[go: up one dir, main page]

BRPI0411652A - processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos - Google Patents

processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos

Info

Publication number
BRPI0411652A
BRPI0411652A BRPI0411652-6A BRPI0411652A BRPI0411652A BR PI0411652 A BRPI0411652 A BR PI0411652A BR PI0411652 A BRPI0411652 A BR PI0411652A BR PI0411652 A BRPI0411652 A BR PI0411652A
Authority
BR
Brazil
Prior art keywords
preparation
derivatives
peptide substituted
spirobenzoazepine
novel
Prior art date
Application number
BRPI0411652-6A
Other languages
English (en)
Inventor
Xiaohu Deng
Birdella Kenney
Jimmy T Liang
Neelakandha Mani
Frank J Villani
Fan Zhang-Plasket
Hua Zhong
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0411652A publication Critical patent/BRPI0411652A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE DERIVADOS DE ESPIROBENZOAZEPINA SUBSTITUìDOS NãO-PEPTìDICOS". A presente invenção refere-se a novos compostos de espirobenzoazepina, novos processos para a preparação de derivados de espirobenzoazepina substituídos não-peptídicos e novos processos para a preparação de intermediários na preparação de tais derivados. Novos intermediários na preparação de derivados de espirobenzoazepina substituídos não-peptídicos.
BRPI0411652-6A 2003-06-17 2004-06-16 processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos BRPI0411652A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47951503P 2003-06-17 2003-06-17
PCT/US2004/019951 WO2005000819A1 (en) 2003-06-17 2004-06-16 Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives

Publications (1)

Publication Number Publication Date
BRPI0411652A true BRPI0411652A (pt) 2006-08-08

Family

ID=33551892

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411652-6A BRPI0411652A (pt) 2003-06-17 2004-06-16 processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos

Country Status (20)

Country Link
US (2) US20040259857A1 (pt)
EP (1) EP1633721A1 (pt)
JP (1) JP2007516177A (pt)
KR (1) KR20060023164A (pt)
CN (1) CN1835926A (pt)
AR (1) AR044781A1 (pt)
AU (1) AU2004252135A1 (pt)
BR (1) BRPI0411652A (pt)
CA (1) CA2529513A1 (pt)
CL (1) CL2004001508A1 (pt)
CO (1) CO5650238A2 (pt)
CR (1) CR8167A (pt)
EA (1) EA200501829A1 (pt)
HR (1) HRP20051005A2 (pt)
IL (1) IL172629A0 (pt)
IS (1) IS8185A (pt)
NO (1) NO20060184L (pt)
RS (1) RS20050933A (pt)
TW (1) TW200510323A (pt)
WO (1) WO2005000819A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004281257C1 (en) 2003-06-17 2010-07-01 Janssen Pharmaceutica N.V. Substituted spirobenzazepines
EP1984342A2 (en) * 2006-01-20 2008-10-29 Janssen Pharmaceutica, N.V. Novel solid forms of (4r)-1-[4-(2-chloro-5-fluorobenzoyl)amino-3-methoxybenzoyl]-1,2,3,5-tetrahydro-spiro[4h-1-benzazepine-4,1'-[2]cyclopentene]-3'-carboxylic acid
AU2007299822A1 (en) 2006-09-22 2008-03-27 Janssen Pharmaceutica N.V. Spiro benzazepines as vasopressin antagonists
DK2078022T3 (da) 2006-09-22 2012-02-13 Janssen Pharmaceutica Nv Spirobenzazepiner anvendt som vasopressinantagonister
AR066834A1 (es) * 2007-06-06 2009-09-16 Janssen Pharmaceutica Nv Espirobenzoazepanos como antagonistas de vasopresina, composiciones farmaceuticas que los contienen, proceso de preparacion y usos para el tratamiento de afecciones cardiacas, renales y del sistema nervioso central.
JP2009035513A (ja) * 2007-08-02 2009-02-19 Ube Ind Ltd ４−ｎ−（メチルベンゾイル）アミノ−２−メチル安息香酸の製法
CN105609662B (zh) * 2015-12-22 2017-12-12 洪杰波 一种钙钛矿光伏材料专用的空穴传输材料的制备方法
US20230416262A1 (en) * 2020-08-07 2023-12-28 Casma Therapeutics, Inc. Trpml modulators
CN112939864B (zh) * 2021-01-29 2022-05-06 中国医科大学 螺[苯并[c]氮杂-1,1’-环己基]-3-酮类化合物
CN113735792B (zh) * 2021-09-22 2024-10-18 上海新礼泰药业有限公司 氯苯唑酸葡胺及其中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW462964B (en) * 1998-05-26 2001-11-11 Sumitomo Pharma Guanidine derivatives for the treatment and prevention of disorders caused by inhibiting hyperactivity of Na/H exchange transport system and process for producing the same
DE60113696T2 (de) * 2000-07-05 2006-07-13 Ortho-Mcneil Pharmaceutical, Inc. Nichtpeptidische substituierte spirobenzoazepine als vasopressin antagonisten
AU2004281257C1 (en) * 2003-06-17 2010-07-01 Janssen Pharmaceutica N.V. Substituted spirobenzazepines

Also Published As

Publication number Publication date
NO20060184L (no) 2006-03-13
EP1633721A1 (en) 2006-03-15
CN1835926A (zh) 2006-09-20
CO5650238A2 (es) 2006-06-30
US20040259857A1 (en) 2004-12-23
CL2004001508A1 (es) 2005-05-27
AR044781A1 (es) 2005-10-05
IL172629A0 (en) 2006-04-10
AU2004252135A1 (en) 2005-01-06
IS8185A (is) 2005-12-15
CA2529513A1 (en) 2005-01-06
TW200510323A (en) 2005-03-16
KR20060023164A (ko) 2006-03-13
EA200501829A1 (ru) 2006-06-30
HRP20051005A2 (en) 2006-09-30
WO2005000819A1 (en) 2005-01-06
US20090105220A1 (en) 2009-04-23
JP2007516177A (ja) 2007-06-21
CR8167A (es) 2008-09-10
RS20050933A (sr) 2008-04-04

Similar Documents

Publication Publication Date Title
BR0307529A (pt) Derivados de n-fenil-2-pirimidina-amina
BRPI0411268A (pt) processo para a preparação de um composto 3-aril butil-amina substituìdo
CY1106969T1 (el) Αναστολεις dpp-iv
GB0100610D0 (en) Improvements in or relating to organic compounds
BRPI0414598A (pt) indóis substituìdos
ZA200404752B (en) 6-aminomorphinane derivatives method for the production and use thereof
BR0215709A (pt) Processo para a preparação de cefdinir
BR0100982A (pt) Processo para a preparação de derivados deresorcinol
BR0301667A (pt) Processo para a preparação de polìmeros em emulsão com pureza elevada
BRPI0411652A (pt) processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos
BR0212772A (pt) Processo para a preparação de repaglinida
BR0011996A (pt) Preparação de piperidin-4-onas substituìdas
BR9807988A (pt) Processo para a preparação de um composto, e, composto.
PT1102765E (pt) Processo para a sintese de derivados de (1h)-benzo¬c|quinolizin-3-onas
BR0113259A (pt) Processo para a preparação de um composto, composto e processo para a preparação de compostos
PT1206452E (pt) Processo de preparacao de compostos benzoper-hidroisoindole
BR0209842A (pt) Processo para a preparação de imipenem
BRPI0507979A (pt) processo para preparação de um composto
BRPI0408104A (pt) processo para a produção de tibolona
PT1105392E (pt) Processo para a preparacao de intermediarios de imidazodiazepina
PT1358179E (pt) Processo de sintese e intermediarios de piridin-2-il-metilamina
BR9909151A (pt) processos para preparação de intermediários
BR0116721A (pt) Processo para a preparação de (±)-trans-4-p-fluorofenil-3-hidroximetil-1-metilpiperi dina
BR0214971A (pt) Processo para a produção de um imunossupressor
PT1250335E (pt) Processo e intermediarios para a preparacao de imidazopiridinas

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2140 DE 10/01/2012.