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BRPI0412499A - grupos protetores que portam 7-poliaminoalquil(óxi)iminometil-camptotecinas - Google Patents

grupos protetores que portam 7-poliaminoalquil(óxi)iminometil-camptotecinas

Info

Publication number
BRPI0412499A
BRPI0412499A BRPI0412499-5A BRPI0412499A BRPI0412499A BR PI0412499 A BRPI0412499 A BR PI0412499A BR PI0412499 A BRPI0412499 A BR PI0412499A BR PI0412499 A BRPI0412499 A BR PI0412499A
Authority
BR
Brazil
Prior art keywords
polyaminoalkyl
protecting groups
groups
iminomethylcamptothecin
oxide
Prior art date
Application number
BRPI0412499-5A
Other languages
English (en)
Inventor
Giuseppe Giannini
Sergio Penco
Maria Ornella Tinti
Claudio Pisano
Loredana Vesci
Lucio Merlini
Franco Zunino
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Publication of BRPI0412499A publication Critical patent/BRPI0412499A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"GRUPOS PROTETORES QUE PORTAM 7-POLIAMINOALQUIL(óXI)IMINOMETILCAMPTOTECINAS". A presente invenção refere-se a compostos que são revelados com a fórmula geral (I) em que os grupos são como definidos na descrição aqui abaixo e são caracterizados pela presença de substituintes de poliamina sobre o resíduo de imina/oxima, tais grupos amina por sua vez protegidos por grupos protetores. Os ditos compostos são dotados com atividade de inibição de topoisomerase I potente e, portanto, são úteis como medicamentos para o tratamento de tumores e infecções virais e parasíticas.
BRPI0412499-5A 2003-07-14 2004-07-06 grupos protetores que portam 7-poliaminoalquil(óxi)iminometil-camptotecinas BRPI0412499A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000344A ITRM20030344A1 (it) 2003-07-14 2003-07-14 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
PCT/IT2004/000374 WO2005005431A2 (en) 2003-07-14 2004-07-06 7-polyaminoalkyl(oxy)iminomethylcamptothecins bearing protective groups

Publications (1)

Publication Number Publication Date
BRPI0412499A true BRPI0412499A (pt) 2006-09-19

Family

ID=29765914

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412499-5A BRPI0412499A (pt) 2003-07-14 2004-07-06 grupos protetores que portam 7-poliaminoalquil(óxi)iminometil-camptotecinas

Country Status (12)

Country Link
US (1) US7612081B2 (pt)
EP (1) EP1656380A2 (pt)
JP (1) JP2007518688A (pt)
KR (1) KR20060089204A (pt)
CN (1) CN100455585C (pt)
AR (1) AR045905A1 (pt)
AU (1) AU2004255949B2 (pt)
BR (1) BRPI0412499A (pt)
CA (1) CA2532193C (pt)
IT (1) ITRM20030344A1 (pt)
TW (1) TWI335330B (pt)
WO (1) WO2005005431A2 (pt)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57185285A (en) * 1981-05-07 1982-11-15 Yakult Honsha Co Ltd Novel camptothecin derivative
JP3576171B2 (ja) 1995-06-21 2004-10-13 ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・（エス．セー．エール．アー．エス） カンプトテシンの新規な同族体、その製造方法、その医薬としての用途及びこれを含有する医薬組成物
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
US7105492B2 (en) 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
ATE216998T1 (de) 1999-03-09 2002-05-15 Sigma Tau Ind Farmaceuti Camptothecin-derivate mit antitumor-wirkung
ITRM20020305A1 (it) 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.

Also Published As

Publication number Publication date
ITRM20030344A0 (it) 2003-07-14
AR045905A1 (es) 2005-11-16
CN1918170A (zh) 2007-02-21
CA2532193C (en) 2011-11-15
CA2532193A1 (en) 2005-01-20
US7612081B2 (en) 2009-11-03
EP1656380A2 (en) 2006-05-17
WO2005005431A2 (en) 2005-01-20
ITRM20030344A1 (it) 2005-01-15
AU2004255949B2 (en) 2009-04-23
CN100455585C (zh) 2009-01-28
KR20060089204A (ko) 2006-08-08
US20070043067A1 (en) 2007-02-22
JP2007518688A (ja) 2007-07-12
TW200505930A (en) 2005-02-16
TWI335330B (en) 2011-01-01
AU2004255949A1 (en) 2005-01-20
WO2005005431A3 (en) 2005-02-24
HK1099760A1 (en) 2007-08-24

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07D 491/22; A61P 35/00

Ipc: C07D 491/22 (2011.01), A61P 35/00 (2011.01)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014.