anel de piridina e método para produzir derivado de picolina halogenada e derivado de tetrazoliloxima | |
| WO2009066735A1 (ja) | ２－アザアダマンタン類の製造方法 | |
| TW201129550A (en) | Method for producing diepoxy compound | |
| TW200633989A (en) | Method for producing (4,5-dihydroisoxazolo-3-yl)thioformamidine chloride | |
| BR112013003992A2 (pt) | método de produção | |
| BRPI0509095A (pt) | método para produzir um composto aminofenol | |
| TW200610750A (en) | Process for preparing 1,3-dibromoacetone, 1,3-dichloroacetone and epichlorohydrin | |
| BRPI0518958A2 (pt) | mÉtodo para produzir l-biopterina | |
| ATE438617T1 (de) | Substituierte cyclohexyl-1,4-diamin-derivate | |
| BR112014007460A2 (pt) | processos enanciosseletivos para pirrolidinas 3-aril-3-trifluorometil-substituídas inseticidas | |
| BRPI0606976A2 (pt) | processo para preparação de intermediários | |
| NO20051911D0 (no) | Synthesis | |
| BRPI0411717A (pt) | processo para a preparação de acilsulfamoibenzamidas | |
| ATE498617T1 (de) | Verfahren zur herstellung einer 3-o- alkylascorbinsäure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014. |