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BRPI0411239A - composto, processo para preparar o mesmo, composição farmacêutica, método para tratar ou prevenir um distúrbio que requer inibição de canal de potássio, e, uso de um composto - Google Patents

composto, processo para preparar o mesmo, composição farmacêutica, método para tratar ou prevenir um distúrbio que requer inibição de canal de potássio, e, uso de um composto

Info

Publication number
BRPI0411239A
BRPI0411239A BRPI0411239-3A BRPI0411239A BRPI0411239A BR PI0411239 A BRPI0411239 A BR PI0411239A BR PI0411239 A BRPI0411239 A BR PI0411239A BR PI0411239 A BRPI0411239 A BR PI0411239A
Authority
BR
Brazil
Prior art keywords
compound
treating
preventing
pharmaceutical composition
potassium channel
Prior art date
Application number
BRPI0411239-3A
Other languages
English (en)
Inventor
John Ford
Nicholas John Palmer
John Frederick Atherall
David John Madge
Brad Sherborne
Mark Bushfield
Edward Benedict Stevens
Original Assignee
Xention Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0315950.6A external-priority patent/GB0315950D0/en
Application filed by Xention Discovery Ltd filed Critical Xention Discovery Ltd
Publication of BRPI0411239A publication Critical patent/BRPI0411239A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"COMPOSTO, PROCESSO PARA PREPARAR O MESMO, COMPOSIçãO FARMACêUTICA, MéTODO PARA TRATAR OU PREVENIR UM DISTúRBIO QUE REQUER INIBIçãO DE CANAL DE POTáSSIO, E, USO DE UM COMPOSTO". A presente invenção provê compostos de tienopirimidina que são inibidores de canais de potássio. As composições farmacêuticas compreendendo os compostos e seu uso no tratamento de arritmias são também providas.
BRPI0411239-3A 2003-06-11 2004-06-10 composto, processo para preparar o mesmo, composição farmacêutica, método para tratar ou prevenir um distúrbio que requer inibição de canal de potássio, e, uso de um composto BRPI0411239A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47751803P 2003-06-11 2003-06-11
GBGB0315950.6A GB0315950D0 (en) 2003-06-11 2003-06-11 Compounds
PCT/GB2004/002454 WO2004111057A1 (en) 2003-06-11 2004-06-10 Thienopyrimidine derivatives as potassium channel inhibitors

Publications (1)

Publication Number Publication Date
BRPI0411239A true BRPI0411239A (pt) 2006-07-18

Family

ID=33554173

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411239-3A BRPI0411239A (pt) 2003-06-11 2004-06-10 composto, processo para preparar o mesmo, composição farmacêutica, método para tratar ou prevenir um distúrbio que requer inibição de canal de potássio, e, uso de um composto

Country Status (15)

Country Link
EP (1) EP1641803B3 (pt)
KR (1) KR101186678B1 (pt)
CN (1) CN1823071B (pt)
AT (1) ATE425982T1 (pt)
AU (1) AU2004247470B2 (pt)
BR (1) BRPI0411239A (pt)
CA (1) CA2528848C (pt)
DE (1) DE602004020070D1 (pt)
DK (1) DK1641803T3 (pt)
ES (1) ES2324536T7 (pt)
MX (1) MXPA05013549A (pt)
PL (1) PL1641803T6 (pt)
SI (1) SI1641803T1 (pt)
WO (1) WO2004111057A1 (pt)
ZA (1) ZA200600225B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
MXPA06015223A (es) * 2004-06-29 2007-11-09 Amgen Inc Furanopirimidinas.
ATE516291T1 (de) * 2004-10-21 2011-07-15 Dow Agrosciences Llc Thenopyrimidin-verbindungen mit fungizider aktivität
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
US7576080B2 (en) 2004-12-23 2009-08-18 Memory Pharmaceuticals Corporation Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
WO2007030582A2 (en) 2005-09-09 2007-03-15 Bristol-Myers Squibb Company Acyclic ikur inhibitors
GB0525164D0 (en) * 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
DE102007027800A1 (de) * 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung
WO2010048287A2 (en) 2008-10-22 2010-04-29 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Radioprotective agents
WO2010103130A2 (en) 2009-03-13 2010-09-16 Katholieke Universiteit Leuven, K.U.Leuven R&D Novel bicyclic heterocycles
ES2900504T3 (es) 2009-09-03 2022-03-17 Bristol Myers Squibb Co Quinazolinas como inhibidores de los canales iónicos de potasio
US8722660B2 (en) * 2010-02-17 2014-05-13 Takeda Pharmaceutical Company Limited Heterocyclic compound
GB201012889D0 (en) 2010-08-02 2010-09-15 Univ Leuven Kath Antiviral activity of novel bicyclic heterocycles
GB201015411D0 (en) 2010-09-15 2010-10-27 Univ Leuven Kath Anti-cancer activity of novel bicyclic heterocycles
WO2012044993A1 (en) * 2010-09-30 2012-04-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds, pharmaceutical compositions, and methods of treating or preventing neurodegenerative diseases or disorders
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (pt) 2011-07-01 2018-04-28
EP2780344A1 (en) * 2011-11-15 2014-09-24 Xention Limited Thieno [2, 3 - c]pyrazoles for use as potassium channel inhibitors
AR090037A1 (es) * 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
WO2013078126A1 (en) 2011-11-23 2013-05-30 Cancer Research Technology Limited Thienopyrimidine inhibitors of atypical protein kinase c
US20150045305A1 (en) 2012-01-27 2015-02-12 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014134419A1 (en) 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases
KR20150128768A (ko) * 2013-03-07 2015-11-18 글락소스미스클라인 엘엘씨 시르투인 조절제로서의 티에노[3,2-d]피리미딘-6-카르복스아미드 및 유사체
FR3015483B1 (fr) * 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN106727587A (zh) * 2016-11-28 2017-05-31 李娜 一种治疗心律失常的药物组合物
JP7514005B2 (ja) * 2017-06-21 2024-07-10 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ラソパシー、及び線維性疾患の治療のためのｒａｓスーパーファミリーと相互作用する化合物
EP3898609A1 (en) 2018-12-19 2021-10-27 Shy Therapeutics LLC Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD248593A1 (de) * 1985-01-11 1987-08-12 Univ Halle Wittenberg Verfahren zur herstellung von 4-basischsubstituierten thieno/2,3-d/pyrimidin-6-ylcarbonsaeureestern
AU781365B2 (en) * 1999-12-21 2005-05-19 Icagen, Inc. Potassium channel inhibitors
US6566380B2 (en) 2000-07-25 2003-05-20 Icagen, Inc. Potassium channel inhibitors
US6849634B2 (en) 2000-12-21 2005-02-01 Icagen Potassium channel inhibitors

Also Published As

Publication number Publication date
PL1641803T3 (pl) 2009-08-31
WO2004111057A1 (en) 2004-12-23
HK1093064A1 (en) 2007-02-23
CN1823071A (zh) 2006-08-23
CN1823071B (zh) 2012-12-19
DK1641803T3 (da) 2009-06-29
SI1641803T1 (sl) 2009-08-31
MXPA05013549A (es) 2006-04-05
ATE425982T1 (de) 2009-04-15
ZA200600225B (en) 2007-04-25
KR101186678B1 (ko) 2012-09-27
PL1641803T6 (pl) 2011-04-29
CA2528848A1 (en) 2004-12-23
KR20060057539A (ko) 2006-05-26
AU2004247470B2 (en) 2009-04-23
DE602004020070D1 (de) 2010-10-07
ES2324536T7 (es) 2012-03-16
EP1641803B3 (en) 2010-12-08
EP1641803B1 (en) 2009-03-18
EP1641803A1 (en) 2006-04-05
ES2324536T3 (es) 2009-08-10
AU2004247470A1 (en) 2004-12-23
CA2528848C (en) 2012-09-04

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Patent application procedure suspended [chapter 6.1 patent gazette]

Free format text: ELIMINAR ALGUMAS REIVINDICACOES, FALTA DE CLAREZA DAS REIVINDICACOES (ART. 25), OUTROS

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements