[go: up one dir, main page]

BRPI0506795A - microorganismo, vetor e processo para preparação de l-aminoácidos a partir de d-aminoácidos - Google Patents

microorganismo, vetor e processo para preparação de l-aminoácidos a partir de d-aminoácidos

Info

Publication number
BRPI0506795A
BRPI0506795A BRPI0506795-2A BRPI0506795A BRPI0506795A BR PI0506795 A BRPI0506795 A BR PI0506795A BR PI0506795 A BRPI0506795 A BR PI0506795A BR PI0506795 A BRPI0506795 A BR PI0506795A
Authority
BR
Brazil
Prior art keywords
amino acids
preparing
microorganism
vector
amino acid
Prior art date
Application number
BRPI0506795-2A
Other languages
English (en)
Inventor
Werner Hummel
Birgit Geueke
Steffen Osswald
Christoph Weckbecker
Klaus Huthmacher
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of BRPI0506795A publication Critical patent/BRPI0506795A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

MICROORGANISMO, VETOR E PROCESSO PARA PREPARAçãO DE L-AMINOáCIDOS A PARTIR DE D-AMINOáCIDOS. A presente invenção refere-se a microorganismos recombinantes, que em relação ao organismo de partida apresentam aumentada concentração ou atividade de uma oxidase de aminoácido D, de uma desidrogenase de aminoácido, de uma enzima regeneradora de co-substrato NADH e eventualmente de uma catalase e a um processo para preparação de aminoácidos L a partir de aminoácidos D com emprego destes micoorganismos.
BRPI0506795-2A 2004-02-19 2005-01-27 microorganismo, vetor e processo para preparação de l-aminoácidos a partir de d-aminoácidos BRPI0506795A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004008445A DE102004008445A1 (de) 2004-02-19 2004-02-19 Verfahren zur Herstellung von L-Aminosäuren aus D-Aminosäuren
PCT/EP2005/000768 WO2005090590A1 (de) 2004-02-19 2005-01-27 Verfahren zur herstellung von l-aminosäuren aus d-aminosäuren

Publications (1)

Publication Number Publication Date
BRPI0506795A true BRPI0506795A (pt) 2007-05-22

Family

ID=34832887

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506795-2A BRPI0506795A (pt) 2004-02-19 2005-01-27 microorganismo, vetor e processo para preparação de l-aminoácidos a partir de d-aminoácidos

Country Status (8)

Country Link
US (1) US7217544B2 (pt)
EP (1) EP1716241A1 (pt)
JP (1) JP2007522810A (pt)
CN (2) CN1922328A (pt)
BR (1) BRPI0506795A (pt)
DE (1) DE102004008445A1 (pt)
RU (1) RU2006133266A (pt)
WO (1) WO2005090590A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090209012A1 (en) * 2005-06-09 2009-08-20 Daicel Chemical Industries, Ltd. Method for producing l-amino acids
EP1918375B1 (en) * 2005-08-02 2015-03-11 Kaneka Corporation D-amino acid oxidase, and method for production of l-amino acid, 2-oxo acid or cyclic imine
JP5407858B2 (ja) * 2006-07-19 2014-02-05 味の素株式会社 腸内細菌科の細菌を用いたｌ−アミノ酸の製造方法
JP5005293B2 (ja) * 2006-08-22 2012-08-22 株式会社カネカ Ｄ−アミノ酸オキシダーゼ、およびｌ−アミノ酸、２−オキソ酸、又は環状イミンの製造方法。
JPWO2008047656A1 (ja) * 2006-10-12 2010-02-25 株式会社カネカ Ｌ−アミノ酸の製造方法
US8133717B2 (en) 2006-12-22 2012-03-13 Richmond Chemical Corporation Stereoinversion of amino acids in a single reactor
JPWO2010067578A1 (ja) * 2008-12-09 2012-05-17 株式会社カネカ 新規なアミノ酸脱水素酵素、およびｌ−アミノ酸、２−オキソ酸、又はｄ−アミノ酸の製造方法
CN102174632A (zh) * 2009-05-19 2011-09-07 重庆邮电大学 一种非天然l-氨基酸的生物催化去消旋化制备方法
US9080192B2 (en) 2010-02-10 2015-07-14 Codexis, Inc. Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
CN104557911B (zh) * 2013-10-17 2016-08-31 苏州同力生物医药有限公司 一种左旋吡喹酮的制备方法
JP2017514464A (ja) * 2014-04-30 2017-06-08 エボニック デグサ ゲーエムベーハーＥｖｏｎｉｋ Ｄｅｇｕｓｓａ ＧｍｂＨ 好アルカリ菌を使用するｌ−アミノ酸の製造方法
WO2016006521A1 (ja) 2014-07-11 2016-01-14 住友化学株式会社 酸化酵素、それをコードするポリヌクレオチド、及びそれらの利用
EP4636081A2 (en) 2016-03-02 2025-10-22 Basf Se Methods for making l-glufosinate
CN106520651A (zh) * 2016-11-08 2017-03-22 江南大学 一种利用酶法转化生产l‑正缬氨酸的方法
CN107502647B (zh) * 2017-09-15 2020-12-15 浙江大学 一种生物酶法去消旋化制备l-草铵膦的方法
CN109971802B (zh) * 2017-12-28 2023-04-07 苏州同力生物医药有限公司 一种酶法拆分制备(s)-1,2,3,4-四氢异喹啉-1-甲酸及其衍生物的方法
CN113969269B (zh) 2021-04-29 2024-05-03 永农生物科学有限公司 D-氨基酸氧化酶突变体及其在制备l-草铵膦中的应用
EP4105335A1 (en) 2021-06-16 2022-12-21 Evonik Operations GmbH Enzymatic method for the production of l-glufosinate p-alkyl esters
US12398410B2 (en) 2022-03-14 2025-08-26 Evonik Operations Gmbh Enzymatic method for the production of L-glufosinate P-esters
CN118222528B (zh) * 2024-04-25 2025-09-16 昆明理工大学 一种谷氨酸脱氢酶基因RkGDH2及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19606494A1 (de) 1996-02-22 1997-08-28 Degussa Enzym mit LeuDH-Aktivität, dafür codierende Nukleotid-Sequenz und Verfahren zur Herstellung des Enzyms
ES2109194B1 (es) * 1996-04-22 1998-07-16 Antibioticos Sa Un procedimiento para producir la enzima d-aminoacido oxidasa de rhodotorula gracilis en celulas hospedantes.
EP1654371A4 (en) * 2001-06-21 2010-02-10 Verenium Corp METHOD FOR PRODUCING PURE ENANTIOMERIC PURELY COMPOUNDS AND SELECTION OF ENANTIOSELECTIVE ENZYMES
EP1375649B1 (en) * 2002-06-19 2012-03-07 Evonik Degussa GmbH D-amino acid oxidase from Arthrobacter protophormiae
DE10240603A1 (de) 2002-09-03 2004-03-11 Degussa Ag Verwendung von Malat-Dehydrogenase zur NADH-Regenerierung

Also Published As

Publication number Publication date
WO2005090590A1 (de) 2005-09-29
DE102004008445A1 (de) 2005-09-08
JP2007522810A (ja) 2007-08-16
EP1716241A1 (de) 2006-11-02
US7217544B2 (en) 2007-05-15
RU2006133266A (ru) 2008-03-27
CN1922328A (zh) 2007-02-28
CN103834607A (zh) 2014-06-04
US20060063238A1 (en) 2006-03-23

Similar Documents

Publication Publication Date Title
BRPI0506795A (pt) microorganismo, vetor e processo para preparação de l-aminoácidos a partir de d-aminoácidos
Flatley et al. Transcriptional responses of Escherichia coli to S-nitrosoglutathione under defined chemostat conditions reveal major changes in methionine biosynthesis
Chowdhury et al. Reduction of ferredoxin or oxygen by flavin‐based electron bifurcation in Megasphaera elsdenii
NZ599631A (en) Induction and stabilization of enzymatic activity in microorganisms
Takahashi et al. Bacterial d-amino acid oxidases: Recent findings and future perspectives
Gómez et al. A novel type of lysine oxidase: L-lysine-ε-oxidase
MX2007009489A (es) Microorganismos que comprenden enzimas expresadas con baja actividad de eliminacion gamma.
BR0003943A (pt) Sequências de nucleotìdeo que codificam para o gene thre e processo para a produção enzimática de l-treonina usando bactérias corineforma
Takahashi et al. A highly stable D-amino acid oxidase of the thermophilic bacterium Rubrobacter xylanophilus
Gondry et al. Cyclic dipeptide oxidase from Streptomyces noursei: Isolation, purification and partial characterization of a novel, amino acyl α, β‐dehydrogenase
Andreesen et al. Various functions of selenols and thiols in anaerobic Gram‐positive, amino acids‐utilizing bacteria
Nagata et al. Occurrence of D-amino acids in a few archaea and dehydrogenase activities in hyperthermophile Pyrobaculum islandicum
BR9809197B1 (pt) método de aumento da taxa de crescimento e/ou de controle da atividade metabólica de uma cepa bacteriana de ácido lático e composição de cultura de iniciador.
Isobe et al. Purification and characterization of an L-amino acid oxidase from Pseudomonas sp. AIU 813
CN101824443A (zh) 一种去除制备中性氨基酸的反应体系中的丙氨酸的方法
WO2010067578A1 (ja) 新規なアミノ酸脱水素酵素、およびｌ－アミノ酸、２－オキソ酸、又はｄ－アミノ酸の製造方法
Watanabe et al. Identification and characterization of trans-3-hydroxy-L-proline dehydratase and Δ1-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-L-proline metabolism of bacteria
Ruan et al. Purification and characterization of R-stereospecific amidase from Brevibacterium epidermidis ZJB-07021
EP1918375B1 (en) D-amino acid oxidase, and method for production of l-amino acid, 2-oxo acid or cyclic imine
BR0010817A (pt) Processo para a preparação fermentativa de l-aminoácidos com amplificação do gene gnd
Bae et al. Application of a thermostable glutamate racemase from Bacillus sp. SK-1 for the production of d-phenylalanine in a multi-enzyme system
Findrik et al. The influence of aeration on activity and operational stability of two snake venom amino acid oxidases
PL1706493T3 (pl) Sposób wytwarzania L-treoniny lub L-lizyny obejmujący rekombinowane enterobacteriaceae o ulepszonej aktywności enolazy
MX2011001174A (es) Metodo para modificar material de carbohidrato sin almidon utilizando enzimas de peroxidasa.
Isobe et al. Characterization of Nα-benzyloxycarbonyl-l-lysine oxidizing enzyme from Rhodococcus sp. AIU Z-35-1

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]